CDE Detailed Report
Disease: Huntington's Disease
Subdomain Name: Other Clinical Data
CRF: Neuropathology Data Form
Displaying 151 - 175 of 175
Subdomain Name: Other Clinical Data
CRF: Neuropathology Data Form
Displaying 151 - 175 of 175
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guidance) | Subdomain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C15110 | Atherosclerotic luminal stenosis percentage range | AtheroLuminStenPercentRange | Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) | Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) | Yes, stentoic | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+=up to 30% stenosis;Moderate 2+=up to 50% stenosis;Severe 3+=up to 8-% stenosis;Very severe 4+=apparent occlusion | Alphanumeric |
This question is answered only if "Yes stenotic" is answered for "Are there atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis)?" |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15046 | Brain atrophy thalamus neuronal loss nuclei severity result | BrAtThalamusNeurLosNucSevReslt | Quantitative result of the severity of neuronal loss in thalamic nuclei | Quantitative result of the severity of neuronal loss in thalamic nuclei | Yes, neuronal loss | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Alphanumeric |
To be answered for each nuclei name |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08162 | National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale | NIAReaganInNeuropathCritScale | National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. | National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. | NIA/Reagan Institute neuropathological criteria likelihood of dementia being due to Alzheimer disease (AD) | Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available | Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08177 | Hemorrhage indicator | HemrrhgInd | Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain | Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain | Are there single or multiple hemorrhages? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15089 | Cortical infarcts single or multiple event category | CorInfarcSingMultiEventCat | Category of the cortical microinfarcts | Category of the cortical microinfarcts | If yes | Single;Multiple | Single;Multiple | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15025 | Brain atrophy striatum cerebellum status | BrAtStriatumCerebellumStat | Status of cerebellum atrophy in the striatum | Status of cerebellum atrophy in the striatu | Cerebellum atrophy | Absent;Present | Absent;Present | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C17759 | Striatum atrophy thalamus atrophy status | StrAtrophyThalamusAtrophyStat | Status of atrophy in the thalamus | Status of atrophy in the thalamu | Thalamus atrophy | Absent;Present | Absent;Present | Alphanumeric |
Striatum atrophy |
No references available | Adult | Supplemental | 3.00 | 2013-08-30 17:06:52.8 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18153 | Data unknown text | DataUnknwnTxt | The free-text field to Mark an "X" in to record if data are unknown or not available | The free-text field to Mark an "X" in to record if data are unknown or not availabl | CAG repeat HD-IT 15 CAG repeat expansion unknown | Alphanumeric |
If the size of the HD-IT 15 CAG expansion is unknown, record as Not Known in the next data element. |
Adult;Pediatric | Supplemental | 3.00 | 2013-07-17 09:26:36.973 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations | 20 |
Free-Form Entry |
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| C15057 | Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites status | BrAtSubNigraLeBodyLeNeurStat | Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra | Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigr | Lewy body containing neurons (LBCN) and Lewy neurites (LN) | Absent;Present | Absent;Present | Alphanumeric |
Substantia nigra |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15068 | Brain atrophy pontine nuclei globosum neuronal tangles (GNT) severity result | BrAtPontNucGloNeurTanSevReslt | Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei | Quantitative result of the severity of globosum neuronal tangles in the pontine nucle | Yes, neuronal loss | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Alphanumeric |
Pons: Neuronal loss |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C14976 | Brain atrophy surface severity result | BrainAtrophySurfSevReslt | Quantitative result of the severity of cerebral atrophy on external brain surface | Quantitative result of the severity of cerebral atrophy on external brain surface | Present | 0;1+/4+;2+/4+;3+/4+;4+/4+ | 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe | Alphanumeric |
This question is answered if "Present" is answered for "On gross examination of the external surface of the brain, cerebral atrophy". This question is answered for each of the brain anatomic sites. |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15100 | Cortical laminar necrosis single or multiple text | CortLaminarNecSingMultiTxt | The text description of the cortical laminar necrosis | The text description of the cortical laminar necrosis | Describe | Alphanumeric |
Answer for each vascular territory and event category |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C15036 | Brain atrophy neuronal loss and fibrillary astrocytosis pontes griseum or gray matter caudo-lenticular bridges anatomic site | BrAtNeLosFibAstroPonAntmicSite | Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present | Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present | Pontes griseum or gray matter caudo-lenticular bridges | Dorsal half;Ventral half | Dorsal half;Ventral half | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08149 | Diagnosis final clinical death type | DiagnosFinalClinDeathTyp | Physician's final clinical diagnosis for the participant/subject | Physician's final clinical diagnosis for the participant/subject | FINAL CLINICAL DIAGNOSIS BEFORE DETAH | Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease | Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C15079 | Brain atrophy cerebellum cortical neuronal loss in bergman gliosis status | BrAtCerebCortNeurLosBerGliStat | Status of cortical neuronal loss in the Bergman gliosis (BG) of the cerebellum | Status of cortical neuronal loss in the Bergman gliosis (BG) of the cerebellum | Bergman gliosis | Absent;Present | Absent;Present | Alphanumeric |
Cerebellum; Cortical neuronal loss |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C14987 | Brain atrophy striatum body of caudate nucleus (CN) severity result | BrAtStrCauNucBodySevReslt | Quantitative result of the severity of atrophy located in the body of the caudate nucleus (CN) (at the coronal section passing through the lateral geniculate body). | Quantitative result of the severity of atrophy located in the body of the caudate nucleus (CN) (at the coronal section passing through the lateral geniculate body). | Body of the CN | Mild 1+;Moderate 2+;Severe3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe3+;Very severe 4+ | Alphanumeric |
Striatum atrophy: At the coronal section passing through the lateral geniculate body: atrophy |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15111 | Arteriosclerosis severity score | ArteriosclerosisSevScore | Severity score for arteriosclerosis (small parenchymal arteriolar disease) | Severity score for arteriosclerosis (small parenchymal arteriolar disease) | Yes | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Alphanumeric |
This question is answered only if "Yes" is answered for "Is there arteriosclerosis (small parenchymal arteriolar disease)?" |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15047 | Brain atrophy subthalamic nucleus neuronal loss indicator | BrAtSubthalNucNeurLossInd | Indicator of neuronal loss in the subthalamic nucleus | Indicator of neuronal loss in the subthalamic nucleu | Subthalamic nucleus Neuronal loss | No neuronal loss;Yes neuronal loss | No neuronal loss;Yes neuronal loss | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08163 | CERAD neuropathological criteria scale | CERADNeuropathCritScale | CERAD neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease | Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease | CERAD neuropathological criteria (e.g., neuritic plaques) Alzheimer disease (AD) | Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown | Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08179 | Cortical laminar necrosis indicator | CortclLamnrNecrsisInd | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Is there cortical laminar necrosis? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15090 | Cortical infarcts single or multiple vascular territories name | CorInfarcSingMultiVasclTeName | Name of the vascular territories where cortical microinfarcts occur | Name of the vascular territories where cortical microinfarcts occur | Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) | ACA;MCA;PCA;Combined | ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; | Alphanumeric |
No additional instructions |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15026 | Brain atrophy cerebellum severity result | BrAtCerebellumSevReslt | Quantitative result of the severity of cerebellum atrophy located in the striatum | Quantitative result of the severity of cerebellum atrophy located in the striatu | Present | Mild 1+;Moderate 2+;Severe3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe3+;Very severe 4+ | Alphanumeric |
This question is answered if 'Present' is answered for 'Cerebellum atrophy' |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C17760 | Striatum atrophy thalamus atrophy severity result | StrAtrophyThalAtrophySevReslt | Quantitative result of the severity of atrophy located in the thalamus | Quantitative result of the severity of atrophy located in the thalam | Present | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Alphanumeric |
Striatum atrophy |
No references available | Adult | Supplemental | 3.00 | 2013-08-30 17:06:52.8 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18667 | Data source other text | DataSourcOTH | The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form | The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form | Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C15058 | Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites severity result | BrAtSubNigraLeCBodLeNeSevReslt | Quantitative result of the severity of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. | Quantitative result of the severity of Lewy-body containing neurons (LBCN) and Lewy neurites (LN) in the substantia nigra. | Present | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ | Alphanumeric |
Substantia nigra |
No references available | Adult | Supplemental | 3.00 | 2013-07-14 19:48:50.273 | Neuropathology Data Form | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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