CDE Detailed Report

Disease: Huntington's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 151 - 175 of 175
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C15076 Brain atrophy cerebellum cortical neuronal loss in receptive layer severity result BrAtCerCortNeuLosRecLaSevReslt Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14984 Brain atrophy coronal sections amygdala severity result BrAtCorSecAmygdalaSevReslt Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C15023 Brain atrophy striatum brainstem status BrAtStriatumBrainstemStat Status of brainstem atrophy in the striatum. Status of brainstem atrophy in the striatum. Brainstem atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

Kemper TL. Neuroanatomical and Neuropathological changes during aging and dementia, Second edn., Oxford University Press, New York, 1994, 3-67. Esiri MM and Morris JH. Practical approach to pathological diagnosis. In: Esiri MM, Lee VM-Y, Trojanowski JQ, eds. The neuropathology of dementia. First ed. Cambridge CB2 2RU, UK: Cambridge University Press; 2004:48-74. Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17757 Striatum atrophy hypothalamus atrophy status StrAtrophyHypothAtrophyStat Status of atrophy in the hypothalamus. Status of atrophy in the hypothalamus. Hypothalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15055 Brain atrophy substantia nigra pars reticulata neuronal loss indicator BrAtSubNiParsReticNeurLosInd Indicator of neuronal loss in the pars reticulata of the substantia nigra. Indicator of neuronal loss in the pars reticulata of the substantia nigra. Pars reticulata Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are there single or multiple cortical microinfarcts (each, <1.5cm in greatest dimension, including "granular atrophy")? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Cortical microinfarcts are defined as

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Single Pre-Defined Value Selected

C18994 Microscopical examination blocks other text MicroExamBlocksOTH The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain Other, specify Alphanumeric

Indicate the parts selected for evaluation

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Free-Form Entry

C15087 Ischemic or hemorrhagic vascular territories name IschHemVasclTerritoriesName Name of the vascular territories where ischemic or hemorrhagic changes occur Name of the vascular territories where ischemic or hemorrhagic changes occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15034 Brain atrophy amygdala neuronal loss severity result BrAtAmygdalaNeurLossSevReslt Quantitative result of the severity of neuronal loss in the amygdala. Quantitative result of the severity of neuronal loss in the amygdala. Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Amygdala neuronal loss'

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Single Pre-Defined Value Selected

C08147 Data source DataSource Source of the data provided on the case report form Source of the data provided on the case report form DATA SOURCE Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Alphanumeric

No additional instructions

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Multiple Pre-Defined Values Selected

C15066 Brain atrophy pons neuronal loss severity result BrAtPonsNeurLossSevReslt Quantitative result of the severity of neuronal loss in the pons Quantitative result of the severity of neuronal loss in the pons Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

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Single Pre-Defined Value Selected

C14974 Brain atrophy surface status BrainAtrophySurfStat Status of cerebral atrophy on external surface of the brain upon gross examination Status of cerebral atrophy on external surface of the brain upon gross examination On gross examination of the external surface of the brain, cerebral atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15098 Cortical laminar necrosis single or multiple event category CortLaminNecSingMultiEvntCat Category of the cortical laminar necrosis Category of the cortical laminar necrosis Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15109 Abnormality no diagnosis type AbnrmlyNoDiagTyp The diagnosis if there is no abnormality recognized The diagnosis if there is no abnormality recognized There is no diagnostic abnormality recognized Control brain;Huntington disease, grade 0 Control brain=If without neurological and psychiatric troubles, and without HD-IT15 CAG repeat expansion;Huntington disease, grade 0=If without neurological and psychiatric troubles, but with HD-IT15 CAG repeat expansion Alphanumeric

This question is answered only if "There is no diagnostic abnormality recognized" is answered for Final clinicopathological diagnosis.

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Single Pre-Defined Value Selected

C15045 Brain atrophy thalamus neuronal loss nuclei name BrAtThalamusNeurLossNucName Name of the nuclei in the thalamus involved in the neuronal loss Name of the nuclei in the thalamus involved in the neuronal loss If Yes, specify nuclei that are mainly involved Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C08160 Brain tissue weigh type BrainTissWeighedTyp Type of brain tissue weighed Type of brain tissue weighed Brain weight-Part weighed Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17764 Striatum atrophy red nucleus atrophy severity result StrAtrophyRedNuAtrophySevReslt Quantitative result of the severity of atrophy located in the red nucleus. Quantitative result of the severity of atrophy located in the red nucleus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15077 Brain atrophy cerebellum cortical neuronal loss in effective layer indicator BrAtCerebCortNeurLossEffLayInd Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Effective layer (Purknje cells) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14985 Brain atrophy striatum status BrAtStriatumStat Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Absent;Present Absent;Present Alphanumeric

Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy

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Single Pre-Defined Value Selected

C15024 Brain atrophy striatum brainstem severity result BrAtStriatBrainstemSevReslt Quantitative result of the severity of brainstem atrophy located in the striatum. Quantitative result of the severity of brainstem atrophy located in the striatum. Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

This question is answered if 'Present' is answered for 'Brainstem atrophy'

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Single Pre-Defined Value Selected

C17758 Striatum atrophy hypothalamus atrophy severity result StrAtrophyHypoAtrophySevReslt Quantitative result of the severity of atrophy located in the hypothalamus. Quantitative result of the severity of atrophy located in the hypothalamus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15056 Brain atrophy substantia nigra pars reticulata neuronal loss severity result BrAtSubNiParsRetNeuLosSevReslt Quantitative result of the severity of neuronal loss in the pars reticulata. Quantitative result of the severity of neuronal loss in the pars reticulata. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C08176 Lacunes single or multiple indicator LacunesSingMultiInd Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matter Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels. Are there single or multiple lacunes (each > 1,5cm, but = 2c, small artery infarcts Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Lacunes are defined as > 1.5cm each but = 2 cm small artery infarcts.

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Single Pre-Defined Value Selected

C18995 Brain atrophy thalamus neuronal loss nuclei other text BrAtThalamusNeurLossNucOTH The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss Other, specify Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C15088 Ischemic or hemorrhagic changes description text IschHemChangesDescriptTxt The text description of the ischemic or hemorrhagic changes The text description of the ischemic or hemorrhagic changes Describe Alphanumeric

Answer for each vascular territory and event category

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Free-Form Entry

CSV