CDE Detailed Report

Disease: Stroke
Sub-Domain: Classification
CRF: Stroke Types and Subtypes

Displaying 1 - 50 of 88
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C58901 Causative Classification System (CCS) - small artery occlusion phenotype status CCSSmlArtOcclsnPhntypStat The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of small artery occlusion. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult;Pediatric Supplemental 1.00 2020-05-19 13:04:42.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58915 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy secondary diagnosis subtype classification status VIPSArtpthyScdyDgnSbtypClsStat The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. If definite arteriopathy, indicate secondary diagnosis Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:40:29.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58902 Causative Classification System (CCS) - other uncommon cause phenotype status CCSOthrUncmnCausePhntypStat The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of other uncommon causes. Major;Absent Major;Absent Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult;Pediatric Supplemental 1.00 2020-05-19 13:34:35.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58916 Vascular effects of Infection in Pediatric Stroke (VIPS) - focal cerebral arteriopathy type VIPSFCATyp Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Focal cerebral arteriopathy (FCA) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 11:00:31.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58904 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - atherothrombosis grade ASCODSystemAtherothrGrade The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). Evaluate the patients for the predefined phenotype of atherosclerosis (A). 0;1;2;3;9 Atherosclerosis not detected. Ruling out atherosclerosis: (1) extracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-Duplex,CTA, MRA, XRA, or autopsy, (2) intracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-TCD,MRA, CTA, XRA, or autopsy, (3) aortic arch atheroma: TEE with specific assessment of the aortic arch (when the probe is pulled back at the end of the cardiac examination, turn the probe counter clockwise and take time to watch the aortic arch) or specific aortic arch assessment with CTA;Potentially causal. Atherothrombotic stroke defined as: (1) ipsilateral atherosclerotic stenosis between 50 and 99% in an intra- or extracranial artery supplying the ischemic field, or (2) ipsilateral atherosclerotic stenosis;Causal link is uncertain. (1) ipsilateral atherosclerotic stenosis 30–50% in an intra- or extracranial artery supplying the ischemic field, or (2) aortic plaque =4 mm without mobile lesion;Causal link is unlikely, but the disease is present. (1) plaque (stenosis <30%) in an intra- or extracranial artery, ipsilateral to the infarct area, (2) aortic plaque <4 mm without mobile thrombus, (3) stenosis (any degree) or occlusion in a cerebral artery not supplying the infarct area (e.g. contralateral side or opposite circulation), (4) history of myocardial infarction, coronary revascularization or peripheral arterial disease, (5) ipsi- or bilateral atherosclerotic stenosis 50–99% with bihemispheric MR-DWI lesion;Incomplete workup. US-Duplex, US-TCD or CTA, or MRA, or XRA or autopsy not performed. [A minimum workup is extra- and intracranial assessment of cerebral arteries – maximum workup also includes transesophageal assessment of the aortic arch (or a default CTA of the aortic arch)] Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-19 13:41:48.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58917 Focal Cerebral Arteriopathy Severity Score (FCASS) - supraclinoid internal carotid artery score scale FCASSSupraclinoidICAScoreScl The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score supraclinoid ICA 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:11:28.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58676 Birth sex assigned type BirthSexAssignTyp Self-reported phenotypic sex of participant/subject, assigned at birth. Self-reported phenotypic sex of participant/subject, assigned at birth. Sex assigned at birth Male;Female;Intersex;Unknown;Other, specify Male;Female;Intersex;Unknown;Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Core 1.00 2020-01-07 14:00:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58907 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - small vessel grade ASCODSystemSmallVesselGrade The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). Evaluate the patients for the predefined phenotype of small vessel disease (S). 0;1;2;3;9 Small-vessel disease not detected. Ruling out small-vessel disease stroke: negative MRI (T2, FLAIR, GRE, DWI) and no appropriate clinical syndrome suggestive of a deep branch artery stroke;Potentially causal. Combination of: (1) lacunar infarction: small deep infarct <15 mm (in perforator branch territory) on MRI-DWI (or a default CT) in an area corresponding to the symptoms and at least one of the three following criteria: (2) one or several small deep older infarct(s) of lacunar type in other territories, and/or (3) severe (confluent – Fazekas III) leukoaraiosis, or microbleeds, or severe dilatation of perivascular spaces ('État criblÉ'), (4) repeated, recent (<1 month), TIAs attributable to the same territory as the index infarct;Causal link is uncertain. (1) only one, recent, lacunar infarction and no other abnormality on MRI (or CT) or (2) clinical syndrome suggestive of a deep branch artery stroke, without ischemic lesion in the appropriate area seen on MRI or CT (main clinical syndrome suggesting a deep branch artery – lacunar – stroke: pure hemiparesis, pure hemisensory loss, ataxic hemiparesis, dysarthria-clumsy hand syndrome, unilateral sensorimotor deficit, others: hemichorea, hemiballism, pure dysarthria, etc.);Causal link is unlikely, but the disease is present. Severe (confluent – Fazekas III) leukoaraiosis visible on MRI and/or CT scan, and/or microbleeds visible on T2*-weighted MRI, and/or severe dilatation of perivascular spaces (visible on T2-weighted MRI), and/or one or several old, small deep infarcts of lacunar type;Incomplete workup. MRI (or CT) not performed Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-20 07:50:40.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58918 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 1 segment score scale FCASSMidCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:28:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58780 Birth sex assigned type other text BirthSexAssignTypOthrTxt The free-text field related to "Birth sex assigned type" specifying other text. The free-text field related to "Birth sex assigned type" specifying other text. Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-12 10:47:54.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58908 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - cardioembolic grade ASCODSystemCardioembGrade The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). Evaluate the patients for the predefined phenotype of cardiac pathology (C). 0;1;2;3;9 Cardiac pathology not detected or not suspected. Ruling out a cardiac source of embolism: minimum is negative ECG and examination by a cardiologist, maximum is negative ECG/telemetry/24-hour Holter ECG/long-term ECG recording (implantable device, transtelephonic ECG, loop recorder) and negative TEE for atrium, valves and septal abnormalities, negative TTE for PFO and assessment of left ventricle, negative cardiac CT/MRI, negative abdominal CT/MRI (search for old or simultaneous subdiaphragmatic visceral infarction);Potentially causal. Cardiogenic stroke defined as acute, or recent and older bihemispheric or supra- and infratentorial territorial or cortical ischemic lesions and signs of systemic embolism with detection of at least one of the following potential causes: (1) mitral stenosis (surface <1.5 cm 2 ), (2) mechanical valve, (3) myocardial infarction within 4 weeks preceding the cerebral infarction, (4) mural thrombus in the left cavities, (5) aneurysm of the left ventricle, (6) history or presence of documented atrial fibrillation – whether paroxysmal (>60 s), persistent or permanent – or flutter, with or without left atrial thrombus or spontaneous echo, (7)atrial disease (tachycardia-bradycardia syndrome), (8) dilated or hypertrophic cardiomyopathies, (9) left ventricle ejection fraction <35%, (10) endocarditis, (11) intracardiac mass, (12) PFO and thrombus in situ, (13) PFO and concomitant pulmonary embolism or proximal DVT preceding the index cerebral infarction, (14) aforementioned cardiac pathologies (C1) with single or without obvious cerebral ischemic lesion;Causal link is uncertain. Regardless of stroke pattern: (1) PFO + atrial septal aneurysm, (2) PFO and pulmonary embolism or proximal DTV concomitant but NOT preceding the index cerebral infarction, (3) intracardiac spontaneous echo-contrast, (4) apical akinesia of the left ventricle and decreased ejection fraction (but >35%), (5) history of myocardial infarction or palpitation and multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation), (6) no direct cardiac source identified, but multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation) and/or evidence of systemic emboli: renal or splenic or mesenteric infarction (on CT, MRI or autopsy) or embolism in peripheral artery supplying arm or leg;Causal link is unlikely, but the disease is present. One of the following abnormalities present in isolation: PFO, ASA, strands, mitral annulus calcification, calcification aortic valve, nonapical akinesia of the left ventricle, transient atrial fibrillation;Incomplete workup. Minimum is ECG and examination by a trained cardiologist in the absence of cardiac imaging. Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-20 08:40:20.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58919 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 1 segment score scale FCASSAntCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:32:41.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58893 Clinical stroke time based ischemic stroke laterality type ClnStrokeTimBaseIschmSrkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 09:56:46.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58909 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - other grade ASCODSystemOtherGrade The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). Evaluate the patients for the predefined phenotype of other cause (O). 0;1;2;3;9 No other cause detected. Ruling out other causes: negative: cerebrospinal fluid, complete hemostasis, cerebral arterial imaging, family history of inherited disease, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein), hematologic tests (platelet, leucocytes, and eosinophilic counts, hematocrit), specific tests according to the suspected disease (e.g. genetic test, retinal angiography for Susac syndrome);Potentially causal. (1) dolichoectasia with complicated aneurysm, (2) polycythemia vera or thrombocytemia >800,000/mm3, (3) systemic lupus, (4) disseminated intravascular coagulation, (5) antiphospholipid antibody syndrome (including >100 GPL units or lupus anticoagulant), (6) Fabry's disease, (7) coexisting meningitis, (8) sickle cell disease, (9) ruptured intracranial aneurysm with or without vasospasm of the artery supplying the infarcted area, (10) severe hyperhomocysteinemia, (11) Horton's disease, (12) other cerebral inflammatory or infectious angiitis, (13) moyamoya disease, etc.;Causal link is uncertain. (1) saccular aneurysm (with a suspicion of embolism from it), (2) coincidental migraine attack with neurological deficit lasting >60 min in patients with history of migraine aura;Causal link is unlikely but the disease is present. (1) arteriovenous malformation, (2) thrombocythosis <800,000/mm3, (3) antiphospholipid antibody <100 GPL units, (4) homocysteinemia <40 ?mol/l, (5) malignoma with associated hypercoagulation (high D-dimer levels), deep vein thrombosis or pulmonary embolism and/or recent chemotherapy;Incomplete workup. Unable to reasonably exclude other causes based on best available diagnostic tests and stroke-specific history Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-20 08:55:53.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58920 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 2 segment score scale FCASSMidCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:35:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58894 Clinical stroke time based Intracerebral hemorrhage laterality type ClinStrokeTimeBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:38:36.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58910 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - dissection grade ASCODSystemDissectionGrade The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). Evaluate the patients for the predefined phenotype of dissection (D) 0;1;2;3;9 No dissection detected or suspected. Ruling out dissection: negative FAT-saturated MRI of suspected artery or good quality, normal X-ray angiography (too early FAT-saturated MRI performed within 3 days of symptom onset can be falsely negative and then should be repeated). If there is no clinical suspicion of dissection, the patient can be classified D0 provided good-quality extra- or intracranial cerebral artery and cardiac evaluations have been performed;Potentially causal. (1) arterial dissection by direct demonstration (evidence of mural hematoma: hypersignal on FAT-saturated MRI or at autopsy or on TOF-MRA or CT on axial sections showing both enlargement of the arterial wall by the hematoma with narrowing of the lumen or on echography showing an hypoechoic arterial wall with narrowing of the lumen and sudden enlargement of the carotid or vertebral (V2) artery diameter, (2) arterial dissection by indirect demonstration or by less sensitive or less specific diagnostic test (only long arterial stenosis beyond the carotid bifurcation or in V2, V3 or V4 without demonstration of arterial wall hematoma: on X-ray angiography, and/or echography and/or CTA and/or MRA) or unequivocal US with recanalization during follow-up;Causal link is uncertain. (1) arterial dissection by weak evidence (suggestive clinical history, e.g. painful Horner's syndrome or past history of arterial dissection), (2) imaging evidence of fibromuscular dysplasia of a cerebral artery supplying the ischemic field;Causal link is unlikely but the disease is present. (1) kinking or dolichoectasia without complicated aneurysm or plicature, (2) fibromuscular dysplasia on arteries not supplying the ischemic field;Incomplete workup. In patients aged less than 60 years and with no evidence of A1, A2, S1, C1, or O1 category: no FAT-saturated MRI performed on the extra- or intracranial artery supplying the ischemic field or no X-ray angiography performed (all performed within 15 days of symptom onset) Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-20 09:14:18.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58921 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 2 segment score scale FCASSAntCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:42:10.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58895 Clinical stroke tissue based ischemic stroke laterality type ClnStrokeTisBaseIschmStkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:44:07.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58911 Atherosclerosis small vessel disease cardiac pathology other cause dissection (ASCOD) system - sub type ASCODSystemSubTyp Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Identify the Stroke Subtype as defined by the A-S-C-O-D pattern Alphanumeric

This element combines the 5 separate phenotype grades. It should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification. The format is A_S_C_O_D_; where blanks contain numbers 0, 1, 2, 3 or 9.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult;Pediatric Supplemental 1.00 2020-05-20 09:22:47.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58922 Focal Cerebral Arteriopathy Severity Score (FCASS) - baseline score FCASSBaselineScore Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Baseline score Numeric Values

Sum the five individual scores (without weighting); the maximum baseline score is 20 (maximum individual segment score of 4 multiplied by 5 arterial segments).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:44:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58896 Clinical stroke tissue based Intracerebral hemorrhage laterality type ClinStokeTissBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 12:17:39.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58912 Embolic stroke of undetermined source (ESUS) - criteria category ESUSCriteriaCat The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). Identify Embolic Stroke of Undetermined Source Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Alphanumeric

Select all that apply. Requires all items to be checked.

Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ; Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014;13(4):429-438 Adult;Pediatric Supplemental 1.00 2020-05-20 09:26:26.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C58923 Focal Cerebral Arteriopathy Severity Score (FCASS) - delta point score code FCASSDeltaPointScoreCode The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score Delta Point (only for Follow-up score) (+1);(-1) if interval worsening (progression) not otherwise captured by the follow-up FCASS;if interval improvement not otherwise captured by the follow-up FCAS Numeric Values

Only for Follow-up score

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:49:37.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58898 Causative Classification System (CCS) - large artery atherosclerosis phenotype status CCSLrgArtryAthrsclrsPhntypStat The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of large artery atherosclerosis. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult;Pediatric Supplemental 1.00 2020-05-19 12:41:08.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58913 Perinatal arterial ischemic stroke type PerinatalArtIschmcStrkTyp Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Perinatal arterial ischemic stroke (PAIS) Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Alphanumeric

Choose one per stroke event.

Raju TN, Nelson KB, Ferriero D, Lynch JK, NICHD-NINDS Perinatal Stroke Workshop Participants. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007;120(3):609-616. Kirton A, DeVeber G, Pontigon AM, MacGregor D, Shroff M. Presumed perinatal ischemic stroke: vascular classification predicts outcomes. Ann Neurol.2008;63(4):436-443. Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, DeBaun MR, deVeber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER; American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke. 2019;50(3):e51-e96. Pediatric Supplemental?Highly Recommended 1.00 2020-05-20 10:01:27.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58924 Focal Cerebral Arteriopathy Severity Score (FCASS) - follow up sum score FollowUpSumScore Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Follow-up score Numeric Values

For follow-up imaging, sum the five individual scores (without weighting) and apply the delta point if applicable. The maximum follow-up score is 21 (20 plus the delta point).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:54:59.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58899 Causative Classification System (CCS) - cardiac embolism phenotype status CCSCardiacEmbolismPhntypStat The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of cardiac embolism. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult;Pediatric Supplemental 1.00 2020-05-19 12:58:14.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58914 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy primary diagnosis subtype classification status VIPSArtpthyPrmyDgnSbtypClsStat The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Indicate the subtype based on the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. No arteriopathy;Possible arteriopathy;Definite arteriopathy An isolated arterial occlusion in the context of clinical history and/or parenchymal imaging that typifies cardioembolism;An isolated arterial occlusion that could be attributable to either cardioembolism or an in situ arterial abnormality;The imaging appearance of an in situ arterial abnormality (stenosis, irregularity, occlusion, banding, pseudoaneurysm, dissection flap) not attributable to an exogenous thrombus (e.g., cardioembolism) and not considered a normal developmental variant. Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:14:49.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58925 Sophia chance findings during routine imaging other text SophiaChncFindDurRoutImgOthTxt The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context. Chance findings during routine imaging, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 1.00 2020-05-20 12:03:24.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C02411 Laterality type LatTyp Laterality type relative to the anatomic site of the body examined or affected Laterality type relative to the anatomic site of the body examined or affected Specify laterality Bilateral;Left;Right;Unknown;Midline Bilateral;Left;Right;Unknown;Midline Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental?Highly Recommended 3.00 2013-08-28 16:08:00.453 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14252 Subarachnoid hemorrhage suprasellar cistern score SuarachHemSupraCisScore SAH Volume Scale (Hijdra) - Suprasellar cistern left score SAH Volume Scale (Hijdra) - Suprasellar cistern left score Suprasellar cistern left score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14224 Acute ischemic cerebrovascular syndrome (AICS) - stroke sub type AICSStrokeSubTyp Ischemic stroke subtype based on the acute Ischemic cerebrovascular syndrome (AICS) classification system. Ischemic stroke subtype based on the acute Ischemic cerebrovascular syndrome (AICS) classification system. Identify the ischemic stroke subtype based on the acute Ischemic cerebrovascular syndrome (AICS) classification system. Definite AICS;Probable AICS;Possible AICS;Not AICS Acute onset of neurologic dysfunction of any severity consistent with focal brain ischemia and imaging/laboratory confirmation.;Acute onset of neurologic dysfunction of any severity suggestive of focal brain ischemic syndrome but without imaging/laboratory confirmation of acute ischemic pathology (diagnostic studies were negative but insensitive for ischemic pathology of the given duration, severity and location). Imaging, laboratory, and clinical data studies do not suggest non-ischemic etiology: possible alternative etiologies are ruled out.;Acute neurologic dysfunction of any duration or severity possibly consistent with focal brain ischemia without imaging/laboratory confirmation of acute ischemic pathology (diagnostic studies were not performed or were negative and sensitive for ischemic pathology of the given duration, severity and location). Possible alternative etiologies are not ruled out. Symptoms may be non-focal or difficult to localize.;Not AICS Alphanumeric

Choose one.

Kidwell CS, Warach S. Acute ischemic cerebrovascular syndrome: diagnostic criteria. Stroke. 2003;34(12):2995-2998 Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14265 NIH Ischemic Perinatal Stroke (IPS) - sub type NIHIPSSubTyp Subtype based on the Ischemic Perinatal Stroke (IPS) Workshop sponsored by NIH in 2007 Subtype based on the Ischemic Perinatal Stroke (IPS) Workshop sponsored by NIH in 2007 Indicate the subtype based on the Ischemic Perinatal Stroke (IPS) Workshop sponsored by NIH in 2007. Fetal ischemic stroke;Neonatal ischemic stroke;Presumed perinatal ischemic Fetal ischemic stroke;Neonatal ischemic stroke;Presumed perinatal ischemic Alphanumeric

No instructions available

Raju TN, Nelson KB, Ferriero D, Lynch JK., NICHD-NINDS Perinatal Stroke Workshop Participants. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007;120(3):609-616. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14237 Intracerebral hemorrhage presumed cause type ICHPresumedCauseTyp Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowed. Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowed. Indicate the presumed cause(s) of the intracerebral hemorrhage (ICH). Hypertensive;Amyloid angiopathy;Cavernous hemangioma;Venous angioma;Aneurysm (if SAH and ICH – then classified as SAH);Anti-coagulant related ICH;Thrombolytic ICH (not hemorrhagic transformation of cerebral infarction);Tumor;Undetermined;Other, specify;Arteriovenous malformation Hypertensive ICH is defined as an ICH in the setting of known history of hypertension in a deep, cerebellar, or brainstem location without another defined structural cause.;ICH presumed secondary to amyloid angiopathy is suggested by lobar ICH without another defined cause in the setting of prior lobar ICH, old cortical microhemorrhages on MRI, imaging of amyloid by PET, or biopsy/surgical specimen consistent with amyloid angiopathy.;Cavernous hemangioma;Venous angioma;Aneurysm (if SAH and ICH – then classified as SAH);Anti-coagulant related ICH;Thrombolytic ICH (not hemorrhagic transformation of cerebral infarction);Tumor;Undetermined;Other, specify;Arteriovenous malformation Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C19076 Sophia signs symptoms presentation neurological signs other text SophiaSignSymPresNuroSgnOthTxt The free-text field related to 'Sophia signs and symptoms on presentation type' specifying other text. Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. The free-text field related to 'Sophia signs and symptoms on presentation type' specifying other text. Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context Other neurological signs, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date information collected Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 21:00:23.88 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

C14253 Subarachnoid hemorrhage ambient cistern score SubarachHemAmbCisScore SAH Volume Scale (Hijdra) - Ambient cistern left score SAH Volume Scale (Hijdra) - Ambient cistern left score Ambient cistern left score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14225 Trial of ORG 10172 in Acute Stroke Treatment (TOAST) - ischemic stroke sub type TOASTIschemStrokSubTyp Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System Identify the Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System. Large artery atherosclerosis;Cardioembolism;Stroke of other determined etiology;Stroke of undetermined etiology;Small artery occlusion Atherosclerotic lesion causing greater than 50% stenosis;Divided into high-risk and medium-risk sources based on their relative potential to cause stroke;Rare causes such as non-atherosclerotic vasculopathies, hematologic disorders, or hypercoagulable states;Including, a. Two or more causes, b. Negative evaluation (unknown), c. Incomplete evaluation;Lacunar syndrome with or without evidence of ischemic lesion less than 1.5 cm in diameter in the brain stem or subcortical white matter Alphanumeric

Choose one.

Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14266 Sophia vessel sub type SophiaVesselSubTyp Sophia classification of stroke subtype by vessel affected Sophia classification of stroke subtype by vessel affected Identify the Sophia classification of stroke subtype by vessel affected. Neonatal arterial ischemic stroke (AIS);Neonatal cerebral sinovenous thrombosis (CST);Hemorrhagic stroke Neonatal arterial ischemic stroke (AIS);Neonatal cerebral sinovenous thrombosis (CST);Hemorrhagic stroke Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14238 Intraventricular hemorrhage presumed cause type IVHPresumedCauseTyp Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowed. Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowed. Indicate the presumed cause(s) of the intraventricular hemorrhage (IVH). Hypertensive;Tumor;Anti-coagulant related IVH;Arteriovenous malformation;Other, specify (list);Undetermined Hypertensive ICH is defined as an IVH in the setting of known history of hypertension without another defined structural cause.;Tumor;Anti-coagulant related IVH;Arteriovenous malformation;Other, specify (list);Undetermined Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C19077 Sophia imaging stroke composite diagnosis method other text SophiaImgStrkCompDiaMthdOthTxt The free-text field related to 'Imaging stroke composite diagnosis method type' specifying other text. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. The free-text field related to 'Imaging stroke composite diagnosis method type' specifying other text. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context Other, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C13831 Graeb intraventricular hemorrhage (IVH) scale - right lateral ventricle score GraebIVHScaleRightLatVentScore Indicates Graeb IVH Scale - Right lateral ventricle score Indicates Graeb IVH Scale - Right lateral ventricle score Right lateral ventricle score 1;2;3;4 Trace amount of blood or mild bleeding;< Half of the ventricle filled with blood;> Half of the ventricle filled with blood;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14254 Subarachnoid hemorrhage quadrigeminal cistern score SubarachHemQuadCisScore SAH Volume Scale (Hijdra) - Quadrigeminal cistern score SAH Volume Scale (Hijdra) - Quadrigeminal cistern score Quadrigeminal cistern score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14226 Stroke causative classification standard sub type StrokCausClassStandSubTyp Ischemic Stroke Subtype based on The Causative Classification System's - standard causative subtypes Ischemic Stroke Subtype based on The Causative Classification System's - standard causative subtypes Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard causative subtypes. Large artery atherosclerosis;Cardio-aortic embolism;Small artery occlusion;Other uncommon causes;Undetermined causes Either occlusive, or stenotic (greater than or equal to 50% diameter reduction or <50% diameter reduction with plaque ulceration or thrombosis or plaque with <50% diameter reduction that is seated at the site of the origin of the penetrating artery supplying the region of an acute lacunar infarct) vascular disease judged to be due to atherosclerosis in the clinically-relevant extracranial or intracranial arteries;Cardiac sources of embolism are segregated into high- and low-risk categories with reference to an objective 2% primary stroke risk threshold;Imaging evidence of a single and clinically relevant acute infarction less than 20 mm in greatest diameter within the territory of basal or brainstem penetrating arteries in the absence of any focal pathology in the parent artery at the site of the origin of the penetrating artery (focal atheroma, parent vessel dissection, vasculitis, vasospasm, etc.);Specific disease processes not included in the first 3 categories that involve clinically-appropriate brain arteries, including, a. Unknown-cryptogenic embolism: Angiographic evidence of abrupt cut-off in an otherwise normal looking artery or subsequent complete recanalization of a previously occluded artery, b. Unknown: Other cryptogenic strokes that do not fulfill the criteria for cryptogenic embolism, c. Unclassified: Multiple competing etiologies, d. Incomplete evaluation: Failure to investigate for a relevant etiology in the absence of positive evidence;Undetermined causes Alphanumeric

Choose one (the most likely mechanism).

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /><br />Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /><br />Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14267 Sophia timing sub type SophiaTimeSubTyp Sophia classification of stroke subtype by timing of stroke Sophia classification of stroke subtype by timing of stroke Identify the Sophia classification of stroke subtype by timing of stroke. Fetal stroke;Neonatal stroke;Presumed fetal or neonatal stroke Fetal stroke;Neonatal stroke;Presumed fetal or neonatal stroke Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14244 Subarachnoid hemorrhage etiology type SAHEtiologyTyp Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowed. Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowed. Indicate the presumed cause(s) of the subarachnoid hemorrhage (SAH). Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C13832 Graeb intraventricular hemorrhage (IVH) scale - left lateral ventricle score GraebIVHScaleLeftLatVentScore Indicates Graeb IVH Scale - Left lateral ventricle score Indicates Graeb IVH Scale - Left lateral ventricle score Left lateral ventricle score 1;2;3;4 Trace amount of blood or mild bleeding;< Half of the ventricle filled with blood;> Half of the ventricle filled with blood;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14255 Subarachnoid hemorrhage volume total measurement SubarachHemVolTotalMeasr Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Numeric Values

The total amount of subarachnoid blood (sum score) is calculated by adding the 10 sub-scores. The range for the total is 0 - 30 (integers). This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 30 milliliter
C14228 Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) - standard sub type BWCYSSStandardSubTyp Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Identify the Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System. Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Alphanumeric

Choose all that apply, following the additional coding instructions. Two "Probable" diagnoses are allowed if criteria were met for two conditions of equal priority. [High priority diagnoses = Atherosclerotic vasculopathy, Non-atherosclerotic vasculopathy, Cardiac/transcardiac embolism, and Hematologic/other. Lower priority diagnoses = Vasculopathy of uncertain cause (lacunar), Migrainous, Oral contraceptive and exogenous estrogen use, Other drug related, and Indeterminate.] However, a lower priority diagnosis cannot be coded as probable when a higher priority probable or possible diagnosis is present; the lower priority diagnosis has to be assigned a possible label.

Johnson CJ, Kittner SJ, McCarter RJ, Sloan MA, Stern BJ, Buchholz D, Price TR. Interrater reliability of an etiologic classification of ischemic stroke. Stroke. 1995;26(1):46-51. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

CSV