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Multiple Sclerosis International Quality of Life Questionnaire (MusiQoL)
Please visit this website for more information about the instrument:  Multiple Sclerosis International Quality of Life Questionnaire (MusiQoL)
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Supplemental: Multiple Sclerosis (MS)
Short Description of Instrument
Construct measured: Health related quality of life.
Generic vs. disease specific: disease specific.
Means of administration: Self-Administered.
Intended respondent: Patient.
# of items: 31.
# of subscales and names of sub-scales: 9 – Activity of daily living, Coping, Psychological well-being, Relationships (health-care system), Relationships (family), Relationships (friends), Rejection, Sentimental and sexual life, Symptoms.
# of items per sub-scale: Varies.
Comments/Special Instructions
Scoring: Each domain is scored from 0-100, higher scores indicate higher QoL.
Background: The MusiQOL instrument is a multidimensional HRQOL instrument constructed by an international steering committee comprising neurologists, patients, and health economists. It consists of 31 questions divided into nine dimensions.
Simeoni M, Auquier P, Fernandez O, et al. Validation of the Multiple Sclerosis International Quality of Life questionnaire. Mult Scler.2008; 14(2):219-230.


Document last updated June 2019
Strengths/ Weaknesses: International validation in several languages using the SF-36 as gold standard.
Psychometric Properties: MusiQOL has been validated in 20 countries and 14 languages and in the following forms of MS: relapsing-remitting, secondary progressive, progressive relapsing, and clinically isolated syndrome. The MusiQOL showed high levels of internal consistency, reproducibility, and test-retest reliability. Notable ceiling effects were observed in MS patients on dimensions reported to have ceiling or floor effects in the SF-36 and MSQOL-54, and the MusiQOL is sensitive to change in both patient-reported and physician diagnosed health status. The activity of daily living and psychological well-being dimensions were particularly sensitive to both improvement and worsening in health status.
Administration: Self completion; takes about 10 minutes.