CDE Detailed Report

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

Congenital disorders include malformations or other pathology of bones (infantile idiopathic scoliosis (Dobbs et al. 2002; Pahys et al. 2009), congenital spinal canal stenosis (Kotil et al. 2007), achondroplasia (Laederich and Horton 2010; Benglis and Sandberg 2007)), muscles (muscular dystrophy) or neural tissues (syringohydromyelia). These also include combined multi system/organ disorders such as myelomenigocele (MMC) (Guille et al. 2006; Rajpal et al. 2007), malformations of the craniocervical junction (i.e. Arnold Chiari type, congenital stenosis, Klippel-Feil anomalies etc. ) (Fernandez et al. 2009; Nakamura et al. 2009; Pahys et al. 2009) or tethered cord (Kramer et al. 2009; Iskandar et al. 2001). Sometimes, these conditions are present in early childhood but only become
symptomatic during adolescence or advancing age. This may be due to progression or unmasking of the condition.

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

Check Yes or No to indicate if the medical condition/disease is still present

Having a spinal cord lesion does not protect against having other fairly prevalent endocrine abnormalities. Autoimmune thyroid dysfunction may be precipitated or made worse by an acute stressful event (Ladenson et al. 2000; Sonino et al. 1993).

These codes include conditions present prior to the spinal cord lesion, which may influence the outcomes related to the cardiovascular functions. Altered autonomic control routinely leads to instability of blood pressure following spinal cord lesions. Hypotension is common in acute and chronic spinal cord lesions. In addition, intermittent hypertension can be associated with noxious or non-noxious stimuli and resultant autonomic dysreflexia. Preexisting abnormalities of blood pressure can influence these changes.
Hypertension: (arterial blood pressure >140/90 mmHg).
Hypotension: (systolic arterial blood pressure Orthostatic hypotension: Symptomatic or asymptomatic decrease in blood pressure usually exceeding 20 mmHg systolic or 10 mmHg diastolic on moving from the supine to an upright position.
Deep vein thrombosis: Thrombosis of the deep veins of the legs, pelvis or arms, due to coagulopathy, stasis, or endothelial injury.
Pre-existing neuropathies (e.g. diabetic or alcoholic neuropathy) and other conditions associated with autonomic dysfunctions (e.g. Parkinson's disease, multiple sclerosis, traumatic brain injury) can affect altered cardiovascular functions post spinal cord lesion, and should therefore be included.

Degenerative spine disorders present with aging. The most common disorders are lumbar (Abbas et al. 2010; Yasar et al. 2009) and cervical (Tracy & Bartleson 2010; Fehlings & Arvin 2009) spinal canal stenosis, spondylosis and degenerative systemic disorders (like diffuse idiopathic skeletal hyperostosis (DISH) and rheumatoid arthritis). These disorders typically develop slowly with the spinal cord often adapting to extensive morphological changes before notable
impairment. The onset of impairments is usually slow and insidious and therefore not noticed by individuals for a considerable time. However, the degenerative changes can increase susceptibility to spinal cord lesions from relatively minor insults, e.g. minor falls with mild extension/flexion trauma inducing a central cord syndrome (Matz et al. 2009).

Dyslipidemias may be worsened by a reduction in the serum HDL cholesterol value in those with acute or chronic SCI. Therefore, to have the ability to determine the effect of SCI per se on the lipid profile, this information, if available, should be provided (if several lipid profiles are available, the most recent values prior to SCI should be provided), along with the date obtained. The units of measurement to be used in this data set are mg/dL.

Other, specify

Degenerative spine disorders present with aging. The most common disorders are lumbar (Abbas et al. 2010; Yasar et al. 2009) and cervical (Tracy & Bartleson 2010; Fehlings & Arvin 2009) spinal canal stenosis, spondylosis and degenerative systemic disorders (like diffuse idiopathic skeletal hyperostosis (DISH) and rheumatoid arthritis). These disorders typically develop slowly with the spinal cord often adapting to extensive morphological changes before notable
impairment. The onset of impairments is usually slow and insidious and therefore not noticed by individuals for a considerable time. However, the degenerative changes can increase susceptibility to spinal cord lesions from relatively minor insults, e.g. minor falls with mild extension/flexion trauma inducing a central cord syndrome (Matz et al. 2009).

These codes include endocrine and metabolic conditions diagnosed prior to the spinal cord lesion that may negatively impact health and function after spinal cord lesion.

Degenerative spine disorders present with aging. The most common disorders are lumbar (Abbas et al. 2010; Yasar et al. 2009) and cervical (Tracy & Bartleson 2010; Fehlings & Arvin 2009) spinal canal stenosis, spondylosis and degenerative systemic disorders (like diffuse idiopathic skeletal hyperostosis (DISH) and rheumatoid arthritis). These disorders typically develop slowly with the spinal cord often adapting to extensive morphological changes before notable
impairment. The onset of impairments is usually slow and insidious and therefore not noticed by individuals for a considerable time. However, the degenerative changes can increase susceptibility to spinal cord lesions from relatively minor insults, e.g. minor falls with mild extension/flexion trauma inducing a central cord syndrome (Matz et al. 2009).

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

Record the appropriate body system for each line of medical history.

*For specific questions related to cardiovascular, endocrine, respiratory, musculoskeletal, genitourinary, neurological and gastrointestinal systems, please see the Exploratory list of questions which may be applicable.

Choose one
Osteoporosis present prior to the spinal cord lesion would be expected to be accelerated because of the adverse effects of paralysis and immobilization on the skeleton below the level of SCI (Biering-Sorensen et al. 1990; NIH Consensus Development Panel, 2001; National Osteoporosis Foundation, 2008). The WHO diagnostic classification of osteoporosis cannot be applied to T-scores from measurements other than dual energy x-ray absorptiometry (DXA) at standard measurement sites (i.e., at the femoral neck, total femur, lumbar spine, or one-third radius). If DXA is not performed, the diagnosis of osteoporosis may be suggested if assessed by other diagnostic methods (i.e., x-ray, quantitative computerized tomography (qCT) or peripheral qCT, in conjunction with clinical risk factors (Baim et al. 2008). Therefore, if osteoporosis is to be diagnosed according to accepted guidelines, DXA must be the method used, or if presumptively diagnosed from methods that are not validated to make the diagnosis of osteoporosis, or performed by qualitative methods, this would be designated as Other method (e.g., CT, radiograph).

Congenital disorders include malformations or other pathology of bones (infantile idiopathic scoliosis (Dobbs et al. 2002; Pahys et al. 2009), congenital spinal canal stenosis (Kotil et al. 2007), achondroplasia (Laederich and Horton 2010; Benglis and Sandberg 2007)), muscles (muscular dystrophy) or neural tissues (syringohydromyelia). These also include combined multi system/organ disorders such as myelomenigocele (MMC) (Guille et al. 2006; Rajpal et al. 2007), malformations of the craniocervical junction (i.e. Arnold Chiari type, congenital stenosis, Klippel-Feil anomalies etc. ) (Fernandez et al. 2009; Nakamura et al. 2009; Pahys et al. 2009) or tethered cord (Kramer et al. 2009; Iskandar et al. 2001). Sometimes, these conditions are present in early childhood but only become
symptomatic during adolescence or advancing age. This may be due to progression or unmasking of the condition.

Systemic neuro-degenerative disorders comprise conditions like multiple sclerosis, amyotrophic lateral sclerosis and others. They typically occur in adults and are characterized by an acute or chronic progressive course, which can eventually present as tetra/paraplegia.

Dyslipidemias may be worsened by a reduction in the serum HDL cholesterol value in those with acute or chronic SCI. Therefore, to have the ability to determine the effect of SCI per se on the lipid profile, this information, if available, should be provided (if several lipid profiles are available, the most recent values prior to SCI should be provided), along with the date obtained. The units of measurement to be used in this data set are mg/dL.

Choose one. If this question is answered NO then the rest of the form is blank. If the question is answered YES then the medical history for at least one body system should be recorded