CDE Detailed Report
Disease: Multiple Sclerosis
Subdomain Name: Imaging Diagnostics
CRF: Imaging Analysis Technique and Results - Baseline
Displaying 51 - 81 of 81
Subdomain Name: Imaging Diagnostics
CRF: Imaging Analysis Technique and Results - Baseline
Displaying 51 - 81 of 81
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guidance) | Subdomain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C15376 | Imaging other unspecified lesion count | ImgOthUnspecLesnCt | Total number of other lesions whose type is not specified | Total number of other lesions whose type is not specified | Number of other lesions whose type is not specified | Numeric Values |
Exploratory for Imaging studies No additional instructions |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C15516 | Imaging tissue integrity normal appearing white matter measurement indicator | ImgTissueIntegApprWMInd | Whether measurements of the tissue integrity of normal appearing white matter were taken | Whether measurements of the tissue integrity of normal appearing white matter were take | Normal Appearing WM | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric |
Answer for all tissue integrity types. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15415 | Imaging gray matter volume measurement | ImgGrayMattVolMeasr | Volume of the gray matter | Volume of the gray matter | Gray matter volume | Numeric Values |
Exploratory for Imaging studies Answer questions and sub-questions for gray matter volume, or gray matter volume fraction but not both. Record in mL and use 2 decimal places. Acceptable range is 20.00 - 2000.00. This element is considered exploratory for imaging study. |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
20 | 2000 | milliliter | |||||||
| C19000 | Imaging Gadolinium-enhancing lesion technique other text | ImgGdEnLesnTechOTH | The free-text field related to 'Imaging Gadolinium-enhancing lesion technique type' specifying other text. Method used to determine the lesions for gadolinium (Gd)-enhancing lesions on T1+Gd image | The free-text field related to 'Imaging Gadolinium-enhancing lesion technique type' specifying other text. Method used to determine the lesions for gadolinium (Gd)-enhancing lesions on T1+Gd image | Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C15321 | Imaging T2W brain lesion volume measurement | ImgT2wBrnLesnVolMeasr | Total volume of all focal T2-hyperintense brain lesions | Total volume of all focal T2-hyperintense brain lesions | Total volume of brain lesions on T2W image | Numeric Values |
Highly recommended for: Imaging studies Record total volume of white matter lesions on T2W image in cc. Use 2 decimal places. Expected range 0 - 1000. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
0 | 1000 | cubic centimeter | |||||||
| C15446 | Imaging ventricular volume technique type | ImgVentrclVolTechTyp | Image analysis method used to calculate ventricular volume | Image analysis method used to calculate ventricular volume | Technique Used | Automated;Manual;Semi-automated | Automated;Manual;Semi-automated | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15474 | Imaging diffusion result value | ImgDiffusionReslt | The numeric value for diffusion tensor imaging (DTI) result | The numeric value for diffusion tensor imaging (DTI) result | N/A | Numeric Values |
Record a value for each diffusion tensor imaging (DTI) measure and each region of the brain. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-16 14:01:43.01 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C15379 | Imaging T2W image technique type | ImgT2WImgTechTyp | Method used to determine the total volume of white matter hyperintensities on T2-weighted image | Method used to determine the total volume of white matter hyperintensities on T2-weighted image | Technique Used | Manual tracing;Semi-automated (verified by experienced reader);Fully automated segmentation (verified by experienced reader);Other, specify | Manual tracing;Semi-automated (verified by experienced reader);Fully automated segmentation (verified by experienced reader);Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15517 | Imaging tissue integrity normal appearing gray matter measurement indicator | ImgTissueIntegApprGrayMttrInd | Whether measurements of the tissue integrity of normal appearing gray matter were taken | Whether measurements of the tissue integrity of normal appearing gray matter were take | Normal Appearing GM | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric |
Answer for all tissue integrity types. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15418 | Imaging gray matter volume fraction value | ImgGrayMattVolFractVal | Volume of gray matter in the brain or ratio of gray matter volume to total intracranial volume or other head-size normalization volume | Ratio of gray matter volume to total intracranial volume or other head-size normalization volume | Gray matter volume fraction | Numeric Values |
Exploratory for Imaging studies Answer questions and sub-questions for gray matter volume, or gray matter volume fraction but not both. Use 4 decimal places. Acceptable range is 0.2000 - 0.8000. |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
0.2 | 0.8 | ||||||||
| C19001 | Imaging T1 hypointense lesion technique other text | ImgT1HypinLesnTechOTH | The free-text field related to 'Imaging T1 hypointense lesion technique type' specifying other text. Method used to determine the total number of T1 hypointense lesions | The free-text field related to 'Imaging T1 hypointense lesion technique type' specifying other text. Method used to determine the total number of T1 hypointense lesions | Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C15329 | Imaging T2 lesion total count performed indicator | ImgT2LesnTtlCtPerfInd | Whether total counts of the number of focal T2-hyperintense brain lesions was performed | Whether total counts of the number of focal T2-hyperintense brain lesions was performed | Total T2 lesion counts | Done;Not done | Done;Not done | Alphanumeric |
Choose one |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15449 | Imaging hippocampus volume measurement | ImgHippoVolMeasr | Hippocampus volume measurement | Hippocampus volume measurement | Hippocampus | Numeric Values |
Record in mL and use 2 decimal places. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
milliliter | |||||||||
| C15478 | Imaging gray matter lesion technique type | ImgGrayMattLesnTechTyp | Method used to determine the number of lesions | Method used to determine the number of lesions | Technique Used | Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify | Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15381 | Imaging Gadolinium-enhancing lesion total volume measurement | ImgGdEnLesnTtlVolMeasr | Total volume of all focal lesions that are gadolinium (Gd)-enhancing on T1-weighted brain images | Total volume of all focal lesions that are gadolinium-enhancing on T1-weighted brain images | Total volume of Gd-enhancing lesions | Numeric Values |
Record total volume of Gd-enhancing lesions in cc. Use 2 decimal places. Expected range 0 - 1000. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
0 | 1000 | cubic millimeter | |||||||
| C15518 | Imaging tissue integrity other regional measurements indicator | ImgTissueIntegRegnlMeasInd | Whether measurements of the tissue integrity of other brain regions were taken | Whether measurements of the tissue integrity of other brain regions were take | Other Regional Measurements | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric |
Answer for all tissue integrity types. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15420 | Imaging brain volume technique type | ImgBrainVolTechTyp | Image analysis method used to calculate whole brain volume | Image analysis method used to calculate whole brain volume | Technique Used | Other, specify;Absolute brain volume (non-normalized);Normalized brain volume (e.g., SIENAX) | Other, specify;Absolute brain volume (non-normalized);Normalized brain volume (e.g., SIENAX) | Alphanumeric |
Absolute brain volume = straight volume measurement with no normalization for head size. Normalized brain volume = techniques which calculate volume after transformation to standard space |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C19002 | Imaging brain volume technique other text | ImgBrainVolTechOTH | The free-text field related to 'Imaging brain volume technique type' specifying other text. Image analysis method used to calculate whole brain volume | The free-text field related to 'Imaging brain volume technique type' specifying other text. Image analysis method used to calculate whole brain volume | Other, specify | Alphanumeric |
Absolute brain volume = straight volume measurement with no normalization for head size. Normalized brain volume = techniques which calculate volume after transformation to standard space |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C15338 | Imaging T2 lesion total count | ImgT2LesnTtlCt | Total number of focal T2-hyperintense brain lesions | Total number of focal T2-hyperintense brain lesions | Total number of T2 lesions | Numeric Values |
Highly recommended for: Clinical trials of disease-modifying therapies. Range of 0 - 1000. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
0 | 1000 | ||||||||
| C15453 | Imaging thalamus volume measurement | ImgThalVolMeasr | Thalamus volume measurement | Thalamus volume measurement | Thalamus | Numeric Values |
Record in mL and use 2 decimal places. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
milliliter | |||||||||
| C15490 | Imaging regional brain volume technique type | ImgRegBrainVolTechTyp | Image analysis method used to calculate other regional volume or regional volume fractions | Image analysis method used to calculate other regional volume or regional volume fractions | Technique Used | Brain structure volumes;Central cerebral volume;Cortical thickness | Brain structure volumes;Central cerebral volume;Cortical thickness | Alphanumeric |
Exploratory for Imaging studies Complete as many times as needed. |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15386 | Imaging Gadolinium-enhancing lesion technique reference name | ImgGdEnLesnTeRefName | Name of software package used, website, and/or a citation to a journal article referencing the particular technique used to find Gadolinium-enhancing lesions | Name of software package used, website, and/or a citation to a journal article referencing the particular technique used to find Gadolinium-enhancing lesion | Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual) | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations | 255 |
Free-Form Entry |
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| C15646 | Imaging posterior fossa lesion count | ImgPostrFossaLesnCt | Total number of focal T2-hyperintense brain lesions that are in contact with the posterior fossa (brainstem or cerebellum) | Total number of focal T2-hyperintense brain lesions that are in contact with the posterior fossa (brainstem or cerebellum) | Number of posterior fossa lesions | Numeric Values |
Expected range 0 - 1000. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
0 | 1000 | ||||||||
| C15423 | Imaging gray matter lesion count | ImgGrayMattLesnCt | Total number of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter | Total number of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter | Total number of gray matter lesions | Numeric Values |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C19003 | Imaging brain volume fraction technique other text | ImgBrainVolFractTechOTH | The free-text field related to 'Imaging brain volume fraction technique type' specifying other text. Image analysis method used to calculate whole brain volume fraction | The free-text field related to 'Imaging brain volume fraction technique type' specifying other text. Image analysis method used to calculate whole brain volume fraction | Other, specify | Alphanumeric |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C15346 | Imaging regional T2 lesion count performed indicator | ImgRgnlT2LesnCntPerfInd | Whether regional T2 lesion counts were performed | Whether regional T2 lesion counts were performed | Regional T2 lesion counts | Done;Not done | Done;Not done | Alphanumeric |
Choose one |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C15457 | Imaging spinal cord lesion count | ImgSpinCordLesnCt | Total number of lesions located at any level of the spinal cord | Total number of lesions located at any level of the spinal cord | Total number of spinal cord lesions | Numeric Values |
Exploratory for Imaging studies No additional instructions |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C15491 | Imaging brain measured structure type | ImgBrainStructureTyp | The structure of the brain volume measurement | The structure of the brain volume measurement | If Brain structure volume, specify structure | Hippocampus;Lobes;Other, specify;Thalamus | Hippocampus;Lobes;Other, specify;Thalamus | Alphanumeric |
Exploratory for Imaging studies Only answered if "Brain structure volume" was answered for "Technique" |
No references available | Adult;Pediatric | Exploratory | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C15393 | Imaging T1 hypointense lesion count | ImgT1HypoLesnCt | Hypointense lesion number on T1 without antecedent T1-hypointensity on adequate prior MRI scan | Hypointense lesion number on T1 without antecedent T1-hypointensity on adequate prior MRI scan | Total number of T1 hypointense lesions | Numeric Values |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C15650 | Imaging basal ganglia lesion count | ImgBasGangLesnCt | Total number of lesions located in the basal ganglia (excluding the thalamus) | Total number of lesions located in the basal ganglia (excluding the thalamus) | Number of basal ganglia lesions | Numeric Values |
No additional instructions |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
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| C15425 | Imaging gray matter lesion volume measurement | ImgGrayMattLesnVolMeasr | Volume of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter | Volume of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter | Total volume of gray matter lesions | Numeric Values |
Record total volume of gray matter lesions in ml. Use 2 decimal places. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-06-11 00:00:00.0 | Imaging Analysis Technique and Results - Baseline | Imaging Diagnostics | Assessments and Examinations |
Free-Form Entry |
milliliter |
