CDE Detailed Report

Disease: Huntington's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 51 - 100 of 175
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C15076 Brain atrophy cerebellum cortical neuronal loss in receptive layer severity result BrAtCerCortNeuLosRecLaSevReslt Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14984 Brain atrophy coronal sections amygdala severity result BrAtCorSecAmygdalaSevReslt Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15108 Diagnoses final clinicopathological severity scale DiagnosFinClinicopathSevScale Scale of the severity or intensity of the diagnosis Scale of the severity or intensity of the diagnosis Final Clinicopathological Diagnosis Mild;Moderate;Severe Mild;Moderate;Severe Alphanumeric

Only answered if "Encephalopathy of hypoxic-ischemic type, acute", "Alzheimer changes", or "Status cribrosus and lacunaris" are answered for Final Clinicopathological diagnoses

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17757 Striatum atrophy hypothalamus atrophy status StrAtrophyHypothAtrophyStat Status of atrophy in the hypothalamus. Status of atrophy in the hypothalamus. Hypothalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15055 Brain atrophy substantia nigra pars reticulata neuronal loss indicator BrAtSubNiParsReticNeurLosInd Indicator of neuronal loss in the pars reticulata of the substantia nigra. Indicator of neuronal loss in the pars reticulata of the substantia nigra. Pars reticulata Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are there single or multiple cortical microinfarcts (each, <1.5cm in greatest dimension, including "granular atrophy")? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Cortical microinfarcts are defined as

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15087 Ischemic or hemorrhagic vascular territories name IschHemVasclTerritoriesName Name of the vascular territories where ischemic or hemorrhagic changes occur Name of the vascular territories where ischemic or hemorrhagic changes occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15023 Brain atrophy striatum brainstem status BrAtStriatumBrainstemStat Status of brainstem atrophy in the striatum. Status of brainstem atrophy in the striatum. Brainstem atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

Kemper TL. Neuroanatomical and Neuropathological changes during aging and dementia, Second edn., Oxford University Press, New York, 1994, 3-67. Esiri MM and Morris JH. Practical approach to pathological diagnosis. In: Esiri MM, Lee VM-Y, Trojanowski JQ, eds. The neuropathology of dementia. First ed. Cambridge CB2 2RU, UK: Cambridge University Press; 2004:48-74. Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15034 Brain atrophy amygdala neuronal loss severity result BrAtAmygdalaNeurLossSevReslt Quantitative result of the severity of neuronal loss in the amygdala. Quantitative result of the severity of neuronal loss in the amygdala. Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Amygdala neuronal loss'

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08147 Data source DataSource Source of the data provided on the case report form Source of the data provided on the case report form DATA SOURCE Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C15066 Brain atrophy pons neuronal loss severity result BrAtPonsNeurLossSevReslt Quantitative result of the severity of neuronal loss in the pons Quantitative result of the severity of neuronal loss in the pons Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14974 Brain atrophy surface status BrainAtrophySurfStat Status of cerebral atrophy on external surface of the brain upon gross examination Status of cerebral atrophy on external surface of the brain upon gross examination On gross examination of the external surface of the brain, cerebral atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15098 Cortical laminar necrosis single or multiple event category CortLaminNecSingMultiEvntCat Category of the cortical laminar necrosis Category of the cortical laminar necrosis Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18993 Macroscopical examination fixed brain other text MacroExamFixedBrainOTH The free-text field related to 'Macroscopical examination fixed brain source' specifying other text. The part(s) of the fixed brain used for macroscopical examination The free-text field related to 'Macroscopical examination fixed brain source' specifying other text. The part(s) of the fixed brain used for macroscopical examination Other, specify Alphanumeric

Indicate the parts selected for evaluation

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C15045 Brain atrophy thalamus neuronal loss nuclei name BrAtThalamusNeurLossNucName Name of the nuclei in the thalamus involved in the neuronal loss Name of the nuclei in the thalamus involved in the neuronal loss If Yes, specify nuclei that are mainly involved Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C08160 Brain tissue weigh type BrainTissWeighedTyp Type of brain tissue weighed Type of brain tissue weighed Brain weight-Part weighed Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15077 Brain atrophy cerebellum cortical neuronal loss in effective layer indicator BrAtCerebCortNeurLossEffLayInd Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Effective layer (Purknje cells) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14985 Brain atrophy striatum status BrAtStriatumStat Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Absent;Present Absent;Present Alphanumeric

Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15109 Abnormality no diagnosis type AbnrmlyNoDiagTyp The diagnosis if there is no abnormality recognized The diagnosis if there is no abnormality recognized There is no diagnostic abnormality recognized Control brain;Huntington disease, grade 0 Control brain=If without neurological and psychiatric troubles, and without HD-IT15 CAG repeat expansion;Huntington disease, grade 0=If without neurological and psychiatric troubles, but with HD-IT15 CAG repeat expansion Alphanumeric

This question is answered only if "There is no diagnostic abnormality recognized" is answered for Final clinicopathological diagnosis.

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17758 Striatum atrophy hypothalamus atrophy severity result StrAtrophyHypoAtrophySevReslt Quantitative result of the severity of atrophy located in the hypothalamus. Quantitative result of the severity of atrophy located in the hypothalamus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15056 Brain atrophy substantia nigra pars reticulata neuronal loss severity result BrAtSubNiParsRetNeuLosSevReslt Quantitative result of the severity of neuronal loss in the pars reticulata. Quantitative result of the severity of neuronal loss in the pars reticulata. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08176 Lacunes single or multiple indicator LacunesSingMultiInd Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matter Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels. Are there single or multiple lacunes (each > 1,5cm, but = 2c, small artery infarcts Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Lacunes are defined as > 1.5cm each but = 2 cm small artery infarcts.

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15088 Ischemic or hemorrhagic changes description text IschHemChangesDescriptTxt The text description of the ischemic or hemorrhagic changes The text description of the ischemic or hemorrhagic changes Describe Alphanumeric

Answer for each vascular territory and event category

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C15024 Brain atrophy striatum brainstem severity result BrAtStriatBrainstemSevReslt Quantitative result of the severity of brainstem atrophy located in the striatum. Quantitative result of the severity of brainstem atrophy located in the striatum. Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

This question is answered if 'Present' is answered for 'Brainstem atrophy'

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15035 Brain atrophy neuronal loss fibrillary astrocytosis caudate nucleus anatomic site BrAtNeLosFibAstCauNuAntmicSite Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Is there evidence of neuronal loss and fibrillary astrocytosis? (caudate nucleus[CN], putamen, globus pallidus and nucleus accumbens Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08148 Neuropath specimen identifier number NeuropthSpecmnIDNum Unique identification number given to the neuropathology specimen Unique identification number given to the neuropathology specimen Neuropath ID Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C15067 Brain atrophy pontine nuclei globosum neuronal tangles status BrAtPontineNucGloNeurTanStat Status of globosum neuronal tangles (GNT) in the pontine nuclei. Status of globosum neuronal tangles (GNT) in the pontine nuclei. Pontine nuclei Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Pons: Neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14975 Brain lobe examination anatomic site BrainLobeAExamAntmicSite Anatomic site examined in the brain Anatomic site examined in the brain If yes Frontal;Parietal;Temporal;Occipital Frontal;Parietal;Temporal;Occipital Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15099 Cortical laminar necrosis single or multiple vascular territories name CortLaNecSingMultiVasTerName Name of the vascular territories where cortical laminar necrosis occurs Name of the vascular territories where cortical laminar necrosis occurs Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18994 Microscopical examination blocks other text MicroExamBlocksOTH The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain Other, specify Alphanumeric

Indicate the parts selected for evaluation

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C15046 Brain atrophy thalamus neuronal loss nuclei severity result BrAtThalamusNeurLosNucSevReslt Quantitative result of the severity of neuronal loss in thalamic nuclei Quantitative result of the severity of neuronal loss in thalamic nuclei Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

To be answered for each nuclei name

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08162 National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale NIAReaganInNeuropathCritScale National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. NIA/Reagan Institute neuropathological criteria likelihood of dementia being due to Alzheimer disease (AD) Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15078 Brain atrophy cerebellum cortical neuronal loss in effective layer severity result BrAtCerCortNeuLosEffLaSevReslt Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14986 Brain atrophy striatum head of caudate nucleus severity result BrAtStrCauNucHeadSevReslt Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Head of the CN Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: At the level where the anterior limb of the internal capsule (ALIC) joins with the basal white matter:atrophy

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15110 Atherosclerotic luminal stenosis percentage range AtheroLuminStenPercentRange Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Yes, stentoic Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+=up to 30% stenosis;Moderate 2+=up to 50% stenosis;Severe 3+=up to 8-% stenosis;Very severe 4+=apparent occlusion Alphanumeric

This question is answered only if "Yes stenotic" is answered for "Are there atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis)?"

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17759 Striatum atrophy thalamus atrophy status StrAtrophyThalamusAtrophyStat Status of atrophy in the thalamus. Status of atrophy in the thalamus. Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15057 Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites status BrAtSubNigraLeBodyLeNeurStat Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. Lewy body containing neurons (LBCN) and Lewy neurites (LN) Absent;Present Absent;Present Alphanumeric

Substantia nigra

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08177 Hemorrhage indicator HemrrhgInd Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Are there single or multiple hemorrhages? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15089 Cortical infarcts single or multiple event category CorInfarcSingMultiEventCat Category of the cortical microinfarcts Category of the cortical microinfarcts If yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17764 Striatum atrophy red nucleus atrophy severity result StrAtrophyRedNuAtrophySevReslt Quantitative result of the severity of atrophy located in the red nucleus. Quantitative result of the severity of atrophy located in the red nucleus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15025 Brain atrophy striatum cerebellum status BrAtStriatumCerebellumStat Status of cerebellum atrophy in the striatum. Status of cerebellum atrophy in the striatum. Cerebellum atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15036 Brain atrophy neuronal loss and fibrillary astrocytosis pontes griseum or gray matter caudo-lenticular bridges anatomic site BrAtNeLosFibAstroPonAntmicSite Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Pontes griseum or gray matter caudo-lenticular bridges Dorsal half;Ventral half Dorsal half;Ventral half Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08149 Diagnosis final clinical death type DiagnosFinalClinDeathTyp Physician's final clinical diagnosis for the participant/subject Physician's final clinical diagnosis for the participant/subject FINAL CLINICAL DIAGNOSIS BEFORE DETAH Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C15068 Brain atrophy pontine nuclei globosum neuronal tangles (GNT) severity result BrAtPontNucGloNeurTanSevReslt Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei. Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C14976 Brain atrophy surface severity result BrainAtrophySurfSevReslt Quantitative result of the severity of cerebral atrophy on external brain surface Quantitative result of the severity of cerebral atrophy on external brain surface Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if "Present" is answered for "On gross examination of the external surface of the brain, cerebral atrophy". This question is answered for each of the brain anatomic sites.

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15100 Cortical laminar necrosis single or multiple text CortLaminarNecSingMultiTxt The text description of the cortical laminar necrosis The text description of the cortical laminar necrosis Describe Alphanumeric

Answer for each vascular territory and event category

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C18995 Brain atrophy thalamus neuronal loss nuclei other text BrAtThalamusNeurLossNucOTH The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss Other, specify Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C15111 Arteriosclerosis severity score ArteriosclerosisSevScore Severity score for arteriosclerosis (small parenchymal arteriolar disease) Severity score for arteriosclerosis (small parenchymal arteriolar disease) Yes Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered only if "Yes" is answered for "Is there arteriosclerosis (small parenchymal arteriolar disease)?"

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15047 Brain atrophy subthalamic nucleus neuronal loss indicator BrAtSubthalNucNeurLossInd Indicator of neuronal loss in the subthalamic nucleus. Indicator of neuronal loss in the subthalamic nucleus. Subthalamic nucleus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08163 CERAD neuropathological criteria scale CERADNeuropathCritScale CERAD neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease CERAD neuropathological criteria (e.g., neuritic plaques) Alzheimer disease (AD) Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric

No additional instructions

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

CSV