CDE Detailed Report

Disease: Stroke
Sub-Domain: Classification
CRF: Stroke Types and Subtypes

Displaying 1 - 50 of 88
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C58676 Birth sex assigned type BirthSexAssignTyp Self-reported phenotypic sex of participant/subject, assigned at birth. Self-reported phenotypic sex of participant/subject, assigned at birth. Sex assigned at birth Male;Female;Intersex;Unknown;Other, specify Male;Female;Intersex;Unknown;Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Core 1.00 2020-01-07 14:00:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58907 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - small vessel grade ASCODSystemSmallVesselGrade The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). Evaluate the patients for the predefined phenotype of small vessel disease (S). 0;1;2;3;9 Small-vessel disease not detected. Ruling out small-vessel disease stroke: negative MRI (T2, FLAIR, GRE, DWI) and no appropriate clinical syndrome suggestive of a deep branch artery stroke;Potentially causal. Combination of: (1) lacunar infarction: small deep infarct <15 mm (in perforator branch territory) on MRI-DWI (or a default CT) in an area corresponding to the symptoms and at least one of the three following criteria: (2) one or several small deep older infarct(s) of lacunar type in other territories, and/or (3) severe (confluent – Fazekas III) leukoaraiosis, or microbleeds, or severe dilatation of perivascular spaces ('État criblÉ'), (4) repeated, recent (<1 month), TIAs attributable to the same territory as the index infarct;Causal link is uncertain. (1) only one, recent, lacunar infarction and no other abnormality on MRI (or CT) or (2) clinical syndrome suggestive of a deep branch artery stroke, without ischemic lesion in the appropriate area seen on MRI or CT (main clinical syndrome suggesting a deep branch artery – lacunar – stroke: pure hemiparesis, pure hemisensory loss, ataxic hemiparesis, dysarthria-clumsy hand syndrome, unilateral sensorimotor deficit, others: hemichorea, hemiballism, pure dysarthria, etc.);Causal link is unlikely, but the disease is present. Severe (confluent – Fazekas III) leukoaraiosis visible on MRI and/or CT scan, and/or microbleeds visible on T2*-weighted MRI, and/or severe dilatation of perivascular spaces (visible on T2-weighted MRI), and/or one or several old, small deep infarcts of lacunar type;Incomplete workup. MRI (or CT) not performed Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 07:50:40.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58918 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 1 segment score scale FCASSMidCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:28:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58780 Birth sex assigned type other text BirthSexAssignTypOTH The free-text field related to 'Birth sex assigned type', specifying other text. The free-text field related to 'Birth sex assigned type', specifying other text. Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-12 10:47:54.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C58908 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - cardioembolic grade ASCODSystemCardioembGrade The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). Evaluate the patients for the predefined phenotype of cardiac pathology (C). 0;1;2;3;9 Cardiac pathology not detected or not suspected. Ruling out a cardiac source of embolism: minimum is negative ECG and examination by a cardiologist, maximum is negative ECG/telemetry/24-hour Holter ECG/long-term ECG recording (implantable device, transtelephonic ECG, loop recorder) and negative TEE for atrium, valves and septal abnormalities, negative TTE for PFO and assessment of left ventricle, negative cardiac CT/MRI, negative abdominal CT/MRI (search for old or simultaneous subdiaphragmatic visceral infarction);Potentially causal. Cardiogenic stroke defined as acute, or recent and older bihemispheric or supra- and infratentorial territorial or cortical ischemic lesions and signs of systemic embolism with detection of at least one of the following potential causes: (1) mitral stenosis (surface <1.5 cm 2 ), (2) mechanical valve, (3) myocardial infarction within 4 weeks preceding the cerebral infarction, (4) mural thrombus in the left cavities, (5) aneurysm of the left ventricle, (6) history or presence of documented atrial fibrillation – whether paroxysmal (>60 s), persistent or permanent – or flutter, with or without left atrial thrombus or spontaneous echo, (7)atrial disease (tachycardia-bradycardia syndrome), (8) dilated or hypertrophic cardiomyopathies, (9) left ventricle ejection fraction <35%, (10) endocarditis, (11) intracardiac mass, (12) PFO and thrombus in situ, (13) PFO and concomitant pulmonary embolism or proximal DVT preceding the index cerebral infarction, (14) aforementioned cardiac pathologies (C1) with single or without obvious cerebral ischemic lesion;Causal link is uncertain. Regardless of stroke pattern: (1) PFO + atrial septal aneurysm, (2) PFO and pulmonary embolism or proximal DTV concomitant but NOT preceding the index cerebral infarction, (3) intracardiac spontaneous echo-contrast, (4) apical akinesia of the left ventricle and decreased ejection fraction (but >35%), (5) history of myocardial infarction or palpitation and multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation), (6) no direct cardiac source identified, but multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation) and/or evidence of systemic emboli: renal or splenic or mesenteric infarction (on CT, MRI or autopsy) or embolism in peripheral artery supplying arm or leg;Causal link is unlikely, but the disease is present. One of the following abnormalities present in isolation: PFO, ASA, strands, mitral annulus calcification, calcification aortic valve, nonapical akinesia of the left ventricle, transient atrial fibrillation;Incomplete workup. Minimum is ECG and examination by a trained cardiologist in the absence of cardiac imaging. Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 08:40:20.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58919 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 1 segment score scale FCASSAntCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:32:41.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58893 Clinical stroke time based ischemic stroke laterality type ClnStrokeTimBaseIschmSrkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 09:56:46.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58909 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - other grade ASCODSystemOtherGrade The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). Evaluate the patients for the predefined phenotype of other cause (O). 0;1;2;3;9 No other cause detected. Ruling out other causes: negative: cerebrospinal fluid, complete hemostasis, cerebral arterial imaging, family history of inherited disease, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein), hematologic tests (platelet, leucocytes, and eosinophilic counts, hematocrit), specific tests according to the suspected disease (e.g. genetic test, retinal angiography for Susac syndrome);Potentially causal. (1) dolichoectasia with complicated aneurysm, (2) polycythemia vera or thrombocytemia >800,000/mm3, (3) systemic lupus, (4) disseminated intravascular coagulation, (5) antiphospholipid antibody syndrome (including >100 GPL units or lupus anticoagulant), (6) Fabry's disease, (7) coexisting meningitis, (8) sickle cell disease, (9) ruptured intracranial aneurysm with or without vasospasm of the artery supplying the infarcted area, (10) severe hyperhomocysteinemia, (11) Horton's disease, (12) other cerebral inflammatory or infectious angiitis, (13) moyamoya disease, etc.;Causal link is uncertain. (1) saccular aneurysm (with a suspicion of embolism from it), (2) coincidental migraine attack with neurological deficit lasting >60 min in patients with history of migraine aura;Causal link is unlikely but the disease is present. (1) arteriovenous malformation, (2) thrombocythosis <800,000/mm3, (3) antiphospholipid antibody <100 GPL units, (4) homocysteinemia <40 ?mol/l, (5) malignoma with associated hypercoagulation (high D-dimer levels), deep vein thrombosis or pulmonary embolism and/or recent chemotherapy;Incomplete workup. Unable to reasonably exclude other causes based on best available diagnostic tests and stroke-specific history Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 08:55:53.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58920 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 2 segment score scale FCASSMidCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:35:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58894 Clinical stroke time based Intracerebral hemorrhage laterality type ClinStrokeTimeBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:38:36.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58910 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - dissection grade ASCODSystemDissectionGrade The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). Evaluate the patients for the predefined phenotype of dissection (D) 0;1;2;3;9 No dissection detected or suspected. Ruling out dissection: negative FAT-saturated MRI of suspected artery or good quality, normal X-ray angiography (too early FAT-saturated MRI performed within 3 days of symptom onset can be falsely negative and then should be repeated). If there is no clinical suspicion of dissection, the patient can be classified D0 provided good-quality extra- or intracranial cerebral artery and cardiac evaluations have been performed;Potentially causal. (1) arterial dissection by direct demonstration (evidence of mural hematoma: hypersignal on FAT-saturated MRI or at autopsy or on TOF-MRA or CT on axial sections showing both enlargement of the arterial wall by the hematoma with narrowing of the lumen or on echography showing an hypoechoic arterial wall with narrowing of the lumen and sudden enlargement of the carotid or vertebral (V2) artery diameter, (2) arterial dissection by indirect demonstration or by less sensitive or less specific diagnostic test (only long arterial stenosis beyond the carotid bifurcation or in V2, V3 or V4 without demonstration of arterial wall hematoma: on X-ray angiography, and/or echography and/or CTA and/or MRA) or unequivocal US with recanalization during follow-up;Causal link is uncertain. (1) arterial dissection by weak evidence (suggestive clinical history, e.g. painful Horner's syndrome or past history of arterial dissection), (2) imaging evidence of fibromuscular dysplasia of a cerebral artery supplying the ischemic field;Causal link is unlikely but the disease is present. (1) kinking or dolichoectasia without complicated aneurysm or plicature, (2) fibromuscular dysplasia on arteries not supplying the ischemic field;Incomplete workup. In patients aged less than 60 years and with no evidence of A1, A2, S1, C1, or O1 category: no FAT-saturated MRI performed on the extra- or intracranial artery supplying the ischemic field or no X-ray angiography performed (all performed within 15 days of symptom onset) Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 09:14:18.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58921 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 2 segment score scale FCASSAntCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:42:10.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58895 Clinical stroke tissue based ischemic stroke laterality type ClnStrokeTisBaseIschmStkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:44:07.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58911 Atherosclerosis small vessel disease cardiac pathology other cause dissection (ASCOD) system - sub type ASCODSystemSubTyp Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Identify the Stroke Subtype as defined by the A-S-C-O-D pattern Alphanumeric

This element combines the 5 separate phenotype grades. It should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification. The format is A_S_C_O_D_; where blanks contain numbers 0, 1, 2, 3 or 9.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 09:22:47.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58922 Focal Cerebral Arteriopathy Severity Score (FCASS) - baseline score FCASSBaselineScore Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Baseline score Numeric Values

Sum the five individual scores (without weighting); the maximum baseline score is 20 (maximum individual segment score of 4 multiplied by 5 arterial segments).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:44:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58896 Clinical stroke tissue based Intracerebral hemorrhage laterality type ClinStokeTissBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 12:17:39.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58912 Embolic stroke of undetermined source (ESUS) - criteria category ESUSCriteriaCat The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). Identify Embolic Stroke of Undetermined Source Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Alphanumeric

Select all that apply. Requires all items to be checked.

Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ; Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014;13(4):429-438 Adult Supplemental 1.00 2020-05-20 09:26:26.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C58923 Focal Cerebral Arteriopathy Severity Score (FCASS) - delta point score code FCASSDeltaPointScoreCode The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score Delta Point (only for Follow-up score) (+1);(-1) if interval worsening (progression) not otherwise captured by the follow-up FCASS;if interval improvement not otherwise captured by the follow-up FCAS Numeric Values

Only for Follow-up score

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:49:37.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58898 Causative Classification System (CCS) - large artery atherosclerosis phenotype status CCSLrgArtryAthrsclrsPhntypStat The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of large artery atherosclerosis. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 12:41:08.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58913 Perinatal arterial ischemic stroke type PerinatalArtIschmcStrkTyp Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Perinatal arterial ischemic stroke (PAIS) Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Alphanumeric

Choose one per stroke event.

Raju TN, Nelson KB, Ferriero D, Lynch JK, NICHD-NINDS Perinatal Stroke Workshop Participants. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007;120(3):609-616. Kirton A, DeVeber G, Pontigon AM, MacGregor D, Shroff M. Presumed perinatal ischemic stroke: vascular classification predicts outcomes. Ann Neurol.2008;63(4):436-443. Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, DeBaun MR, deVeber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER; American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke. 2019;50(3):e51-e96. Pediatric Supplemental?Highly Recommended 1.00 2020-05-20 10:01:27.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58924 Focal Cerebral Arteriopathy Severity Score (FCASS) - follow up sum score FollowUpSumScore Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Follow-up score Numeric Values

For follow-up imaging, sum the five individual scores (without weighting) and apply the delta point if applicable. The maximum follow-up score is 21 (20 plus the delta point).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:54:59.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58899 Causative Classification System (CCS) - cardiac embolism phenotype status CCSCardiacEmbolismPhntypStat The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of cardiac embolism. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 12:58:14.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58914 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy primary diagnosis subtype classification status VIPSArtpthyPrmyDgnSbtypClsStat The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Indicate the subtype based on the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. No arteriopathy;Possible arteriopathy;Definite arteriopathy An isolated arterial occlusion in the context of clinical history and/or parenchymal imaging that typifies cardioembolism;An isolated arterial occlusion that could be attributable to either cardioembolism or an in situ arterial abnormality;The imaging appearance of an in situ arterial abnormality (stenosis, irregularity, occlusion, banding, pseudoaneurysm, dissection flap) not attributable to an exogenous thrombus (e.g., cardioembolism) and not considered a normal developmental variant. Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:14:49.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58925 Sophia chance findings during routine imaging other text SophiaChncFindDurRoutImgOthTxt The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context. Chance findings during routine imaging, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 1.00 2020-05-20 12:03:24.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58901 Causative Classification System (CCS) - small artery occlusion phenotype status CCSSmlArtOcclsnPhntypStat The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of small artery occlusion. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 13:04:42.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58915 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy secondary diagnosis subtype classification status VIPSArtpthyScdyDgnSbtypClsStat The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. If definite arteriopathy, indicate secondary diagnosis Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:40:29.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58902 Causative Classification System (CCS) - other uncommon cause phenotype status CCSOthrUncmnCausePhntypStat The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of other uncommon causes. Major;Absent Major;Absent Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 13:34:35.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58916 Vascular effects of Infection in Pediatric Stroke (VIPS) - focal cerebral arteriopathy type VIPSFCATyp Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Focal cerebral arteriopathy (FCA) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 11:00:31.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58904 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - atherothrombosis grade ASCODSystemAtherothrGrade The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). Evaluate the patients for the predefined phenotype of atherosclerosis (A). 0;1;2;3;9 Atherosclerosis not detected. Ruling out atherosclerosis: (1) extracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-Duplex,CTA, MRA, XRA, or autopsy, (2) intracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-TCD,MRA, CTA, XRA, or autopsy, (3) aortic arch atheroma: TEE with specific assessment of the aortic arch (when the probe is pulled back at the end of the cardiac examination, turn the probe counter clockwise and take time to watch the aortic arch) or specific aortic arch assessment with CTA;Potentially causal. Atherothrombotic stroke defined as: (1) ipsilateral atherosclerotic stenosis between 50 and 99% in an intra- or extracranial artery supplying the ischemic field, or (2) ipsilateral atherosclerotic stenosis;Causal link is uncertain. (1) ipsilateral atherosclerotic stenosis 30–50% in an intra- or extracranial artery supplying the ischemic field, or (2) aortic plaque =4 mm without mobile lesion;Causal link is unlikely, but the disease is present. (1) plaque (stenosis <30%) in an intra- or extracranial artery, ipsilateral to the infarct area, (2) aortic plaque <4 mm without mobile thrombus, (3) stenosis (any degree) or occlusion in a cerebral artery not supplying the infarct area (e.g. contralateral side or opposite circulation), (4) history of myocardial infarction, coronary revascularization or peripheral arterial disease, (5) ipsi- or bilateral atherosclerotic stenosis 50–99% with bihemispheric MR-DWI lesion;Incomplete workup. US-Duplex, US-TCD or CTA, or MRA, or XRA or autopsy not performed. [A minimum workup is extra- and intracranial assessment of cerebral arteries – maximum workup also includes transesophageal assessment of the aortic arch (or a default CTA of the aortic arch)] Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-19 13:41:48.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58917 Focal Cerebral Arteriopathy Severity Score (FCASS) - supraclinoid internal carotid artery score scale FCASSSupraclinoidICAScoreScl The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score supraclinoid ICA 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:11:28.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14244 Subarachnoid hemorrhage etiology type SAHEtiologyTyp Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowed. Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowed. Indicate the presumed cause(s) of the subarachnoid hemorrhage (SAH). Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14255 Subarachnoid hemorrhage volume total measurement SubarachHemVolTotalMeasr Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Numeric Values

The total amount of subarachnoid blood (sum score) is calculated by adding the 10 sub-scores. The range for the total is 0 - 30 (integers). This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 30 milliliter
C13832 Graeb intraventricular hemorrhage (IVH) scale - left lateral ventricle score GraebIVHScaleLeftLatVentScore Indicates Graeb IVH Scale - Left lateral ventricle score Indicates Graeb IVH Scale - Left lateral ventricle score Left lateral ventricle score 1;2;3;4 Trace amount of blood or mild bleeding;< Half of the ventricle filled with blood;> Half of the ventricle filled with blood;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14268 Sophia time detection type SophiaTimeDetTyp Time of detection of the stroke event in the participant/subject Time of detection of the stroke event in the participant/subject Identify the time of detection of the stroke event in the participant/subject. Fetal;Neonatal early/late (day after birth);Presumed fetal or perinatal Fetal;Neonatal early/late (day after birth);Presumed fetal or perinatal Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14228 Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) - standard sub type BWCYSSStandardSubTyp Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Identify the Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System. Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Alphanumeric

Choose all that apply, following the additional coding instructions. Two "Probable" diagnoses are allowed if criteria were met for two conditions of equal priority. [High priority diagnoses = Atherosclerotic vasculopathy, Non-atherosclerotic vasculopathy, Cardiac/transcardiac embolism, and Hematologic/other. Lower priority diagnoses = Vasculopathy of uncertain cause (lacunar), Migrainous, Oral contraceptive and exogenous estrogen use, Other drug related, and Indeterminate.] However, a lower priority diagnosis cannot be coded as probable when a higher priority probable or possible diagnosis is present; the lower priority diagnosis has to be assigned a possible label.

Johnson CJ, Kittner SJ, McCarter RJ, Sloan MA, Stern BJ, Buchholz D, Price TR. Interrater reliability of an etiologic classification of ischemic stroke. Stroke. 1995;26(1):46-51. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14245 Hunt and Hess scale HuntHessScale This is a 5 level scale for classifying the severity of Subarachnoid Hemorrhage (SAH), the higher the score the lower the likelihood of survival. This is a 5 level scale for classifying the severity of Subarachnoid Hemorrhage (SAH), the higher the score the lower the likelihood of survival. Hunt Hess scale 1;2;3;4;5 Asymptomatic, mild headache, slight nuchal rigidity;Moderate to severe headache, nuchal rigidity, no neurologic deficit other than cranial nerve palsy;Drowsiness/confusion, mild focal neurologic deficit;Stupor, moderate-severe hemiparesis;Coma, decerebrate posturing Numeric values

Choose the best score

Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968;28(1):14-20. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14256 World Federation of Neurological Surgeons (WFNS) - grading system subarachnoid hemorrhage scale WFNSGraSySubHemScale World Federation of Neurological Surgeons (WFNS) Grading System for Subarachnoid Hemorrhage Scale World Federation of Neurological Surgeons (WFNS) Grading System for Subarachnoid Hemorrhage Scale World Federation of Neurological Surgeons (WFNS) Grading System for subarachnoid hemorrhage scale. 1;2;3;4;5 Glasgow Coma Scale of 15 AND a major focal deficit is absent;Glasgow Coma Scale of 13 - 14 AND a major focal deficit is absent;Glasgow Coma Scale of 13 - 14 AND a major focal deficit is present;Glasgow Coma Scale of 7 - 12 AND a major focal deficit is present/absent;Glasgow Coma Scale of 3 - 6 AND a major focal deficit is present/absent Numeric values

Glasgow Coma Scale = (Score for eye opening) + (score for best verbal response) + (score for best motor response)

Drake CG, Hunt WE, Sano K, et al. Report of World Federation of Neurological Surgeons Committee on a universal subarachnoid hemorrhage grading scale. J Neurosurg. 1988; 68(6):985-986. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13833 Graeb intraventricular hemorrhage (IVH) scale - third ventricle score GraebIVHScaleThirdVentScore Indicates Graeb IVH Scale - Third ventricle score Indicates Graeb IVH Scale - Third ventricle score Third ventricle score 1;2 Blood present without dilatation;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14269 Sophia signs symptoms presentation type SophiaSignSymPresTyp Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Identify the signs and symptoms exhibited by the neonate at presentation. Seizures;Other neurological signs, specify;Focal EEG changes;Chance findings during routine imaging, specify Seizures;Other neurological signs, specify;Focal EEG changes;Chance findings during routine imaging, specify Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14230 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - atherothrombotic grade ASCOSystemAtherothrGrade The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). Evaluate the patients for the predefined phenotype of atherosclerosis (A). 0;1;2;3;9 0=No disease is present.;1=Definitely a potential cause of the index stroke defined as: (a) Patients with any atherosclerotic stenosis 70–99% in an intra-/or extracranial artery supplying the ischemic field diagnosed by level A or B evidence| or (b) Any atherosclerotic stenosis <70% in an intra-/or extracranial artery supplying the ischemic field with attached luminal thrombus diagnosed by level A or B evidence| or (c) A mobile thrombus in the aortic arch| or (d) Occlusion with imaging evidence of atherosclerosis in an intra-/or extracranial artery supplying the ischemic field.;2=Causality uncertain: (a) Patients with any atherosclerotic stenosis 70–99% in an intra-/or extracranial artery supplying the ischemic field diagnosed by level C evidence| or (b) Any atherosclerotic stenosis <70% in an intra-/or extracranial artery supplying the ischemic field with attached luminal thrombus diagnosed by level C evidence| or (c) Aortic arch plaques >4 mm in thickness without a mobile component.;3=Unlikely a direct cause of index stroke (but disease is present): (a) Presence of carotid or vertebral artery plaque without stenosis| or (b) Aortic arch plaque <4 mm| or (c) Stenosis (any degree) in a brain artery, contralateral to the brain infarction or in the opposite circulation (either posterior or anterior circulation)| or (d) History of myocardial infarction or coronary revascularization or peripheral arterial disease.;9=Cannot be graded because no tests were performed. Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14246 Fisher scale FisherScale Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Fisher scale 1;2;3;4 No blood detected;Diffuse deposition of thin layer w/ all vertical layers of blood (interhemispheric fissure, insular cistern, ambient cistern) < 1 mm thick;Vertical Layers of blood 1 mm thick or localized clots (clots defined as > 3 x 5 mm);diffuse or no subarachnoid blood, but w/ intracerebral or intraventricular clots Numeric values

Choose the best score

Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 1980;6(1):1-9. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14257 Childhood stroke type ChildhoodStrokeTyp Indicates the type of clinical stroke suffered by the child. Indicates the type of clinical stroke suffered by the child. Indicate the type of clinical stroke suffered by the child. Childhood arterial ischemic stroke;Childhood intracerebral hemorrhage;Childhood subarachnoid hemorrhage;Childhood intraventricular hemorrhage;Childhood TIA;Childhood Silent Stroke;Childhood cerebral venous thrombosis Childhood arterial ischemic stroke;Childhood intracerebral hemorrhage;Childhood subarachnoid hemorrhage;Childhood intraventricular hemorrhage;Childhood TIA;Childhood Silent Stroke;Childhood cerebral venous thrombosis Alphanumeric

Choose one per stroke event.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13834 Graeb intraventricular hemorrhage (IVH) scale - fourth ventricle score GraebIVHScaleFourVentScore Indicates Graeb IVH Scale - Fourth ventricle score Indicates Graeb IVH Scale - Fourth ventricle score Fourth ventricle score 1;2 Blood present without dilatation;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14270 Sophia stroke vessels affected type SophiaStrokVesselAffectTyp Vessel(s) affected by the stroke event. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Vessel(s) affected by the stroke event. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Identify the vessel affected by the stroke event. Arterial cortical;Arterial perforator;Brainstem or spinal cord arteries;Sinus;Deep or Pial Vein;Lobar or Subarachnoid Arterial cortical;Arterial perforator;Brainstem or spinal cord arteries;Sinus;Deep or Pial Vein;Lobar or Subarachnoid Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14231 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - small vessel grade ASCOSystemSmallVesselGrade The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of small vessel disease (S). The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of small vessel disease (S). Evaluate the patients for the predefined phenotype of small vessel disease (S). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke: Deep branch artery stroke: small, deep infarct with diameter <15 mm on MRI (or CT) in the territory corresponding to symptoms and either (b) One or several old or silent lacunar infarcts in territories different from the index stroke or (c) Leukoaraiosis on MRI (or CT), microbleeds on MRI (gradient echo imaging), dilatation of the perivascular spaces on MRI (or CT) or (d) Recent repeated similar TIAs – when they preceded the brain infarct by 1 month or less and attributable to the same territory as the subsequent BI (which increase the prediction for lacunar stroke from 57 to 80%, and are therefore supportive).;Causality uncertain: (a) Single, deep branch artery stroke or (b) Clinical syndrome suggestive of deep branch artery stroke with no MRI/CT evidence of stroke (clinical syndrome suggestive of a deep branch artery stroke – classic lacunar syndromes: pure motor hemiparesis, pure sensory syndrome, ataxic hemiparesis, dysarthria clumsy-hand syndrome, and sensorimotor syndrome or other 'nonlacunar' clinical syndromes. e.g. hemichorea, hemiballism, isolated dysarthria, etc.).;Unlikely a direct cause of index stroke (but disease is present): Leukoaraiosis on MRI (or CT), and/or microbleeds on MRI (gradient echo imaging), and/or dilatation of perivascular spaces on MRI (or CT), and/or one or several lacunar infarcts (silent or old) in territories different from the index stroke.;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14247 Modified fisher scale ModFisherScale Modified Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Modified Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Modified Fisher scale 0;1;2;3;4 No subarachnoid hemorrhage or intraventricular hemorrhage;subarachnoid hemorrhage less than 1 mm thick, no intraventricular hemorrhage;subarachnoid hemorrhage less than 1 mm thick, with intraventricular hemorrhage;subarachnoid hemorrhage more than 1 mm thick, no intraventricular hemorrhage;subarachnoid hemorrhage more than 1 mm thick, with intraventricular hemorrhage Numeric values

Choose the best score

Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, MacDonald RL, Mayer SA. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery. 2006 Jul;59(1):21-7; discussion 21-7. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14258 Perinatal stroke type PerinatalStrokeTyp Indicates the type of clinical stroke suffered by the neonate. Indicates the type of clinical stroke suffered by the neonate. Indicate the type of clinical stroke suffered by the neonate. Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Alphanumeric

Choose one per stroke event.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13835 Graeb intraventricular hemorrhage (IVH) scale - total score GraebIVHScaleTotaScore Indicates Graeb IVH Scale - total Score Indicates Graeb IVH Scale - total Score Total score Numeric Values

To calculate the total, sum the scores for the ventricles. Maximum score is 12.

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 12
C14271 Sophia imaging stroke composite diagnosis method type SophiaImgStrokCompDiaMethTyp Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Identify the imaging method at detection. Ultrasound;MRI/MRA/MRV;CT;Other, specify Ultrasound;MRI/magnetic resonance angiography/magnetic resonance venography;CT;Other, specify Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14232 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - cardioembolic grade ASCOSystemCardioembGrade The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C). The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C). Evaluate the patients for the predefined phenotype of cardiac source (C). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke: (a) Mitral stenosis, (b) Prosthetic heart valve, (c) Myocardial infarction within the past 4 weeks, (d) Mural thrombus in left cavities, (e) Left ventricular aneurysm, (f) Any documented history or permanent or transient atrial fibrillation or flutter with or without spontaneous echo contrast or left atrial thrombus, (g) Sick sinus syndrome, (h) Dilated cardiomyopathy, (i) Ejection fraction <35%, (j) Endocarditis, (k) Intracardiac mass, (l) PFO plus in situ thrombosis, (m) PFO plus concomitant PE or DVT preceding the brain infarction.;Causality uncertain: (a) PFO and ASA, (b) PFO and concomitant DVT or PE (but not preceding the index stroke), (c) Spontaneous echo contrast, (d) Apical akinesia of the left ventricle and impaired ejection fraction (but >35%), (e) Only suggested by history of myocardial infarction or palpitation and multiple repeated brain infarcts on both sides or in both the anterior and posterior circulation, (f) Only suggested by abdominal CT/MRI or autopsy demonstration of the presence of systemic infarction (e.g. kidney, splenic, mesenteric) or lower limb embolism (in addition to the index stroke).;Unlikely a direct cause of index stroke: One of the following abnormalities: PFO, ASA, valvular strands, mitral annulus calcification, calcified aortic valve, nonapical akinesia of the left ventricle.;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

CSV