CDE Detailed Report
Disease: Epilepsy
Subdomain Name: Classification
CRF: Classification of Etiology
Displaying 1 - 8 of 8
Subdomain Name: Classification
CRF: Classification of Etiology
Displaying 1 - 8 of 8
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guidance) | Subdomain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
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| C14427 | Epilepsy etiology secondary type | EpilEtioSecondaryTyp | Secondary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible) | Secondary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible | Secondary Cause | Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other | Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other (e.g., encephalocele, structural abnormality of unknown cause) | Alphanumeric |
If more than one specific etiology is selected, specify: If more than one etiology has been coded as definite or possible, then a secondary cause must be selected. Choose the letter corresponding to the etiology for the secondary cause (e.g., b would be chosen if the secondary cause was traumatic brain injury). |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2012-10-05 00:00:00.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C58580 | Specific epilepsy etiology classification type | SpecEpilepsyEtioClassTyp | The categorization for etiology of epilepsy as linked to identified genetic or presumed genetic, structural, metabolic, immune, infectious or unknown causes. Genetic (or presumed) causes of epilepsy are understood to be the direct result of a known or presumed genetic defect(s) in which seizures are the core symptom of the disorder. Unknown cause is meant to be taken neutrally and to designate that the nature of the underlying cause is not yet unknown. Structural, metabolic, immune or infectious causes are due to a distinct condition that has been associated with substantially increased risk of developing epilepsy as demonstrated in appropriately designed studies | The categorization for etiology of epilepsy as linked to identified genetic or presumed genetic, structural, metabolic, immune, infectious or unknown causes. Genetic (or presumed) causes of epilepsy are understood to be the direct result of a known or pre | Specific Etiology | Genetic or presumed genetic;Structural;Metabolic/toxic;Other | Genetic or presumed genetic;Structural;Metabolic/toxic;Other | Alphanumeric |
No instructions available. |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, MoshÉ SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x | Adult;Pediatric | Core | 1.00 | 2018-10-09 15:20:37.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C58582 | Genetic presumed genetic epilepsy etiology type | GeneticPresumeGenEpilEtioTyp | The categorization for genetic or presumed genetic etiology of epilepsy | The categorization for genetic or presumed genetic etiology of epilepsy | Genetic or presumed genetic | Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified | Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified | Alphanumeric |
If genetic or presumed genetic etiology, specify type. Etiologies that are both genetic and structural will be captured under genetic, not otherwise specified |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, MoshÉ SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2018-10-10 08:51:10.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C58587 | Structural epilepsy etiology type | StructuralEpilEtioTyp | The categorization for structural etiology of epilepsy | The categorization for structural etiology of epilepsy | Structural | Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Dementia;Other degenerative neurologic diseases;Mesial Temporal Sclerosis;Structural, other | Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Inborn errors of metabolism;Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Dementia;Other degenerative neurologic diseases;Mesial Temporal Sclerosis;Structural, other (e.g., encephalocele, structural abnormality of unknown cause) | Alphanumeric |
If structural etiology, select the specific type. Etiologies that are both genetic and structural will be captured under genetic, not otherwise specified |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, MoshÉ SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2018-10-10 11:34:22.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C58605 | Metabolic toxic epilepsy etiology type | MetabolToxicEpilEtioTyp | The categorization for metabolic toxic etiology of epilepsy | The categorization for metabolic toxic etiology of epilepsy | Metabolic/toxic | Inborn errors of metabolism;Other metabolic or toxic insults | Inborn errors of metabolism;Other metabolic or toxic insults | Alphanumeric |
If metabolic toxic etiology, select the specific type. |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, MoshÉ SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2018-10-10 15:40:18.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C58606 | Other epilepsy etiology type | OtherEpilEtioTyp | The categorization for other etiology of epilepsy | The categorization for other etiology of epilepsy | Other | Immune;Infectious;Unknown | Immune;Infectious(viral, bacterial, parasitic);Unknown (epilepsy of unknown cause, without relevant abnormalities on examination, coginition, history or imaging) | Alphanumeric |
If other etiology, select the specific type. |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, MoshÉ SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2018-10-10 15:50:51.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C14425 | Epilepsy etiology specific attribution confidence type | EpilepsyEtioSpecAttrbConfidTyp | The level of confidence attributed to the categorizing of specific etiology of epilepsy to genetic or presumed genetic, structural, metabolic, immune, infectious or unknown factors | The level of confidence attributed to the categorizing of specific etiology of epilepsy to genetic or presumed genetic, structural, metabolic, immune, infectious or unknown factor | Present? | No;Possible;Probable;Definite;Unknown;N/A | No;Possible;Probable;Definite;Unknown;N/A | Alphanumeric |
If more than one etiology is present, please identify each plausible etiology (e.g., patient had a traumatic brain injury with loss of consciousness, but also had a known CNS abscess If one etiology could be considered as fitting in two different categories, please check boxes for BOTH categories. Examples include 1) Tuberous Sclerosis Complex, which is both structural and genetic and 2) Glut-1 deficiency which is both metabolic and genetic No = Not present; Possible = The summary of evidence suggests less than 50% confidence level; Probable = the summary of evidence sugests greater than 50% confidence level; Definite = The summary of evidence suggests 100% confidence level; Unknown = The summary of evidence is not suffiecient to support a finding; N/A = Not Applicable; to be used at the discretion fo the Principal Investigator based on study design. |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm | Adult;Pediatric | Supplemental-Highly Recommended | 3.00 | 2013-08-28 16:08:00.453 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
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| C14426 | Epilepsy etiology primary type | EpilEtioPrimryTyp | Primary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible) | Primary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible | Primary Cause | Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other | Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other (e.g., encephalocele, structural abnormality of unknown cause) | Alphanumeric |
If more than one specific etiology is selected, specify: If more than one etiology has been coded as definite or possible, then a primary cause must be selected. Choose the letter corresponding to the etiology for the primary cause (e.g., c would be chosen if the primary cause was stroke). |
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm | Adult;Pediatric | Supplemental-Highly Recommended | 1.00 | 2012-10-05 00:00:00.0 | Classification of Etiology | Classification | Disease/Injury Related Events |
Single Pre-Defined Value Selected |
