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National Institutes of Health (NIH) Toolbox
Please visit this website for more information about the instrument: NIH Toolbox
Supplemental : Amyotrophic Lateral Sclerosis (ALS), Cerebral Palsy (CP), Chiari I Malformation (CM), Congenital Muscular Dystrophy (CMD),Epilepsy, Duchenne/Becker Muscular Dystrophy (DMD), Friedreichs Ataxia (FA), Facioscapulohumeral Muscular Dystrophy (FSHD), Headache, Huntington's Disease (HD), Mitochondrial Disease (Mito), Myasthenia Gravis (MG), Myotonic Muscular Dystrophy (DM), Multiple Sclerosis (MS), Neuromuscular Diseases (NMD), Parkinson's Disease (PD), Spinal Cord Injury (SCI), Spinal Muscular Atrophy (SMA), Stroke, and Traumatic Brain Injury (TBI)
Exploratory: Sport-Related Concussion (SRC) Subacute (after 72 hours to 3 months) and Persistent/Chronic (3 months and greater post concussion)
Short Description of Instrument
Purpose: The National Institutes of Health Toolbox is part of the NIH Blueprint initiative. It seeks to assemble brief, comprehensive assessment tools that will be useful in a variety of settings with a particular emphasis on measuring outcomes in epidemiologic studies and clinical trials across the lifespan.
Overview: The ultimate goal is to help improve communication within and between fields of biomedical research and advance knowledge by using common data elements. The battery will examine various cognitive (episodic memory, language, processing speed, working memory, executive functions, attention), emotional (negative affect, positive affect, stress and coping, social relationships), sensory (vestibular, audition, olfaction, taste, vision) and motor functions (dexterity, strength, locomotion, endurance, balance).
Time: The evaluation will take approximately 1-2 hours to complete.
Other Important Notes: The battery is designed to measure these domains in ages 3 through 85.
Scoring and Psychometric Properties
Scoring: The scoring varies by battery.
Psychometric Properties: The battery has gone through extensive work to identify and pre-test the constructs to be measured. Validation is expected to be completed by the end of 2009 with subsequent norming planned on a very large sample.
Strengths: Multiple measures of executive functioning; subtests can be administered independently.
Weaknesses: Tests can require degree of comfort with technology.
Key References:

Carlozzi NE, Tulsky DS, Wolf TJ, Goodnight S, Heaton RK, Casaletto KB, Wong AWK, Baum CM, Gershon RC, Heinemann AW. Construct validity of the NIH Toolbox Cognition Battery in individuals with stroke. Rehabil Psychol. 2017 Nov;62(4):443-54.
Gershon RC, Cella D, Fox NA, Havlik RJ, Hendrie HC, Wagster MV. Assessment of neurological and behavioural function: the NIH Toolbox. Lancet Neurol. 2010 Feb;9(2):138-9.
Additional References:
Quatrano LA, Cruz TH. Future of outcomes measurement: impact on research in medical rehabilitation and neurologic populations. Arch Phys Med Rehabil. 2011 Oct;92(10 Suppl):S7-11.
Reuben DB, Magasi S, McCreath HE, Bohannon RW, Wang YC, Bubela DJ, Rymer WZ, Beaumont J, Rine RM, Lai JS, Gershon RC. Motor assessment using the NIH Toolbox. Neurology. 2013 Mar 12;80(11 Suppl 3):S65-75.

Weintraub S, Dikmen SS, Heaton RK, Tulsky DS, Zelazo PD, Bauer PJ, Carlozzi NE, Slotkin J, Blitz D, Wallner-Allen K, Fox NA, Beaumont JL, Mungas D, Nowinski CJ, Richler J, Deocampo JA, Anderson JE, Manly JJ, Borosh B, Havlik R, Conway K, Edwards E, Freund L, King JW, Moy C, Witt E, Gershon RC. Cognition assessment using the NIH Toolbox. Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64.


Document last updated March 2024