CDE Detailed Report

Disease: Multiple Sclerosis
Sub-Domain: Neuropsychological Testing
CRF: Expanded Disability Status Scale (EDSS)

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CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C14713 Expanded Disability Status Scale (EDSS) - function scale EDSSFunctionScl Using the Expanded Disability Status Scale (EDSS) by Kurtzke, the current disability from disease experienced in terms of level of function of the participant/subject Using the Expanded Disability Status Scale (EDSS) by Kurtzke, the current disability from disease experienced in terms of level of function of the participant/subject Expanded Disability Status Scale (EDSS) 0.0;1.0;1.5;2.0;2.5;3.0;3.5;4.0;4.5;5.0;5.5;6.0;6.5;7.0;7.5;8.0;8.5;9.0;9.5;10.0 Normal neurological exam (all grade 0 in all Functional System (FS) scores*);No disability, minimal signs in one FS* (i.e., grade 1);No disability, minimal signs in more than one FS* (more than 1 FS grade 1);Minimal disability in one FS (one FS grade 2, others 0 or 1);Minimal disability in two FS (two FS grade 2, others 0 or 1);Moderate disability in one FS (one FS grade 3, others 0 or 1) or mild disability in three or four FS (three or four FS grade 2, others 0 or 1) though fully ambulatory;Fully ambulatory but with moderate disability in one FS (one grade 3) and one or two FS grade 2;Fully ambulatory without aid, self-sufficient, up and about some 12 hours a day despite relatively severe disability consisting of one FS grade 4 (others 0 or 1), or combination of lesser grades exceeding limits of previous steps, able to walk without aid or rest some 500 meters;Fully ambulatory without aid, up and about much of the day, able to work a full day, may otherwise have some limitation of full activity or require minimal assistance, characterized by relatively severe disability usually consisting of one FS grade 4 (others or 1) or combinations of lesser grades exceeding limits of previous steps, able to walk without aid or rest some 300 meters;Ambulatory without aid or rest for about 200 meters, disability severe enough to impair full daily activities (e.g., to work a full day without special provisions), (Usual FS equivalents are one grade 5 alone, others 0 or 1, or combinations of lesser grades usually exceeding specifications for step 4.0);Ambulatory without aid for about 100 meters, disability severe enough to preclude full daily activities, (Usual FS equivalents are one grade 5 alone, others 0 or 1, or combination of lesser grades usually exceeding those for step 4.0);Intermittent or unilateral constant assistance (cane, crutch, brace) required to walk about 100 meters with or without resting, (Usual FS equivalents are combinations with more than two FS grade 3+);Constant bilateral assistance (canes, crutches, braces) required to walk about 20 meters without resting, (Usual FS equivalents are combinations with more than two FS grade 3+);Unable to walk beyond approximately 5 meters even with aid, essentially restricted to wheelchair, wheels self in standard wheelchair and transfers alone, up and about in wheelchair some 12 hours a day, (Usual FS equivalents are combinations with more than one FS grade 4+, very rarely pyramidal grade 5 alone);Unable to take more than a few steps, restricted to wheelchair, may need aid in transfer, wheels self but cannot carry on in standard wheelchair a full day, May require motorized wheelchair, (Usual FS equivalents are combinations with more than one FS grade 4+);Essentially restricted to bed or chair or perambulated in wheelchair, but may be out of bed itself much of the day, retains many self-care functions, generally has effective use of arms, (Usual FS equivalents are combinations, generally grade 4+ in several systems);Essentially restricted to bed much of day, has some effective use of arm(s), retains some self-care functions, (Usual FS equivalents are combinations, generally 4+ in several systems);Helpless bed patient, can communicate and eat, (Usual FS equivalents are combinations, mostly grade 4+);Totally helpless bed patient, unable to communicate effectively or eat/swallow, (Usual FS equivalents are combinations, almost all grade 4+);Death due to MS Numeric Values

The EDSS is highly recommended to categorize severity of neurological disability in multiple sclerosis.

Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded Disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444-52. Haber A, LaRocca NG. eds. Minimal Record of Disability for multiple sclerosis. New York: National Multiple Sclerosis Society; 1985. Adult;Pediatric Supplemental 3.00 2013-06-11 00:00:00.0 Expanded Disability Status Scale (EDSS) Neuropsychological Testing Outcomes and End Points

Single Pre-Defined Value Selected

CSV