CDE Detailed Report

Disease: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Sub-Domain: Autonomic
CRF: Modified Orthostatic Symptom Grading Scale

Displaying 1 - 20 of 20
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C58333 Fatigue activity interfere scale FatActInterfereScl Scale of fatigue interference with daily living activities Scale of fatigue interference with daily living activities Fatigue activities of daily living 0;1;2;3;4 0 Fatigue does not interfere with activities of daily living (e.g., school, work, chores, dressing, bathing);1 Fatigue mildly interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);2 Fatigue moderately interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);3 Fatigue severely interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);4 I am bed- or wheelchair-bound because of fatigue. (Fatigue severely interferes with activities of daily living (e.g., school, work, chores, dressing, bathing} Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 16:39:29.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58367 Problems thinking and concentrating stand duration scale ProbThnkConctrtStndDurationScl Scale for the duration of standing time before problems with thinking and concentrating occur Scale for the duration of standing time before problems with thinking and concentrating occur Problems thinking and concentrating standing time 0;1;2;3;4 0 On most occasions, I can stand as long as necessary without experiencing any problems thinking and concentrating;1 On most occasions, I can stand more than 15 minutes before experiencing problems thinking and concentrating;2 On most occasions, I can stand 5-14 minutes before experiencing problems thinking and concentrating;3 On most occasions, I can stand for 1-4 minutes before experiencing problems thinking and concentrating;4 On most occasions, I can stand less than 1 minute before experiencing problems thinking and concentrating Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 10:59:30.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58334 Fatigue stand duration scale FatStandDurationScl Scale for the duration of standing time before fatigue occurs Scale for the duration of standing time before fatigue occurs Fatigue standing time 0;1;2;3;4 0 On most occasions, I can stand as long as necessary without experiencing any fatigue;1 On most occasions, I can stand more than 15 minutes before experiencing fatigue;2 On most occasions, I can stand 5-14 minutes before experiencing fatigue;3 On most occasions, I can stand 1-4 minutes before experiencing fatigue;4 On most occasions, I can stand less than 1 minute before experiencing fatigue Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 16:49:14.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58369 Blurry vision frequency scale BlurryVisionFreqScl Frequency of blurry vision scale Frequency of blurry vision scale Blurry vision frequency 0;1;2;3;4 0 I never or rarely experience blurry vision when I stand up;1 I sometimes experience blurry vision when I stand up;2 I often experience blurry vision when I stand up;3 I usually experience blurry vision when I stand up;4 I always experience blurry vision when I stand up Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 11:54:14.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58335 Lightheadedness frequency scale LightheadednessFreqScl Frequency of lightheadedness scale Frequency of lightheadedness scale Lightheadedness frequency 0;1;2;3;4 0 I never or rarely experience lightheadedness when I stand up;1 I sometimes experience lightheadedness when I stand up;2 I often experience lightheadedness when I stand up;3 I usually experience lightheadedness when I stand up;4 I always experience lightheadedness when I stand up Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 16:55:41.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58371 Blurry vision severity scale BlurryVisionSevScl Severity of blurry vision scale Severity of blurry vision scale Blurry vision severity 0;1;2;3;4 0 I never or rarely experience blurry vision when I stand up;1 I experience mild blurry vision when I stand up;2 I experience moderate blurry vision when I stand up and sometimes have to sit back down for relief;3 I experience severe blurry vision when I stand up and frequently have to sit back down for relief;4 I experience severe blurry vision when I stand up and almost always have to sit back down Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 11:58:56.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58336 Severity lightheadedness scale LightheadednessSevScl Severity of lightheadedness scale Severity of lightheadedness scale Lightheadedness severity 0;1;2;3;4 0 I do not experience lightheadedness when I stand up;1 I experience mild lightheadedness when I stand up;2 I experience moderate lightheadedness when I stand up and sometimes have to sit back down for relief;3 I experience severe lightheadedness when I stand up and frequently have to sit back down for relief;4 I experience severe lightheadedness when I stand up and regularly faint if I do not sit back down Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 17:06:42.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58375 Blurry vision occurrence condition scale BlurryVisionOccurCondScl Scale of the frequency of conditions in which blurry vision occurs Scale of the frequency of conditions in which blurry vision occurs Conditions under which blurry vision occurs 0;1;2;3;4 0 I never or rarely experience blurry vision under any circumstances;1 I sometimes experience blurry vision under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);2 I often experience blurry vision under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);3 I usually experience blurry vision under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);4 I always experience blurry vision when I stand up, the specific conditions do not matter Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 12:05:17.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58337 Lightheadedness occurrence condition frequency scale LightOccurCondFreqScl Scale of the frequency of conditions when lightheadedness occurs Scale of the frequency of conditions when lightheadedness occurs conditions under which lightheadedness occurs 0;1;2;3;4 0 I never or rarely experience lightheadedness under any circumstances;1 I sometimes experience lightheadedness under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), when exposed to heat (e.g., hot day, hot bath, hot shower) or getting up too quickly from sitting or lying down;2 I often experience lightheadedness under certain conditions, such as prolonged standing, after a mea, after exertion (e.g., walking), when exposed to heat (e.g., hot day, hot bath, hot shower) or getting up too quickly from sitting or lying down;3 I usually experience lightheadedness under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), when exposed to heat (e.g., hot day, hot bath, hot shower) or getting up too quickly from sitting or lying down;4 I always experience lightheadedness when I stand up, the specific conditions do not matter Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 17:19:58.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58376 Blurry vision activity interference scale BlurryVisionAdlScl Scale of blurry vision interference with daily living activities Scale of blurry vision interference with daily living activities Blurry vision activities of daily living 0;1;2;3;4 0 Blurry vision does not interfere with activities of daily living (e.g., school, work, chores, reading, dressing, bathing);1 Blurry vision mildly interferes with activities of daily living (e.g., school, work, chores, reading, dressing, bathing);2 Blurry vision moderately interferes with activities of daily living (e.g., school, work, chores, reading, dressing, bathing);3 Blurry vision severely interferes with activities of daily living (e.g., school, work, chores, reading, dressing, bathing);4 Blurry vision always interferes with activities of daily living (e.g., school, work, chores, reading, dressing, bathing) Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 12:10:28.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58338 Lightheadedness activity interfere scale LightheadActInterfereScl Scale of lightheadedness interference with daily living activities Scale of lightheadedness interference with daily living activities Lightheadedness activities of daily living 0;1;2;3;4 0 Lightheadedness does not interfere with activities of daily living (e.g., school work, chores, dressing, bathing);1 Lightheadedness mildly interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);2 Lightheadedness moderately interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);3 Lightheadedness severely interferes with activities of daily living (e.g., school, work, chores, dressing, bathing);4 I experience severe lightheadedness when I stand up and regularly faint if I do not sit back down Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 09:00:35.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58379 Blurry vision stand duration scale BlurryVisionStandDurationScl Scale for the duration of standing time before blurry vision occurs Scale for the duration of standing time before blurry vision occurs Blurry vision standing time 0;1;2;3;4 0 On most occasions, I can stand as long as necessary without experiencing any blurry vision;1 On most occasions, I can stand more than 15 minutes before experiencing blurry vision;2 On most occasions, I can stand 5-14 minutes before experiencing blurry vision;3 On most occasions, I can stand 1-4 minutes before experiencing blurry vision;4 On most occasions, I can stand less than 1 minute before experiencing blurry vision Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 12:15:07.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58345 Lightheadedness stand duration scale LightheadStandDurationScl Scale for the duration of standing time before lightheadedness occurs Scale for the duration of standing time before lightheadedness occurs Lightheadedness standing time 0;1;2;3;4 0 On most occasions, I can stand as long as necessary without experiencing any lightheadedness;1 On most occasions, I can stand more than 15 minutes before experiencing lightheadedness;2 On most occasions, I can stand 5-14 minutes before experiencing lightheadedness;3 On most occasions, I can stand 1-4 minutes before experiencing lightheadedness;4 On most occasions, I can stand less than 1 minute before experiencing lightheadedness Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 09:37:48.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58358 Frequency of problems thinking and concentrating scale FreqProbThinkConctrtScl Frequency of problems with thinking and concentrating scale Frequency of problems with thinking and concentrating scale Problems thinking and concentrating frequency 0;1;2;3;4 0 I never or rarely experience problems thinking and concentrating when I stand up;1 I sometimes experience problems thinking and concentrating when I stand up;2 I often experience problems thinking and concentrating when I stand up;3 I usually experience problems thinking and concentrating when I stand up;4 I always experience problems thinking and concentrating when I stand up Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 10:28:24.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58322 Fatigue frequency scale FatFreqScl Scale for the frequency of fatigue Scale for the frequency of fatigue Fatigue frequency 0;1;2;3;4 0 I never or rarely experience fatigue when I stand up;1 I sometimes experience fatigue when I stand up;2 I often experience fatigue when I stand up;3 I usually experience fatigue when I stand up;4 I always experience fatigue when I stand up Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 14:00:28.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58360 Severity of problems thinking and concentrating scale SevProbThinkConctrtScl Severity of problems with thinking and concetrating while standing scale Severity of problems with thinking and concetrating while standing scale Problems thinking and concentrating severity 0;1;2;3;4 0 I do not experience problems thinking and concentrating when I stand up;1 I experience mild problems thinking and concentrating when I stand up;2 I experience moderate problems thinking and concentrating when I stand up and sometimes have to sit back down for relief;3 I experience severe problems thinking and concentrating when I stand up and frequently have to sit back down for relief;4 I experience severe problems thinking and concentrating when I stand up and almost always have to sit back down for relief Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 10:33:26.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58324 Severity fatigue scale FatSevScl Severity of fatigue scale Severity of fatigue scale Fatigue severity 0;1;2;3;4 0 I do not experience fatigue when I stand up;1 I experience mild fatigue when I stand up;2 I experience moderate fatigue when I stand up and sometimes have to sit back down for relief;3 I experience severe fatigue when I stand up and frequently have to sit back down for relief;4 I experience severe fatigue when I stand up and almost always have to sit back down for relief Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 14:24:16.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58364 Problems thinking and concentrating occurrence condition frequency scale ProbThnkConctrtConFreqScl Scale of the frequency of conditions when problems thinking and concentrating occur Scale of the frequency of conditions when problems thinking and concentrating occur Conditions under which problems thinking and concentrating occurs 0;1;2;3;4 0 I never or rarely experience problems thinking and concentrating under any circumstances;1 I sometimes experience problems thinking and concentrating under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);2 I often experience problems thinking and concentrating under certain conditions, such as prolonged standing, after a mea, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);3 I usually experience problems thinking and concentrating under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);4 I always experience problems thinking and concentrating when I stand up, the specific conditions do not matter Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 10:40:08.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58332 Fatigue occurrence condition frequency scale FatOccurCondFreqScl Scale of the frequency of conditions when fatigue occurs Scale of the frequency of conditions when fatigue occurs Conditions under which fatigue occurs 0;1;2;3;4 0 I never or rarely experience fatigue under any circumstances;1 I sometimes experience fatigue under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., a hot day, hot bath, hot shower);2 I often experience fatigue under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);3 I usually experience fatigue under certain conditions, such as prolonged standing, after a meal, after exertion (e.g., walking), or when exposed to heat (e.g., hot day, hot bath, hot shower);4 I always experience fatigue when I stand up, the specific conditions do not matter Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-07 16:26:54.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

C58366 Problems thinking and concentrating activity interference scale ProbThnkConctrtAdlScl Scale of problems with thinking and concentrating interfering with daily living activities Scale of problems with thinking and concentrating interfering with daily living activities Problems thinking and concentrating activities of daily living 0;1;2;3;4 0 Problems thinking and concentrating do not interfere with activities of daily living (e.g., school work, chores, reading);1 Problems thinking and concentrating mildly interfere with activities of daily living (e.g., school, work, chores, reading);2 Problems thinking and concentrating moderately interfere with activities of daily living (e.g., school, work, chores, reading);3 Problems thinking and concentrating severely interfere with activities of daily living (e.g., school, work, chores, reading);4 Problems with thinking and concentrating always interfere with activities of daily living (e.g., school, work, chores, reading) Numeric Values

Please see the Data Dictionary for definitions for each of the data elements included in this CRF Module.

Comment: The Orthostatic Grading Scale CRF is modified from the Orthostatic Grading Scale (Schrezenmaier et. al., 2005), which asks about "orthostatic symptoms". Because respondents with or without ME/CFS might not be familiar with what "orthostatic" symptoms are, the questionnaire has been expanded to ask about four common orthostatic symptoms (fatigue, lightheadedness, problems thinking and concentrating, and blurry vision).

1. Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud-Larson LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clin Proc. 2005 Mar;80(3):330-4 Adult;Pediatric Exploratory 1.00 2018-02-08 10:49:48.0 Modified Orthostatic Symptom Grading Scale Autonomic Assessments and Examinations

Single Pre-Defined Value Selected

CSV