CDE Detailed Report

Disease: Huntington's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 1 - 50 of 175
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C14975 Brain lobe examination anatomic site BrainLobeAExamAntmicSite Anatomic site examined in the brain Anatomic site examined in the brain If yes Frontal;Parietal;Temporal;Occipital Frontal;Parietal;Temporal;Occipital Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15099 Cortical laminar necrosis single or multiple vascular territories name CortLaNecSingMultiVasTerName Name of the vascular territories where cortical laminar necrosis occurs Name of the vascular territories where cortical laminar necrosis occurs Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15035 Brain atrophy neuronal loss fibrillary astrocytosis caudate nucleus anatomic site BrAtNeLosFibAstCauNuAntmicSite Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Is there evidence of neuronal loss and fibrillary astrocytosis? (caudate nucleus[CN], putamen, globus pallidus and nucleus accumbens Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08148 Neuropath specimen identifier number NeuropthSpecmnIDNum Unique identification number given to the neuropathology specimen Unique identification number given to the neuropathology specimen Neuropath ID Alphanumeric

No additional instructions

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C15067 Brain atrophy pontine nuclei globosum neuronal tangles status BrAtPontineNucGloNeurTanStat Status of globosum neuronal tangles (GNT) in the pontine nuclei. Status of globosum neuronal tangles (GNT) in the pontine nuclei. Pontine nuclei Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Pons: Neuronal loss

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Single Pre-Defined Value Selected

C15078 Brain atrophy cerebellum cortical neuronal loss in effective layer severity result BrAtCerCortNeuLosEffLaSevReslt Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14986 Brain atrophy striatum head of caudate nucleus severity result BrAtStrCauNucHeadSevReslt Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Head of the CN Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: At the level where the anterior limb of the internal capsule (ALIC) joins with the basal white matter:atrophy

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Single Pre-Defined Value Selected

C15110 Atherosclerotic luminal stenosis percentage range AtheroLuminStenPercentRange Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Yes, stentoic Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+=up to 30% stenosis;Moderate 2+=up to 50% stenosis;Severe 3+=up to 8-% stenosis;Very severe 4+=apparent occlusion Alphanumeric

This question is answered only if "Yes stenotic" is answered for "Are there atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis)?"

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Single Pre-Defined Value Selected

C15046 Brain atrophy thalamus neuronal loss nuclei severity result BrAtThalamusNeurLosNucSevReslt Quantitative result of the severity of neuronal loss in thalamic nuclei Quantitative result of the severity of neuronal loss in thalamic nuclei Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

To be answered for each nuclei name

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Single Pre-Defined Value Selected

C08162 National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale NIAReaganInNeuropathCritScale National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. NIA/Reagan Institute neuropathological criteria likelihood of dementia being due to Alzheimer disease (AD) Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15089 Cortical infarcts single or multiple event category CorInfarcSingMultiEventCat Category of the cortical microinfarcts Category of the cortical microinfarcts If yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15025 Brain atrophy striatum cerebellum status BrAtStriatumCerebellumStat Status of cerebellum atrophy in the striatum. Status of cerebellum atrophy in the striatum. Cerebellum atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17759 Striatum atrophy thalamus atrophy status StrAtrophyThalamusAtrophyStat Status of atrophy in the thalamus. Status of atrophy in the thalamus. Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C18153 Data unknown text DataUnknwnTxt The free-text field to Mark an "X" in to record if data are unknown or not available. The free-text field to Mark an "X" in to record if data are unknown or not available. Or data. CAG repeat HD-IT 15 CAG repeat expansion unknown Alphanumeric

If the size of the HD-IT 15 CAG expansion is unknown, record as Not Known in the next data element.

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C15057 Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites status BrAtSubNigraLeBodyLeNeurStat Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. Lewy body containing neurons (LBCN) and Lewy neurites (LN) Absent;Present Absent;Present Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C08177 Hemorrhage indicator HemrrhgInd Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Are there single or multiple hemorrhages? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C14976 Brain atrophy surface severity result BrainAtrophySurfSevReslt Quantitative result of the severity of cerebral atrophy on external brain surface Quantitative result of the severity of cerebral atrophy on external brain surface Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if "Present" is answered for "On gross examination of the external surface of the brain, cerebral atrophy". This question is answered for each of the brain anatomic sites.

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Single Pre-Defined Value Selected

C15100 Cortical laminar necrosis single or multiple text CortLaminarNecSingMultiTxt The text description of the cortical laminar necrosis The text description of the cortical laminar necrosis Describe Alphanumeric

Answer for each vascular territory and event category

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C15036 Brain atrophy neuronal loss and fibrillary astrocytosis pontes griseum or gray matter caudo-lenticular bridges anatomic site BrAtNeLosFibAstroPonAntmicSite Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Pontes griseum or gray matter caudo-lenticular bridges Dorsal half;Ventral half Dorsal half;Ventral half Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08149 Diagnosis final clinical death type DiagnosFinalClinDeathTyp Physician's final clinical diagnosis for the participant/subject Physician's final clinical diagnosis for the participant/subject FINAL CLINICAL DIAGNOSIS BEFORE DETAH Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Alphanumeric

No additional instructions

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Multiple Pre-Defined Values Selected

C15068 Brain atrophy pontine nuclei globosum neuronal tangles (GNT) severity result BrAtPontNucGloNeurTanSevReslt Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei. Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

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Single Pre-Defined Value Selected

C15079 Brain atrophy cerebellum cortical neuronal loss in bergman gliosis status BrAtCerebCortNeurLosBerGliStat Status of cortical neuronal loss in the Bergman gliosis (BG) of the cerebellum Status of cortical neuronal loss in the Bergman gliosis (BG) of the cerebellum Bergman gliosis Absent;Present Absent;Present Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14987 Brain atrophy striatum body of caudate nucleus (CN) severity result BrAtStrCauNucBodySevReslt Quantitative result of the severity of atrophy located in the body of the caudate nucleus (CN) (at the coronal section passing through the lateral geniculate body). Quantitative result of the severity of atrophy located in the body of the caudate nucleus (CN) (at the coronal section passing through the lateral geniculate body). Body of the CN Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: At the coronal section passing through the lateral geniculate body: atrophy

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Single Pre-Defined Value Selected

C15111 Arteriosclerosis severity score ArteriosclerosisSevScore Severity score for arteriosclerosis (small parenchymal arteriolar disease) Severity score for arteriosclerosis (small parenchymal arteriolar disease) Yes Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered only if "Yes" is answered for "Is there arteriosclerosis (small parenchymal arteriolar disease)?"

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Single Pre-Defined Value Selected

C15047 Brain atrophy subthalamic nucleus neuronal loss indicator BrAtSubthalNucNeurLossInd Indicator of neuronal loss in the subthalamic nucleus. Indicator of neuronal loss in the subthalamic nucleus. Subthalamic nucleus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08163 CERAD neuropathological criteria scale CERADNeuropathCritScale CERAD neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease CERAD neuropathological criteria (e.g., neuritic plaques) Alzheimer disease (AD) Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08179 Cortical laminar necrosis indicator CortclLamnrNecrsisInd Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries Is there cortical laminar necrosis? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15090 Cortical infarcts single or multiple vascular territories name CorInfarcSingMultiVasclTeName Name of the vascular territories where cortical microinfarcts occur Name of the vascular territories where cortical microinfarcts occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15026 Brain atrophy cerebellum severity result BrAtCerebellumSevReslt Quantitative result of the severity of cerebellum atrophy located in the striatum. Quantitative result of the severity of cerebellum atrophy located in the striatum. Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

This question is answered if 'Present' is answered for 'Cerebellum atrophy'

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Single Pre-Defined Value Selected

C17760 Striatum atrophy thalamus atrophy severity result StrAtrophyThalAtrophySevReslt Quantitative result of the severity of atrophy located in the thalamus. Quantitative result of the severity of atrophy located in the thalamus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C18667 Data source other text DataSourcOTH The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form Other, specify Alphanumeric

No additional instructions

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C15058 Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites severity result BrAtSubNigraLeCBodLeNeSevReslt Quantitative result of the severity of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra. Quantitative result of the severity of Lewy-body containing neurons (LBCN) and Lewy neurites (LN) in the substantia nigra. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C14977 Brain atrophy coronal sections cerebral cortex status BrainAtrophyCorSecCerCortStat Status of cerebral cortex atrophy of the coronal sections upon gross examination Status of cerebral cortex atrophy of the coronal sections upon gross examination Cerebral cortex atrophy Absent;Present Absent;Present Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C15101 Atherosclerotic vascular pathology indicator AtheroscleroticVasclPathInd Indicator of atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis) Indicator of atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis) Are there atherosclerotic, either non-stentoic or stentoic vascular changes? None;Yes non-stenotic;Yes stenotic;Not assessed;Not available None;Yes non-stenotic;Yes stenotic;Not assessed;Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15037 Brain atrophy neuronal loss and fibrillary astrocytosis putamen anatomic site BrAtNeLosFibAstroPutAntmicSite Anatomic site in the putamen where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the putamen where neuronal loss and/or fibrillary astrocytosis is/are present Putamen Rostral, dorsal half;Rostral, ventral half;Nucleus accumbens Rostral, dorsal half;Rostral, ventral half;Nucleus accumbens Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08151 Diagnosis final clinical death date DiagnosFinalClinDeathDate Date of participant's/subject's final clinical diagnosis Date of participant's/subject's final clinical diagnosis Date of final clinical diagnosis Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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C15069 Brain atrophy medulla oblongata dorsal nucleus vagus reticular formation status BrAtMedObDorsNucVagRetFormStat Status of dorsal nucleus of vagus reticular formation: Lewy body containing neurons (LBCN) and Lewy neurites (LN) in the medulla oblongata. Status of dorsal nucleus of vagus reticular formation: Lewy body containing neurons (LBCN) and Lewy neurites (LN) in the medulla oblongata. Dorsal nucleus of vagus - reticular formation Lewy body-containing neurons (LBCN) and Lewy neurites (LN) Absent;Present Absent;Present Alphanumeric

Medulla oblongata

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Single Pre-Defined Value Selected

C15080 Brain atrophy cerebellum myelin loss in cerebellar white matter indicator BrAtCerebMyeLossCerWMInd Indicator of myelin loss in the cerebellar white matter of the cerebellum Indicator of myelin loss in the cerebellar white matter of the cerebellum Cerebellar white matter Myelin loss No myelin loss;Yes myelin loss No myelin loss;Yes myelin loss Alphanumeric

Cerebellum; Cerebellar white matter: Myelin loss

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Single Pre-Defined Value Selected

C14988 Brain atrophy striatum putamen severity result BrAtStPutSevReslt Quantitative result of the severity of atrophy located in the putamen. Quantitative result of the severity of atrophy located in the putamen. Putamen Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: Atrophy

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Single Pre-Defined Value Selected

C17398 Specimen other postmortem text SpecOthPostmortText Text area to describe other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Description of other available banked postmortem specimens Yes (Describe) Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2012-12-20 00:00:00.0 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C15048 Brain atrophy subthalamic nucleus neuronal loss severity result BrAtSubthalNucNeurLossSevReslt Quantitative result of the severity of neuronal loss in the subthalamic nucleus Quantitative result of the severity of neuronal loss in the subthalamic nucleus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered if "Yes, neuronal loss" is answered for 'Subthalamic nucleus: neuronal loss"

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Single Pre-Defined Value Selected

C08166 Brain atrophy Braak and Braak neurofibrillary stage BrAtBraakBraakNeurofibStage Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. If yes, select Braak stage Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI Alphanumeric

This question is answered only if Present is answered for "Braak and Braak Neurofibrillary Tanlge Stage"

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Single Pre-Defined Value Selected

C08181 Other pathology ischemic vascular disease indicator OthrPathlgyIschmcVasclrDisInd Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Are there other vascular-depending changes, which are not previously specified? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

If yes, specify other

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Single Pre-Defined Value Selected

C15091 Cortical infarcts single or multiple description text CorInfarcSingMultiDescriptTxt The text description of the cortical microinfarcts The text description of the cortical microinfarcts Describe Alphanumeric

Answer for each vascular territory and event category

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C15027 Brain atrophy cortex neuronal loss indicator BrAtCerebralCortexNeurLossInd Indicator of neuronal loss in the cerebral cortex Indicator of neuronal loss in the cerebral cortex Cerebral cortex Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17761 Striatum atrophy subthalamic nucleus atrophy status StrAtrophySubthalNuAtrophyStat Status of atrophy in the subthalamic nucleus. Status of atrophy in the subthalamic nucleus. Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C18669 Diagnosis final clinical death other text DiagnosFinalClinDeathOTH The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject Other, specify Alphanumeric

No additional instructions

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C15059 Brain atrophy nucleus coeruleus neuronal loss indicator BrAtNucCoerNeurLossInd Indicator of neuronal loss in the nucleus coeruleus. Indicator of neuronal loss in the nucleus coeruleus. Nucleus coeruleus No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Nucleus coeruleus

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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C14978 Brain atrophy coronal sections cerebral cortex severity result BrainAtCorSecCereCorSevReslt Quantitative result of the severity of cerebral cortex atrophy in the coronal sections of the brain Quantitative result of the severity of cerebral cortex atrophy in the coronal sections of the brain Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

Coronal slices: On gross examination of the coronal sections

No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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C15102 Arteriosclerosis indicator ArteriosclerosisInd Indicator of arteriosclerosis (small parenchymal arteriolar disease) Indicator of arteriosclerosis (small parenchymal arteriolar disease) Is there arteriosclerosis (small parenchymal arteriolar disease)? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

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No references available Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

CSV