CDE Detailed Report

Disease: Huntington's Disease
Subdomain Name: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 151 - 175 of 175
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C14992 Brain atrophy striatum status cribrosus or lacunaris severity result BrAtStrStatusCribLacunSevReslt Quantitative result of the severity of atrophy located in the status cribrosus or lacunaris, or both Quantitative result of the severity of atrophy located in the status cribrosus or lacunaris, or bot Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C17754 Microscopic examination brain text MicroExamBrainTxt Note regarding microscopic examination of blockage source Note regarding microscopical examination of blockage source Microscopical examination Note Alphanumeric No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C18997 Clinicopathology diagnosis final other text ClinicopathDiagnosFinalOTH the free-text related to 'Clinicopathology diagnosis final type' specifying other text. The participant/subject's final clinicopathological diagnosis the free-text related to 'Clinicopathology diagnosis final type' specifying other text. The participant/subject's final clinicopathological diagnosis Other, specify Alphanumeric

No additional instructions

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C15052 Brain atrophy cerebral white matter myelin loss severity result BrAtCereWMMyelinLosSevReslt Quantitative result of the cerebral white matter myelin loss Quantitative result of the cerebral white matter myelin loss Yes, myelin loss 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if "Yes, myelin loss" is answered for 'Cerebral white matter: myelin loss". This question is answered for each brain anatomic site.

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Single Pre-Defined Value Selected

C15063 Brain atrophy nucleus coeruleus globosum neuronal tangles status BrAtNucCoerGloNeurTanglesStat Status of globosum neuronal tangles (GNT) in the nucleus coeruleus Status of globosum neuronal tangles (GNT) in the nucleus coeruleu Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C14971 Macroscopical examination fresh brain source MacroExamFreshBrainSource The part(s) of the fresh brain used for macroscopical examination The part(s) of the fresh brain used for macroscopical examination Macroscopical examination Fresh Whole brain;Left half brain;Right half brain;Not available;Other specify Whole brain;Left half brain;Right half brain;Not available;Other specify Alphanumeric

Indicate the parts selected for evaluation

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Single Pre-Defined Value Selected

C15095 Hemorrhages single or multiple event category HemorrhageSingMultiEvntCat Category of the hemorrhages Category of the hemorrhages Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15031 Brain atrophy hippocampal formation neuronal loss indicator BrAtHippocampFormNeurLossInd Indicator of neuronal loss in the hippocampal formation Indicator of neuronal loss in the hippocampal formatio Hippocampal formation Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C02411 Laterality type LatTyp Laterality type relative to the anatomic site of the body examined or affected Laterality type relative to the anatomic site of the body examined or affected Bilateral;Left;Right;Unknown Bilateral;Left;Right;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15074 Brain atrophy cerebellum cortical neuronal loss in associative layer severity result BrAtCerCortNeurLosAsocSevReslt Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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C14982 Brain atrophy coronal sections hippocampal formation severity result BrAtCorSecHippFormSevReslt Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15106 Clinicopathology diagnosis final type ClinicopathDiagnosFinalTyp The participant/subject's final clinicopathological diagnosis The participant/subject's final clinicopathological diagnosis Yes Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17767 Striatum atrophy hydrocephalus fourth ventricle severity result StrAtrophyHydroFoVentSevReslt Quantitative result of the severity of hydrocephalus located in the fourth ventricle Quantitative result of the severity of hydrocephalus located in the fourth ventricl Fourth ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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Single Pre-Defined Value Selected

C15042 Brain atrophy fibrillary astrocytosis severity result BrAtFibAstroSevReslt Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Yes, neuronal loss 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

Answer for caudate nucleus, pontes griseum or gray matter caudo-lenticular bridges, putamen, and globus pallidus anatomic sites.

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Single Pre-Defined Value Selected

C08156 Specimen other postmortem indicator SpecmnOtherPstmortemInd Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Are other banked postmortem specimens available? (e.g. blood, spinal cord, nerve, muscle) Yes;No Yes;No Alphanumeric

If YES is answered then explain what other type(s) of postmortem samples exist

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Single Pre-Defined Value Selected

C08171 Diffuse plaques density category DiffusePlaqDenstyCat Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Immatue and diffuse type plaques (are plaques without the dense core of the neuritic plaques and are either with [immature] or without [diffuse] dystrophic neurites) No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown Alphanumeric

Amyloid plaques

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Single Pre-Defined Value Selected

C15085 Silver staining methods type SilverStainMethdsTyp Silver staining methods used for identifying Alzheimer disease type changes Silver staining methods used for identifying Alzheimer disease type changes Silver methods Bielschowsky;Other, specify;Not assessed;Missing/Unknown Bielschowsky;Other, specify;Not assessed;Missing/Unknown Alphanumeric

Answer for each type of microscopic brain abnormality

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Single Pre-Defined Value Selected

C15021 Brain atrophy substantia nigra appearance grade BrAtSubstantiaNigraAppGrade Grade of pigmentation of the substantia nigra Grade of pigmentation of the substantia nigra Substantia nigra Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C17755 Striatum atrophy claustrum atrophy status StrAtrophyClaustrumAtrophyStat Status of atrophy in the claustrum Status of atrophy in the claustru Claustrum atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15053 Brain atrophy substantia nigra pars compacta neuronal loss indicator BrAtSubNigraParsCompNeurLosInd Indicator of neuronal loss in the pars compacta of the substantia nigra Indicator of neuronal loss in the pars compacta of the substantia nigr Pars compacta Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

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C15064 Brain atrophy nucleus coeruleus globosum neuronal tangles (GNT) severity result BrAtNucCoerGloNeurTanSevReslt Quantitative result of the severity of GNT in the nucleus coeruleus Quantitative result of the severity of GNT in the nucleus coeruleu Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C14972 Macroscopical examination fixed brain source MacroExamFixedBrainSource The part(s) of the fixed brain used for macroscopical examination The part(s) of the fixed brain used for macroscopical examination Macroscopical examination Fixed Whole brain;Left half brain;Right half brain;Not available;Other, specify Whole brain;Left half brain;Right half brain;Not available;Other, specify Alphanumeric

Indicate the parts selected for evaluation

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Single Pre-Defined Value Selected

C15096 Hemorrhages single or multiple vascular territories name HemSingMultiVascTerrName Name of the vascular territories where hemorrhages occur Name of the vascular territories where hemorrhages occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15032 Brain atrophy hippocampal formation neuronal loss severity result BrAtHippocFormNeurLossSevReslt Quantitative result of the severity of neuronal loss in the hippocampal formation Quantitative result of the severity of neuronal loss in the hippocampal formation Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Hippocampal formation neuronal loss'

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Single Pre-Defined Value Selected

C04802 Death date and time DeathDateTime Date (and time, if known) of participant's/subject's death Date (and time, if known) of participant's/subject's death Date of Death; Time of Death Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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2004152
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