CDE Detailed Report

Disease: Huntington's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 1 - 50 of 175
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C14971 Macroscopical examination fresh brain source MacroExamFreshBrainSource The part(s) of the fresh brain used for macroscopical examination The part(s) of the fresh brain used for macroscopical examination Macroscopical examination Fresh Whole brain;Left half brain;Right half brain;Not available;Other specify Whole brain;Left half brain;Right half brain;Not available;Other specify Alphanumeric

Indicate the parts selected for evaluation

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Single Pre-Defined Value Selected

C15095 Hemorrhages single or multiple event category HemorrhageSingMultiEvntCat Category of the hemorrhages Category of the hemorrhages Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15031 Brain atrophy hippocampal formation neuronal loss indicator BrAtHippocampFormNeurLossInd Indicator of neuronal loss in the hippocampal formation. Indicator of neuronal loss in the hippocampal formation. Hippocampal formation Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C02411 Laterality type LatTyp Laterality type relative to the anatomic site of the body examined or affected Laterality type relative to the anatomic site of the body examined or affected Bilateral;Left;Right;Unknown Bilateral;Left;Right;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18994 Microscopical examination blocks other text MicroExamBlocksOTH The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain Other, specify Alphanumeric

Indicate the parts selected for evaluation

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C15063 Brain atrophy nucleus coeruleus globosum neuronal tangles status BrAtNucCoerGloNeurTanglesStat Status of globosum neuronal tangles (GNT) in the nucleus coeruleus. Status of globosum neuronal tangles (GNT) in the nucleus coeruleus. Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Nucleus coeruleus

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C15074 Brain atrophy cerebellum cortical neuronal loss in associative layer severity result BrAtCerCortNeurLosAsocSevReslt Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14982 Brain atrophy coronal sections hippocampal formation severity result BrAtCorSecHippFormSevReslt Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15106 Clinicopathology diagnosis final type ClinicopathDiagnosFinalTyp The participant/subject's final clinicopathological diagnosis The participant/subject's final clinicopathological diagnosis Yes Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Alphanumeric

No additional instructions

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C15042 Brain atrophy fibrillary astrocytosis severity result BrAtFibAstroSevReslt Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Yes, neuronal loss 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

Answer for caudate nucleus, pontes griseum or gray matter caudo-lenticular bridges, putamen, and globus pallidus anatomic sites.

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Single Pre-Defined Value Selected

C08156 Specimen other postmortem indicator SpecmnOtherPstmortemInd Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Are other banked postmortem specimens available? (e.g. blood, spinal cord, nerve, muscle) Yes;No Yes;No Alphanumeric

If YES is answered then explain what other type(s) of postmortem samples exist

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C15085 Silver staining methods type SilverStainMethdsTyp Silver staining methods used for identifying Alzheimer disease type changes Silver staining methods used for identifying Alzheimer disease type changes Silver methods Bielschowsky;Other, specify;Not assessed;Missing/Unknown Bielschowsky;Other, specify;Not assessed;Missing/Unknown Alphanumeric

Answer for each type of microscopic brain abnormality

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C15021 Brain atrophy substantia nigra appearance grade BrAtSubstantiaNigraAppGrade Grade of pigmentation of the substantia nigra Grade of pigmentation of the substantia nigra Substantia nigra Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Alphanumeric

Striatum atrophy

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C17755 Striatum atrophy claustrum atrophy status StrAtrophyClaustrumAtrophyStat Status of atrophy in the claustrum. Status of atrophy in the claustrum. Claustrum atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C17764 Striatum atrophy red nucleus atrophy severity result StrAtrophyRedNuAtrophySevReslt Quantitative result of the severity of atrophy located in the red nucleus. Quantitative result of the severity of atrophy located in the red nucleus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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C15053 Brain atrophy substantia nigra pars compacta neuronal loss indicator BrAtSubNigraParsCompNeurLosInd Indicator of neuronal loss in the pars compacta of the substantia nigra. Indicator of neuronal loss in the pars compacta of the substantia nigra. Pars compacta Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

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C08171 Diffuse plaques density category DiffusePlaqDenstyCat Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Immatue and diffuse type plaques (are plaques without the dense core of the neuritic plaques and are either with [immature] or without [diffuse] dystrophic neurites) No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown Alphanumeric

Amyloid plaques

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C14972 Macroscopical examination fixed brain source MacroExamFixedBrainSource The part(s) of the fixed brain used for macroscopical examination The part(s) of the fixed brain used for macroscopical examination Macroscopical examination Fixed Whole brain;Left half brain;Right half brain;Not available;Other, specify Whole brain;Left half brain;Right half brain;Not available;Other, specify Alphanumeric

Indicate the parts selected for evaluation

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C15096 Hemorrhages single or multiple vascular territories name HemSingMultiVascTerrName Name of the vascular territories where hemorrhages occur Name of the vascular territories where hemorrhages occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15032 Brain atrophy hippocampal formation neuronal loss severity result BrAtHippocFormNeurLossSevReslt Quantitative result of the severity of neuronal loss in the hippocampal formation Quantitative result of the severity of neuronal loss in the hippocampal formation Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Hippocampal formation neuronal loss'

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C04802 Death date and time DeathDateTime Date (and time, if known) of participant's/subject's death Date (and time, if known) of participant's/subject's death Date of Death; Time of Death Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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2004152
C18995 Brain atrophy thalamus neuronal loss nuclei other text BrAtThalamusNeurLossNucOTH The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss Other, specify Alphanumeric

No additional instructions

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C15064 Brain atrophy nucleus coeruleus globosum neuronal tangles (GNT) severity result BrAtNucCoerGloNeurTanSevReslt Quantitative result of the severity of GNT in the nucleus coeruleus. Quantitative result of the severity of GNT in the nucleus coeruleus. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Nucleus coeruleus

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C15075 Brain atrophy cerebellum cortical neuronal loss in receptive layer indicator BrAtCerebCortNeurLossRecLayInd Indicator of cortical neuronal loss in the receptive layer (granular) of the cerebellum Indicator of cortical neuronal loss in the receptive layer (granular) of the cerebellum Receptive layer (granular) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

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C14983 Brain atrophy coronal sections amygdala status BrAtCorSecAmygdalaStat Status of amygdala atrophy of the coronal sections upon gross examination. Status of amygdala atrophy of the coronal sections upon gross examination. Amygdala atrophy Absent;Present Absent;Present Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15107 Huntingtons Disease diagnosis grade HDDiagnosGrade The grade of severity of HD or amyloid angiopathy severity The grade of severity of HD or amyloid angiopathy severity Final Clinicopathological Diagnosis Grade 1;Grade 2;Grade 3;Grade 4 Grade 1;Grade 2;Grade 3;Grade 4 Alphanumeric

Only answered if "Huntington disease" or "Cerebral amyloid angiopathy" are answered for Final Clinicopathological diagnoses

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C15043 Brain atrophy thalamus neuronal loss indicator BrAtThalamusNeurLossInd Indicator of neuronal loss in the thalamus. Indicator of neuronal loss in the thalamus. Thalamus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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C08157 Photograph macroscopic indicator PhotographsMacroscopicInd Indicator of whether macroscopic photographs were taken Indicator of whether macroscopic photographs were taken Are macroscopic photographs available? Yes;No Yes;No Alphanumeric

If YES is answered explain what macroscopic photographs were taken

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C08173 Ischemic hemorrhagic or vascular pathology indicator IschHemVasclPathInd Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Are there ischemic or hemorrhagic changes? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If 'No' is answered for ischemic or hemorrhagic changes, skip to question 43.

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C15086 Ischemic or hemorrhagic changes event category IschHemChangesEventCat Category of the ischemic or hemorrhagic changes Category of the ischemic or hemorrhagic changes Yes, present Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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C15022 Brain atrophy nucleus coeruleus appearance grade BrAtNucleusCoeruleusAppGrade Grade of pigmentation of the nucleus coeruleus Grade of pigmentation of the nucleus coeruleus Nucleus coeruleus Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Alphanumeric

Striatum atrophy

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C17756 Striatum atrophy claustrum atrophy severity result StrAtrophyClauAtrophySevReslt Quantitative result of the severity of atrophy located in the claustrum. Quantitative result of the severity of atrophy located in the claustrum. Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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C17765 Striatum atrophy hydrocephalus lateral ventricle severity result StrAtrophyHydroLatVentSevReslt Quantitative result of the severity of hydrocephalus located in the lateral ventricle. Quantitative result of the severity of hydrocephalus located in the lateral ventricle. Lateral ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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C15054 Brain atrophy substantia nirgra pars compacta neuronal loss severity result BrAtSubNiParsCoNeuLossSevReslt Quantitative result of the severity of neuronal loss in the pars compacta. Quantitative result of the severity of neuronal loss in the pars compacta. Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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C14973 Microscopical examination blocks source MicroExamBlocksSource The source of blockage based on microscopical examination of brain The source of blockage based on microscopical examination of brain Microscopical examination Source of blocks Not available;Other, specify;Bilateral;Left half of brain;Right half of brain Not available;Other, specify;Bilateral;Left half of brain;Right half of brain Alphanumeric

Indicate the parts selected for evaluation

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C15097 Single or multiple hemorrhages description text SingMultiHemDescriptTxt The text description of the hemorrhages The text description of the hemorrhages Describe Alphanumeric

Answer for each vascular territory and event category

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C15033 Brain atrophy amygdala neuronal loss indicator BrAtAmygdalaNeurLossInd Indicator of neuronal loss in the amygdala. Indicator of neuronal loss in the amygdala. Amygdala Neuronal Loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date form completed Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

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C18996 Silver staining methods other text SilverStainMethdsOTH The free-text field related to 'Silver staining methods type' specifying other text. Silver staining methods used for identifying Alzheimer disease type changes The free-text field related to 'Silver staining methods type' specifying other text. Silver staining methods used for identifying Alzheimer disease type changes Other, specify Alphanumeric

Answer for each type of microscopic brain abnormality

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C15065 Brain atrophy pons neuronal loss indicator BrAtPonsNeurLossInd Indicator of neuronal loss in the pons. Indicator of neuronal loss in the pons. Pons Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Pons: Neuronal loss

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C15076 Brain atrophy cerebellum cortical neuronal loss in receptive layer severity result BrAtCerCortNeuLosRecLaSevReslt Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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C14984 Brain atrophy coronal sections amygdala severity result BrAtCorSecAmygdalaSevReslt Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15108 Diagnoses final clinicopathological severity scale DiagnosFinClinicopathSevScale Scale of the severity or intensity of the diagnosis Scale of the severity or intensity of the diagnosis Final Clinicopathological Diagnosis Mild;Moderate;Severe Mild;Moderate;Severe Alphanumeric

Only answered if "Encephalopathy of hypoxic-ischemic type, acute", "Alzheimer changes", or "Status cribrosus and lacunaris" are answered for Final Clinicopathological diagnoses

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C15044 Brain atrophy thalamus neuronal loss severity result BrAtThalamusNeurLossSevReslt Quantitative result of the severity of neuronal loss in the thalamus Quantitative result of the severity of neuronal loss in the thalamus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered if "Yes, neuronal loss" is answered for 'Thalamus: neuronal loss"

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C08158 Brain weight measurement BrainWgtMeasr Weight of the participant's/subject's brain in grams Weight of the participant's/subject's brain in grams Brain weight-Part weighed Numeric Values

This value should be recorded in grams (g) for all brain tissue weighed

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gram
C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are there single or multiple cortical microinfarcts (each, <1.5cm in greatest dimension, including "granular atrophy")? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Cortical microinfarcts are defined as

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C15087 Ischemic or hemorrhagic vascular territories name IschHemVasclTerritoriesName Name of the vascular territories where ischemic or hemorrhagic changes occur Name of the vascular territories where ischemic or hemorrhagic changes occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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C15023 Brain atrophy striatum brainstem status BrAtStriatumBrainstemStat Status of brainstem atrophy in the striatum. Status of brainstem atrophy in the striatum. Brainstem atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

Kemper TL. Neuroanatomical and Neuropathological changes during aging and dementia, Second edn., Oxford University Press, New York, 1994, 3-67. Esiri MM and Morris JH. Practical approach to pathological diagnosis. In: Esiri MM, Lee VM-Y, Trojanowski JQ, eds. The neuropathology of dementia. First ed. Cambridge CB2 2RU, UK: Cambridge University Press; 2004:48-74. Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

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C17757 Striatum atrophy hypothalamus atrophy status StrAtrophyHypothAtrophyStat Status of atrophy in the hypothalamus. Status of atrophy in the hypothalamus. Hypothalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C17766 Striatum atrophy hydrocephalus third ventricle severity result StrAtrophyHydroThVentSevReslt Quantitative result of the severity of hydrocephalus located in the third ventricle. Quantitative result of the severity of hydrocephalus located in the third ventricle. Third ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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Single Pre-Defined Value Selected

CSV