CDE Detailed Report

Disease: Huntington's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 1 - 50 of 175
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C15059 Brain atrophy nucleus coeruleus neuronal loss indicator BrAtNucCoerNeurLossInd Indicator of neuronal loss in the nucleus coeruleus. Indicator of neuronal loss in the nucleus coeruleus. Nucleus coeruleus No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C08181 Other pathology ischemic vascular disease indicator OthrPathlgyIschmcVasclrDisInd Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Are there other vascular-depending changes, which are not previously specified? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

If yes, specify other

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C15091 Cortical infarcts single or multiple description text CorInfarcSingMultiDescriptTxt The text description of the cortical microinfarcts The text description of the cortical microinfarcts Describe Alphanumeric

Answer for each vascular territory and event category

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C15027 Brain atrophy cortex neuronal loss indicator BrAtCerebralCortexNeurLossInd Indicator of neuronal loss in the cerebral cortex Indicator of neuronal loss in the cerebral cortex Cerebral cortex Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17761 Striatum atrophy subthalamic nucleus atrophy status StrAtrophySubthalNuAtrophyStat Status of atrophy in the subthalamic nucleus. Status of atrophy in the subthalamic nucleus. Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C08152 Brain tissue frozen indicator BrainTissFrozenInd Indicator of whether banked frozen brain tissue is accessible Indicator of whether banked frozen brain tissue is accessible Is banked frozen brain tissue available? Yes;No Yes;No Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15070 Brain atrophy medulla oblongata dorsal nucleus of vagus reticular formation severity result BrAtMedObDorNucVagRetFSevReslt Quantitative result of the severity of dorsal nucleus of vagus reticular formation: LBCN and LN in the medulla oblongata Quantitative result of the severity of dorsal nucleus of vagus reticular formation: LBCN and LN in the medulla oblongata Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Medulla oblongata

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C14978 Brain atrophy coronal sections cerebral cortex severity result BrainAtCorSecCereCorSevReslt Quantitative result of the severity of cerebral cortex atrophy in the coronal sections of the brain Quantitative result of the severity of cerebral cortex atrophy in the coronal sections of the brain Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C18667 Data source other text DataSourcOTH The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form Other, specify Alphanumeric

No additional instructions

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C15102 Arteriosclerosis indicator ArteriosclerosisInd Indicator of arteriosclerosis (small parenchymal arteriolar disease) Indicator of arteriosclerosis (small parenchymal arteriolar disease) Is there arteriosclerosis (small parenchymal arteriolar disease)? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15038 Brain atrophy neuronal loss nucleus accumbens severity result BrAtNeurLossNucAccSevReslt Quantitative result of the severity of neuronal loss in the nucleus accumbens Quantitative result of the severity of neuronal loss in the nucleus accumbens Nucleus accumbens 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15049 Brain atrophy red nucleus neuronal loss indicator BrAtRedNucNeurLossInd Indicator of neuronal loss in the red nucleus. Indicator of neuronal loss in the red nucleus. Red nucleus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08167 Brain abnormality microscopic type BrainAbnrmlyMicroscpcTyp Type of microscopic brain abnormality identified through staining Type of microscopic brain abnormality identified through staining Staining methods use for Tangles;Plaques;Lewy bodies;TDP-43 Tangles;Plaques;Lewy bodies;TDP-43 Alphanumeric

For each type of microscopic brain abnormality record the staining methods for immunohistochemistry (IHC) and antibodies

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Single Pre-Defined Value Selected

C15081 Brain atrophy cerebellum myelin loss in cerebellar white matter severity result BrAtCerMyeLosCerWMSevReslt Quantitative result of the severity of myelin loss in the cerebellar white matter of the cerebellum. Quantitative result of the severity of myelin loss in the cerebellar white matter of the cerebellum. Yes, myelin loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cerebellar white matter: Myelin loss

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Single Pre-Defined Value Selected

C14989 Brain atrophy striatum globus pallidus external segment severity result BrAtStrGlPaExternlSevReslt Quantitative result of the severity of atrophy located in the globus pallidus, external segment. Quantitative result of the severity of atrophy located in the globus pallidus, external segment. External segment atrophy Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy; Globus pallidus

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C17400 Other pathology ischemic vascular disease text OthrPathlgyIschmcVasclrDisTxt Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Yes, specify Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2012-12-20 00:00:00.0 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C15060 Brain atrophy nucleus coeruleus neuronal loss severity result BrAtNucCoerNeurLossSevReslt Quantitative result of the severity of neuronal loss in the nucleus coeruleus Quantitative result of the severity of neuronal loss in the nucleus coeruleus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C08185 Amyloid angiopathy severity scale AmyldAngpthySevScale Whether or not amyloid deposits are present in the walls of the blood vessels of the central nervous system and if so, their severity. Whether or not amyloid deposits are present in the walls of the blood vessels of the central nervous system and if so, their severity. Yes None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

This question is answered only if "Yes" is answered for "Is cerebral amyloid angiopathy present?"

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Single Pre-Defined Value Selected

C15092 Lacunes single or multiple event category LacunesSingMultiEvntCat Category of the lacunes Category of the lacunes Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15028 Brain atrophy cerebral cortex neuronal loss severity result BrAtCereCortexNeurLossSevReslt Quantitative result of the severity of neuronal loss located in the cerebral cortex. Quantitative result of the severity of neuronal loss located in the cerebral cortex. Yes, neuronal loss 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered for each of the brain anatomic sites.

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C17762 Striatum atrophy subthalamic nucleus atrophy severity result StrAtrophySubNuAtrophySevReslt Quantitative result of the severity of atrophy located in the subthalamic nucleus. Quantitative result of the severity of atrophy located in the subthalamic nucleus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C08153 Brain tissue formalin-fixed indicator BrainTissFormalinFixedInd Indicator of whether formalin-fixed brain tissue is accessible Indicator of whether formalin-fixed brain tissue is accessible Is formalin-fixed brain tissue available? Yes;No Yes;No Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15071 Brain atrophy medulla oblongata inferior olivary nucleus indicator BrAtMedObInfOlivaryNucInd Indicator of neuronal loss of the inferior olivary nucleus in the medulla oblongata Indicator of neuronal loss of the inferior olivary nucleus in the medulla oblongata Inferior olivary nucleus No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Medulla oblongata

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C14979 Brain atrophy coronal sections cerebral white matter status BrainAtCorSecCerWMStat Status of cerebral white matter atrophy of the coronal section upon gross examination. Status of cerebral white matter atrophy of the coronal section upon gross examination. Cerebral white matter atrophy Absent;Present Absent;Present Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C18669 Diagnosis final clinical death other text DiagnosFinalClinDeathOTH The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject Other, specify Alphanumeric

No additional instructions

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C15103 Amyloid angiopathy indicator AmyloidAngiopathyInd Indicator of presence of cerebral amyloid angiopathy Indicator of presence of cerebral amyloid angiopathy Is cerebral amyloid angiopathy present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15039 Brain atrophy fibrillary astrocytosis nucleus accumbens severity result BrAtFibAstroNucAccSevReslt Quantitative result of the severity of firbrillary astrocytosis in the nucleus accumbens Quantitative result of the severity of fibrillary astrocytosis in the nucleus accumbens Nucleus accumbens 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15050 Brain atrophy red nucleus neuronal loss severity result BrAtRedNucneurLossSevReslt Quantitative result of the severity of neuronal loss in the red nucleus Quantitative result of the severity of neuronal loss in the red nucleus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered if "Yes, neuronal loss" is answered for 'Red nucleus: neuronal loss"

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Single Pre-Defined Value Selected

C08168 Immunohistochemistry stain method name ImmunhistchmstryStainMethdName Name of staining method used for immunohistochemistry Name of staining method used for immunohistochemistry Immunochemistry Alphanumeric

Answer for each type of microscopic brain abnormality

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C15082 Brain atrophy cerebellum dentate nucleus neuronal loss indicator BrAtCerebDenNucNeurLosInd Indicator of neuronal loss in the dentate nucleus of the cerebellum Indicator of neuronal loss in the dentate nucleus of the cerebellum Dentate nucleus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Cerebellum; Dentate nucleus: Neuronal loss

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Single Pre-Defined Value Selected

C14990 Brain atrophy striatum globus pallidus internal segment severity result BrAtStrGlPaIntrnlSevReslt Quantitative result of the severity of atrophy located in the globus pallidus, internal segment. Quantitative result of the severity of atrophy located in the globus pallidus, internal segment. Internal segment atrophy Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy; Globus Pallidus

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Single Pre-Defined Value Selected

C17752 Photographs macroscopic text PhotographsMacroscopicTxt Description of available macroscopic photographs Description of available macroscopic photographs Yes(Describe…) Alphanumeric No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C15061 Brain atrophy nucleus coeruleus Lewy body containing neurons Lewy neurites status BrAtNucCoerLewyBodLewyNeuStat Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the nucleus coeruleus. Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the nucleus coeruleus. Lewy body-containing neurons (LBCN) and Lewy neurites (LN) Absent;Present Absent;Present Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C14969 Cytosine adenine guanine repeat expansion result CAGRepeatExpansionReslt Size of expansion of HD-IT 15 cytosine adenine guanine (CAG) repeats Size of expansion of HD-IT 15 cytosine adenine guanine (CAG) repeats CAG repeat HD-IT 15 CAG repeat expansion Numeric Values

If the size of the HD-IT 15 CAG expansion is unknown, record as Not Known in the next data element.

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C15093 Lacunes singe or multiple vascular territories name LacunesSingMultiVasclTerName Name of the vascular territories where lacunes occur Name of the vascular territories where lacunes occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15029 Brain atrophy cortical neuronal nuclear inclusions indicator BrAtCorticalNeurNucleIncInd Indicator of the presence of cortical neuronal nuclear inclusions (dystrophic neurites) Indicator of the presence of cortical neuronal nuclear inclusions (dystrophic neurites) Cortical neuronal nuclear inclusions-dystrophic neurites Absent;Present;Not assessed Absent;Present;Not assessed Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17763 Striatum atrophy red nucleus atrophy status StrAtrophyRedNuAtrophyStat Status of atrophy in the red nucleus. Status of atrophy in the red nucleus. Red nucleus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C00007 Birth date BirthDate Date (and time, if applicable and known) the participant/subject was born Date (and time, if applicable and known) the participant/subject was born Date of Birth Date or Date & Time

Record the date of birth to the level of precision known (e.g., month/day/year, year, month/year, etc). The preferred format for recording date is mm/dd/yyyy. 99/99/9999 can be used to indicate an unknown date.

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793
C08154 Brain tissue paraffin-embedded indicator BrainTissParaffinEmbeddedInd Indicator of whether paraffin-embedded blocks of brain tissue are accessible Indicator of whether paraffin-embedded blocks of brain tissue are accessible Are paraffin-embedded blocks of brain tissue available? Yes;No Yes;No Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15072 Brain atrophy medulla oblongata inferior olivary nucleus severity result BrAtMedObInfOlivaryNucSevReslt Quantitative result of the severity of neuronal loss in the inferior olivary nucleus Quantitative result of the severity of neuronal loss in the inferior olivary nucleus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Medulla oblongata

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C14980 Brain atrophy coronal sections cerebral white matter severity result BrainAtCorSecCerWMSevReslt Quantitative result of the severity of cerebral white matter atrophy in the coronal sections of the brain Quantitative result of the severity of cerebral white matter atrophy in the coronal sections of the brain Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C18741 Other pathology ischemic vascular disease specify text OthrPathlgyIschmcVasclrDisST The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Other, specify Alphanumeric

If yes, specify other

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C15104 Amyloid angiopathy stain type AmyloidAngiopathyStainTyp Type of stain used to identify cerebral amyloid angiopathy Type of stain used to identify cerebral amyloid angiopathy If, yes Congo red;Beta-amyloid Congo red;Beta-amyloid Alphanumeric

This question is answered only if "Yes" is answered for "Is cerebral amyloid angiopathy present?"

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C15040 Brain atrophy neuronal loss and fibrillary astrocytosis globus pallidus anatomic site BrAtNeuLosFibAstroGPAntmicSite Anatomic site in the globus pallidus where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the globus pallidus where neuronal loss and/or fibrillary astrocytosis is/are present Globus pallidus Lateral;Medial Lateral;Medial Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15051 Brain atrophy cerebral white matter myelin loss indicator BrAtCereWMMyelinLossInd Indicator of myelin loss in the cerebral white matter Indicator of myelin loss in the cerebral white matter Cerebral white matter Myelin loss No myelin loss;Yes myelin loss No myelin loss;Yes myelin loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08169 Antibody stain method name AntibdyStainMethdName Name of staining method used for antibodies Name of staining method used for antibodies Antibodies Alphanumeric

Answer for each type of microscopic brain abnormality

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C15083 Brain atrophy cerebellum dentate nucleus neuronal loss severity result BrAtCerebDenNucNeurLosSevReslt Quantitative result of the severity of neuronal loss in the dentate nucleus of the cerebellum. Quantitative result of the severity of neuronal loss in the dentate nucleus of the cerebellum. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Dentate nucleus: Neuronal loss

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C14991 Brain atrophy striatum status cribrosus lacunaris status BrAtStrStatusCribLacStat Status of atrophy in the status cribrosus or lacunaris. Status of atrophy in the status cribrosus or lacunaris. Status cribrosus or lucanaris, or both Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C17753 Macroscopic examination brain text MacroExamBrainTxt Note regarding macroscopic examination of fresh or fixed brain parts Note regarding macroscopical examination of fresh or fixed brain parts Macroscopical examination Note Alphanumeric No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C00035 Gender type GenderTyp Self-reported gender of the participant/subject. Self-reported gender of the participant/subject.. Gender Alphanumeric

Choose one

The NIH Guidelines on Inclusion of Women and Minorities as Subjects in Clinical Research: The Office of Management and Budget Directive No. 15 (http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm) Adult;Pediatric Core 3.00 2013-08-28 16:08:00.453 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

2200604
CSV