CDE Detailed Report

Disease: Multiple Sclerosis
Sub-Domain: Imaging Diagnostics
CRF: Imaging Analysis Technique and Results - Baseline

Displaying 1 - 50 of 80
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C15381 Imaging Gadolinium-enhancing lesion total volume measurement ImgGdEnLesnTtlVolMeasr Total volume of all focal lesions that are gadolinium (Gd)-enhancing on T1-weighted brain images Total volume of all focal lesions that are gadolinium-enhancing on T1-weighted brain images Total volume of Gd-enhancing lesions Numeric Values

Record total volume of Gd-enhancing lesions in cc. Use 2 decimal places. Expected range 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000 cubic millimeter
C15478 Imaging gray matter lesion technique type ImgGrayMattLesnTechTyp Method used to determine the number of lesions Method used to determine the number of lesions Technique Used Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15420 Imaging brain volume technique type ImgBrainVolTechTyp Image analysis method used to calculate whole brain volume Image analysis method used to calculate whole brain volume Technique Used Other, specify;Absolute brain volume (non-normalized);Normalized brain volume (e.g., SIENAX) Other, specify;Absolute brain volume (non-normalized);Normalized brain volume (e.g., SIENAX) Alphanumeric

Absolute brain volume = straight volume measurement with no normalization for head size. Normalized brain volume = techniques which calculate volume after transformation to standard space

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15518 Imaging tissue integrity other regional measurements indicator ImgTissueIntegRegnlMeasInd Whether measurements of the tissue integrity of other brain regions were taken. Whether measurements of the tissue integrity of other brain regions were taken. Other Regional Measurements Yes;No;Unknown Yes;No;Unknown Alphanumeric

Answer for all tissue integrity types.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15338 Imaging T2 lesion total count ImgT2LesnTtlCt Total number of focal T2-hyperintense brain lesions Total number of focal T2-hyperintense brain lesions Total number of T2 lesions Numeric Values

Highly recommended for: Clinical trials of disease-modifying therapies.

Range of 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000
C15453 Imaging thalamus volume measurement ImgThalVolMeasr Thalamus volume measurement Thalamus volume measurement Thalamus Numeric Values

Record in mL and use 2 decimal places.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

milliliter
C19002 Imaging brain volume technique other text ImgBrainVolTechOTH The free-text field related to 'Imaging brain volume technique type' specifying other text. Image analysis method used to calculate whole brain volume The free-text field related to 'Imaging brain volume technique type' specifying other text. Image analysis method used to calculate whole brain volume Other, specify Alphanumeric

Absolute brain volume = straight volume measurement with no normalization for head size. Normalized brain volume = techniques which calculate volume after transformation to standard space

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15386 Imaging Gadolinium-enhancing lesion technique reference name ImgGdEnLesnTeRefName Name of software package used, website, and/or a citation to a journal article referencing the particular technique used to find Gadolinium-enhancing lesions. Name of software package used, website, and/or a citation to a journal article referencing the particular technique used. Technique reference (i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual) Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 255

Free-Form Entry

C15490 Imaging regional brain volume technique type ImgRegBrainVolTechTyp Image analysis method used to calculate other regional volume or regional volume fractions Image analysis method used to calculate other regional volume or regional volume fractions Technique Used Brain structure volumes;Central cerebral volume;Cortical thickness Brain structure volumes;Central cerebral volume;Cortical thickness Alphanumeric

Exploratory for Imaging studies

Complete as many times as needed.

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15423 Imaging gray matter lesion count ImgGrayMattLesnCt Total number of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter Total number of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter Total number of gray matter lesions Numeric Values

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C15646 Imaging posterior fossa lesion count ImgPostrFossaLesnCt Total number of focal T2-hyperintense brain lesions that are in contact with the posterior fossa (brainstem or cerebellum) Total number of focal T2-hyperintense brain lesions that are in contact with the posterior fossa (brainstem or cerebellum) Number of posterior fossa lesions Numeric Values

Expected range 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000
C15346 Imaging regional T2 lesion count performed indicator ImgRgnlT2LesnCntPerfInd Whether regional T2 lesion counts were performed Whether regional T2 lesion counts were performed Regional T2 lesion counts Done;Not done Done;Not done Alphanumeric

Choose one

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15457 Imaging spinal cord lesion count ImgSpinCordLesnCt Total number of lesions located at any level of the spinal cord Total number of lesions located at any level of the spinal cord Total number of spinal cord lesions Numeric Values

Exploratory for Imaging studies

No additional instructions

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C19003 Imaging brain volume fraction technique other text ImgBrainVolFractTechOTH The free-text field related to 'Imaging brain volume fraction technique type' specifying other text. Image analysis method used to calculate whole brain volume fraction The free-text field related to 'Imaging brain volume fraction technique type' specifying other text. Image analysis method used to calculate whole brain volume fraction Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15393 Imaging T1 hypointense lesion count ImgT1HypoLesnCt Hypointense lesion number on T1 without antecedent T1-hypointensity on adequate prior MRI scan Hypointense lesion number on T1 without antecedent T1-hypointensity on adequate prior MRI scan Total number of T1 hypointense lesions Numeric Values

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C15491 Imaging brain measured structure type ImgBrainStructureTyp The structure of the brain volume measurement The structure of the brain volume measurement If Brain structure volume, specify structure Hippocampus;Lobes;Other, specify;Thalamus Hippocampus;Lobes;Other, specify;Thalamus Alphanumeric

Exploratory for Imaging studies

Only answered if "Brain structure volume" was answered for "Technique"

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Multiple Pre-Defined Values Selected

C15425 Imaging gray matter lesion volume measurement ImgGrayMattLesnVolMeasr Volume of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter Volume of brain lesions located in the gray matter or lesions in the subcortical white matter also involving the gray matter Total volume of gray matter lesions Numeric Values

Record total volume of gray matter lesions in ml. Use 2 decimal places.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

milliliter
C15650 Imaging basal ganglia lesion count ImgBasGangLesnCt Total number of lesions located in the basal ganglia (excluding the thalamus) Total number of lesions located in the basal ganglia (excluding the thalamus) Number of basal ganglia lesions Numeric Values

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C15351 Imaging regional T2 lesion count ImgRgnlT2LesnCt Number of regional T2 lesions Number of regional T2 lesions Regional T2 lesion counts Numeric Values

Range of 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000
C15458 Imaging spinal cord lesion anatomic site ImgSpinCordLesnAntmicSite Specifies the location of lesions in the spinal cord with respect to the different levels of vertebrae (cervical-C, thoracic-T, lumbar-L) Specifies the location of lesions in the spinal cord with respect to the different levels (C, T, L) Spinal cord lesion region C1-C7;T1-T12;L1-L5 C1-C7;T1-T12;L1-L5 Alphanumeric

Exploratory for Imaging studies

Choose all that apply

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Multiple Pre-Defined Values Selected

C19004 Imaging magnetization transfer ratio (MTR) measurement other text ImgMTRMeasrOTH The free-text field related to 'Imaging magnetization transfer ratio (MTR) measurement type' specifying other text. Magnetization transfer ratio measure The free-text field related to 'Imaging magnetization transfer ratio (MTR) measurement type' specifying other text. Magnetization transfer ratio measure N/A Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15396 Imaging T1 hypointense lesion total volume measurement ImgT1HypoLesnTtlVolMeasr Total volume of all focal T1-hypointense brain lesions (on this scan) Total volume of all focal T1-hypointense brain lesions (on this scan) Total volume of Gd-enhancing lesions Numeric Values

Include transient T1 hypointense lesions and new T1 hypointense lesions. Record in mL, use 2 decimal places.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

milliliter
C15495 Imaging other regional volumetric gap value ImgORegVolGapVal Gap on the other regional volumetric image optical slice Gap on the other regional volumetric image optical slice Gap Numeric Values

Exploratory for Imaging studies

Record value in millimeters (mm)

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1260 milliliters
C02400 Brain volumetric analysis measurement BrainVolumetrcAnlysMeasr Measured brain volume in cubic centimeters Measured brain volume in cubic centimeters Brain volume Numeric Values

Highly recommended for: Imaging studies.

Answer questions and sub-questions for brain volume, or brain volume fraction but not both. Record brain volume in mL. Use 2 decimal places. Acceptable range is 100.00 - 2000.00. The measurement should be in cubic centimeters prior to aggregation or sharing.

Duhaime AC, Gean AD, Haacke EM, Hicks R, Wintermark M, Mukherjee P, Brody D, Latour L, Riedy G; Common Data Elements Neuroimaging Working Group Members, Pediatric Working Group Members. Common data elements in radiologic imaging of traumatic brain injury. Arch Phys Med Rehabil. 2010 Nov;91(11):1661-6. [DOI: 10.1016/j.apmr.2010.07.238] Haacke, E.M., Duhaime, A.C., Gean, A.D., Riedy, G., Wintermark, M., Mukherjee, P., Brody, D.L., DeGraba, T., Duncan, T.D., and Elovic, E. (2010). Common data elements in radiologic imaging of traumatic brain injury. Journal of Magnetic Resonance Imaging 32, 516-543, DOI:10.1002/jmri.22259 Adult;Pediatric Supplemental 3.00 2013-07-20 10:21:25.65 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

cubic centimeter
C15430 Imaging volume technique reference text ImgVolTechRefTxt Name of software package used, website, and/or a citation to a journal article referencing the particular technique used to find brain volume. Name of software package used, website, and/or a citation to a journal article referencing the particular technique used to find target anatomy volume. Technique reference ( i.e. literature citation(s), MRI Acquisition Manual or Analysis Manual) Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 255

Free-Form Entry

C15652 Imaging tissue integrity measure technique type ImgTissueIntegMeasTechTyp Type of imaging sequence used Type of imaging sequence used Technique Type MTR;DTI;Spectroscopy;Other, specify MTR;DTI;Spectroscopy;Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15357 Imaging periventricular lesion count ImgPeriventLesnCt Total number of focal T2-hyperintense brain lesions that are in contact with the ventricular system Total number of focal T2-hyperintense brain lesions that are in contact with the ventricular system Number of periventricular lesions Numeric Values

Expected range 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000
C15460 Imaging spinal cord lesion location type ImgSpinCordLesnLocTyp Specifies the location of lesions with respect to cord cross-sectional area involving spinal gray matter Specifies the location of lesions with respect to cord cross-sectional area involving spinal gray matter Spinal cord lesions location Anterior;Posterior;Lateral Anterior;Posterior;Lateral Alphanumeric

Exploratory for Imaging studies

No additional instructions

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Multiple Pre-Defined Values Selected

C19005 Imaging gray matter lesion technique other text ImgGrayMattLesnTechOTH The free-text field related to 'Imaging gray matter lesion technique type' specifying other text. Method used to determine the number of lesions The free-text field related to 'Imaging gray matter lesion technique type' specifying other text. Method used to determine the number of lesions Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15397 Imaging Gadolinium-enhancing lesion technique type ImgGdEnLesnTechTyp Method used to determine the lesions for gadolinium (Gd)-enhancing lesions on T1+Gd image Method used to determine the lesions for Gadolinium-enhancing lesions on T1+Gadolinium image Technique Used Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation and counting;Other, specify Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation and counting;Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15498 Imaging spinal cord lesion technique type ImgSpinCordLesnTechTyp Method used to determine the number of lesions located in the spinal cord Method used to determine the number of lesions located in the spinal cord Technique Used Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify Visual determination by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Fully automated segmentation, localization, and counting;Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C02494 Imaging study date and time ImgStdyDateTime Date (and time, if applicable and known) the radiologic study was obtained. Date (and time, if applicable and known) the radiologic study was obtained. Date of Imaging Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.). For SCI: The investigation may be carried out at any time after the spinal cord injury. Therefore the date of data collection of the investigation is imperative to be able to identify the data collected in relation to other data collected on the same individual at various time points. In addition, the date is likewise important to have the time interval from date of birth (age), and time interval from date of injury (time since injury).

Duhaime AC, Gean AD, Haacke EM, Hicks R, Wintermark M, Mukherjee P, Brody D, Latour L, Riedy G; Common Data Elements Neuroimaging Working Group Members, Pediatric Working Group Members. Common data elements in radiologic imaging of traumatic brain injury. Arch Phys Med Rehabil. 2010 Nov;91(11):1661-6. [DOI: 10.1016/j.apmr.2010.07.238] Haacke, E.M., Duhaime, A.C., Gean, A.D., Riedy, G., Wintermark, M., Mukherjee, P., Brody, D.L., DeGraba, T., Duncan, T.D., and Elovic, E. (2010). Common data elements in radiologic imaging of traumatic brain injury. Journal of Magnetic Resonance Imaging 32, 516-543, DOI:10.1002/jmri.22259 Biering-SØrensen F, Craggs M, Kennelly M, Schick E, Wyndaele J-J. International urinary tract imaging basic spinal cord injury data set. Spinal Cord 2009;47:379-83. Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C15431 Imaging white matter volume measurement ImgWMVolMeasr Volume of white matter in the brain Volume of white matter in the brain White matter volume Numeric Values

Exploratory for Imaging studies

Answer questions and sub-questions for white matter volume, or white matter volume fraction but not both. Record in mL and use 2 decimal places. Acceptable range is 20.00 - 2000.00.

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

20 2000 milliliter
C17448 Imaging measurement region type ImgMeasrRegnTyp Region of imaging measurement Region of imaging measurement Measurement regions Whole brain;Normal-appearing GM;Normal-appearing WM;Other regional measurements Whole brain;Normal-appearing gray matter;Normal-appearing white matter;Other regional measurements Alphanumeric

Used in both tables for Measurement Regions for Magnetization transfer ratio (MTR) and Diffusion Tensor Imaging (DTI)

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C15364 Imaging juxtacortical lesion count ImgJuxCrtclLesnCt Total number of focal T2-hyperintense brain lesions that are in contact with the cortex (with no intervening white matter) Total number of focal T2-hyperintense brain lesions that are in contact with the cortex (with no intervening white matter) Number of juxtacortical lesions Numeric Values

Expected range 0 - 1000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000
C15462 Imaging spinal cord volume value ImgSpinCordVolVal Volume of the spinal cord Volume/area of the spinal cord Spinal cord measurement Numeric Values

Record in ml and use 2 decimal places.

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

milliliter
C19006 Imaging brain measured structure other text ImgBrainStructureOTH The free-text field related to 'Imaging brain measured structure type' specifying other text. The structure of the brain volume measurement The free-text field related to 'Imaging brain measured structure type' specifying other text. The structure of the brain volume measurement Other, specify Alphanumeric

Exploratory for Imaging studies

Only answered if "Brain structure volume" was answered for "Technique"

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15405 Imaging brain volume fraction value ImgBrainVolFraVal Ratio of whole brain parenchymal volume to total intracranial volume or other head-size normalization volume Ratio of whole brain parenchymal volume to total intracranial volume or other head-size normalization volume Brain volume fraction Numeric Values

Highly recommended for: Imaging studies.

Answer questions and sub-questions for brain volume, or brain volume fraction but not both. Record brain volume fraction. Use 4 decimal places. Acceptable range is 0.5000 - 1.0000.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0.5 1
C15504 Imaging spinal cord volume/cross-sectional area technique type ImgSpnlCrdVolCrsSecAreaTechTyp Method used to determine the cord cross-sectional area or volume as a measure of cord atrophy Method used to determine the cord cross-sectional area or volume as a measure of cord atrophy Technique Used Manual tracing by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Losseff(LOSspin echoFF)-3mmx5 axial slices from C2-3 up;Fully automated segmentation;Other, specify Manual tracing by experienced reader;Semi-automated (calculated through software, verified by experienced reader);Losseff(LOSspin echoFF)-3mmx5 axial slices from C2-3 up;Fully automated segmentation;Other, specify Alphanumeric

Exploratory for Imaging studies

No additional instructions

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C02499 Imaging pulse sequence type ImgPulseSeqTyp Type of imaging pulse sequence used Type of imaging pulse sequence used Image pulse sequence used;Sequence Type T1;T2;FLAIR;DWI;GRE;SWI;DTI;MRSI;PWI;Gradient-echo;Pulsed-ASL;Continuous-ASL;Pseudocontinuous-ASL;Post-contrast FLAIR;Post-contrast T1-weighted;COW MRA;TOF Neck MRA;CE MRA;Other, specify;FLASH;MPRAGE;SPGR;SPACE/VISTA;TSE/FSE;Dual echo PD/T2W SE;PD SE;T2W SE;T1W SE;T1W 3D gradient-echo;T1-weighted spin echo with contrast;T1-weighted spin echo without contrast;PD/T2W FSE;DIR;PSIR;fMRI;PRESS;Spectroscopic imaging 2D;Spectroscopic imaging 3D;Spin echo;STEAM;Single voxel spectroscopy (SVS);Pulsed-ASL;Continuous-ASL;Pseudocontinuous-ASL;Multivoxel spectroscopy;Unlocalized spectroscopy;ISIS;DWI/ADC;rFOV;EPI T1;T2;FLAIR;DWI;GRE;SWI;DTI;MRSI;PWI;Gradient-echo;Pulsed-ASL;Continuous-ASL;Pseudocontinuous-ASL;Post-contrast FLAIR;Post-contrast T1-weighted;COW MRA;TOF Neck MRA;CE MRA;Other, specify;FLASH;MPRAGE;SPGR;SPACE/VISTA;TSE/FSE;Dual echo PD/T2W SE;PD SE;T2W SE;T1W SE;T1W 3D gradient-echo;T1-weighted spin echo with contrast;T1-weighted spin echo without contrast;PD/T2W FSE;DIR;PSIR;fMRI;PRESS;Spectroscopic imaging 2D;Spectroscopic imaging 3D;Spin echo;STEAM;Single voxel spectroscopy (SVS);Pulsed-ASL;Continuous-ASL;Pseudocontinuous-ASL;Multivoxel spectroscopy;Unlocalized spectroscopy;ISIS;DWI/ADC;Reduced field of view (rFOV);Echo Planar Imaging (EPI) Alphanumeric

Exploratory for Imaging studies

In this row, for each column list each pulse sequence checked in question #3 (e.g., MPRAGE, FLAIR, DTI etc.)

No references available Adult;Pediatric Exploratory 3.00 2013-08-28 16:08:00.453 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Multiple Pre-Defined Values Selected

C15433 Imaging brain volume fraction technique type ImgBrainVolFractTechTyp Image analysis method used to calculate whole brain volume fraction Image analysis method used to calculate whole brain volume fraction Technique Used Brain parenchymal fraction (BV/TIV);Brain parenchymal fraction (BV/BOCV);Other, specify Brain parenchymal fraction (BV/TIV);Brain parenchymal fraction (BV/BOCV);Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C18589 Imaging spinal cord area value ImgSpinCordAreaVal Area of the spinal cord Area of the spinal cord Spinal cord measurement Numeric Values

Record in mm2 and use 2 decimal places.

No references available Adult;Pediatric Exploratory 3.00 2013-07-30 14:29:49.047 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

square millimeter
C15367 Imaging cortical lesion count ImgCrtclLesnCt Total number of lesions located in the brain cortex or lesions in the subcortical WM also involving the cortex Total number of lesions located in the brain cortex or lesions in the subcortical WM also involving the cortex Number of cortical lesions Numeric Values

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

C15466 Imaging tissue integrity region type ImgTissueIntegRegTyp The areas of the brain where tissue integrity is measured The areas of the brain where tissue integrity is measured N/A Whole brain;Normal-appearing GM;Normal-appearing WM Whole brain;Normal-appearing GM;Normal-appearing WM Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Single Pre-Defined Value Selected

C19007 Imaging spinal cord lesion technique other text ImgSpinCordLesnTechOTH The free-text field related to 'Imaging spinal cord lesion technique type' specifying other text. Method used to determine the number of lesions located in the spinal cord The free-text field related to 'Imaging spinal cord lesion technique type' specifying other text. Method used to determine the number of lesions located in the spinal cord Other, specify Alphanumeric

Exploratory for Imaging studies

No additional instructions

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

C15407 Imaging ventricular volume measurement ImgVentrclVolMeas Volume measurement of the ventricles Volume measurement of the ventricles Ventricular volume Numeric Values

Answer questions and sub-questions for ventricular volume, or ventricular volume fraction but not both. Record ventricular volume in mL. Use 2 decimal places. Acceptable range is 0.00 - 1000.00.

No references available Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 1000 milliliter
C15506 Imaging spinal cord volume/cross-sectional area slice thickness measurement ImgSpinCordVolArSliThiMeasr Thickness of the spinal cord volume/cross-sectional area optical slice Thickness of the spinal cord volume/cross-sectional area optical slice Slice thickness Numeric Values

Exploratory for Imaging studies

Record value in millimeters (mm)

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

millimeter
C08244 Imaging slice thickness value ImgSliceThicknessVal Value of the thickness of the slice measured in millimeters (mm) Value of the thickness of the optical slice measured in millimeters (mm) Slice thickness Numeric Values

Record value in millimeters (mm). If the sequences are different for T1 and T2 sequence parameters, record the T2 parameters as indicated. If they are the same, leave the T2 parameters section blank. If the sequences are different for T1 and FLAIR sequence parameters, record the FLAIR parameters as indicated. If they are the same, leave the FLAIR parameters section blank. DTI sequence parameters

No references available Adult;Pediatric Supplemental 3.00 2013-07-25 08:54:08.2 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0 99 millimeter
C15434 Imaging white matter volume fraction value ImgWMVolFractVal Ratio of white matter volume to total intracranial volume or other head-size normalization volume Ratio of white matter volume to total intracranial volume or other head-size normalization volume White matter volume fraction Numeric Values

Exploratory for Imaging studies

Answer questions and sub-questions for white matter volume, or white matter volume fraction but not both. Use 4 decimal places when recording volume fraction. Acceptable range is 0.2000 - 0.8000.

No references available Adult;Pediatric Exploratory 3.00 2013-06-11 00:00:00.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations

Free-Form Entry

0.2 0.8
C18694 Imaging diffusion measurement other text ImgDiffusionMeasrOTH The free-text field related to 'Imaging diffusion measurement type' specifying other text. Type of diffusion tensor imaging (DTI) measurement The free-text field related to 'Imaging diffusion measurement type' specifying other text. Type of diffusion tensor imaging (DTI) measurement Other, specify Alphanumeric

No additional instructions

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Imaging Analysis Technique and Results - Baseline Imaging Diagnostics Assessments and Examinations 4000

Free-Form Entry

CSV