CDE Detailed Report

Disease: Parkinson's Disease
Sub-Domain: Other Non-Motor
CRF: Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS)

Displaying 51 - 100 of 100
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C10148 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - sex problem severity score NMSSSexProbSevScore The severity of the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have problems having sex? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10084 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - restlessness leg frequency severity value NMSSRstlssLegFreqSevVal The value of the frequency multiplied by severity for the participant/subject experiencing an urge to move the legs or restlessness in legs that improves with movement when he/she is sitting or lying down inactive as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency multiplied by severity the subject experiences an urge to move the legs or is restless in legs that improves with movement when inactive as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience an urge to move the legs or restlessness in legs that improves with movement when he she is sitting or lying down inactive? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10116 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - problem concentration activity frequency NMSSProbConcenActFreq The frequency of the participant/subject having problems sustaining concentration during activities (for example, reading or having a conversation) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having problems sustaining concentration during activities (for example, reading or having a conversation) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have problems sustaining concentration during activities? For example reading or having a conversation. 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10159 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - change weight frequency NMSSChangWgtFreq The frequency of the participant/subject reporting a recent change in weight (not related to dieting) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject reporting a recent change in weight (not related to dieting) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient report a recent change in weight not related to dieting? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10095 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - feel sad severity score NMSSFeelSadSevScore The severity of the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient seem sad or depressed or has he she reported such feelings? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10127 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - dribble saliva frequency severity value NMSSDribSalivaFreqSevVal The value of the frequency multiplied by severity for the participant/subject dribbling saliva during the day as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject dribbling saliva during the day as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient dribble saliva during the day? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10074 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - doze frequency NMSSDozeFreq The frequency of the participant/subject dozing off or falling asleep unintentionally during daytime activities. For example, during conversation, during mealtimes, or while watching television or reading as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the subject dozing off or falling asleep unintentionally during daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient doze off or fall asleep unintentionally during daytime activities? For example during conversations during mealtimes or while watching television or reading. 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10106 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - see thing not there frequency NMSSSeeThngNotThereFreq The frequency of the participant/subject indicating that he/she sees things that are not there as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject indicating that he/she sees things that are not there as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient indicate that he she sees things that are not there? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10138 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - void severity score NMSSVoidSevScore The severity of the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have to void within two hours of last voiding? Frequency 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10149 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - sex problem frequency NMSSSexProbFreq The frequency of the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have problems having sex? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10085 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - sleep fatigue total score NMSSSleepFatgTotalScore The total score for Domain 2: Sleep/fatigue as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The total score for Domain 2: Sleep/fatigue as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Score Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10117 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - problem concentration activity frequency severity value NMSSProbConcenActFreqSevVal The value of the frequency multiplied by severity for the participant/subject having problems sustaining concentration during activities (for example, reading or having a conversation) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the subject having problems sustaining concentration during activities (for example, reading or having a conversation) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have problems sustaining concentration during activities? For example reading or having a conversation. Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10160 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - change weight frequency severity value NMSSChangWgtFreqSevVal The value of the frequency multiplied by severity for the participant/subject reporting a recent change in weight (not related to dieting) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject reporting a recent change in weight (not related to dieting) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient report a recent change in weight not related to dieting? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10096 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - feel sad frequency NMSSFeelSadFreq The frequency of the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient seem sad or depressed or has he she reported such feelings? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10128 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - difficulty swallow severity score NMSSDfcltySwllwSevScore The severity of the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have difficulty swallowing? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10075 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - doze frequency severity value NMSSDozeFreqSevVal The value of the frequency multiplied by severity for the participant/subject dozing off or falling asleep unintentionally during daytime activities. For example, during conversation, during mealtimes, or while watching television or reading as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the subject dozing off or falling asleep unintentionally during daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient doze off or fall asleep unintentionally during daytime activities? For example during conversations during mealtimes or while watching television or reading. Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10107 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - see thing not there frequency severity value NMSSSeeThngNotThereFreqSevVal The value of the frequency multiplied by severity for the participant/subject indicating that he/she sees things that are not there as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency multiplied by severity for subject indicating that s/he sees things that are not there, as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient indicate that he she sees things that are not there? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10139 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - void frequency NMSSVoidFreq The frequency of the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have to void within two hours of last voiding? Frequency 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10150 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - sex problem frequency severity value NMSSSexProbFreqSevVal The value of the frequency multiplied by severity for the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject having problems having sex as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have problems having sex? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10086 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - lost interest surrounding severity score NMSSLostIntrstSurrndSevScore The severity of the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Has the patient lost interest in his her surroundings 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10118 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - forget event severity score NMSSFrgetEvntSevScore The severity of the participant/subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease. Does the patient forget things that he she has been told a short time ago or events that happened in the last few days? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10161 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - excess sweat severity score NMSSExcsSweatSevScore The severity of the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience excessive sweating not related to hot weather? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10097 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - feel sad frequency severity value NMSSFeelSadFreqSevVal The value of the frequency multiplied by severity for the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject being sad or depressed or has reported such feelings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient seem sad or depressed or has he she reported such feelings? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10129 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - difficulty swallow frequency NMSSDfcltySwllwFreq The frequency of the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have difficulty swallowing? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10076 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - fatigue limit activity severity score NMSSFatgLmtActSevScore The severity of fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does fatigue tiredness or lack of energy not slowness limit the patient's daytime activities? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10108 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - belief not true severity score NMSSBelfNotTrueSevScore The severity of the participant/subject having beliefs that you know are not true. For example, about being harmed, being robbed or being unfaithful as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having beliefs that you know are not true. For example, about being harmed, being robbed or being unfaithful as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have beliefs that you know are not true? For example about being harmed being robbed or being unfaithful? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10140 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - void frequency severity value NMSSVoidFreqSevVal The value of the frequency multiplied by severity for the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease The value of the frequency multiplied by severity for the participant/subject having to void within 2 hours of last voiding (frequency) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have to void within two hours of last voiding? Frequency Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10151 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - sex function total score NMSSSexFuncTotalScore The total score for Domain 8: Sexual function as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The total score for Domain 8: Sexual function as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Score Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

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C10087 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - lost interest frequency NMSSLostIntrstFreq The frequency of the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Has the patient lost interest in his her surroundings 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10119 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - forget event frequency NMSSFrgetEvntFreq The frequency of the participant/subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient forget things that he she has been told a short time ago or events that happened in the last few days? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10066 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - dizziness severity score NMSSDzySevScore The severity of the participant/subject experiencing light-headedness, dizziness, weakness on standing from sitting or lying position as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject experiencing light-headedness, dizziness, weakness on standing from sitting or lying position as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience light-headedness dizziness weakness on standing from sitting or lying position? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10162 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - excess sweat frequency NMSSExcsSweatFreq The frequency of the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience excessive sweating not related to hot weather? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10098 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - flat mood severity score NMSSFlatMoodSevScore The severity of the participant/subject having flat moods without the normal "highs" and "lows" as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having flat moods without the normal "highs" and "lows" as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have flat moods without the normal highs and lows? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10130 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - difficulty swallow frequency severity value NMSSDfcltySwllwFreqSevVal The value of the frequency multiplied by severity for the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject having difficulty swallowing as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have difficulty swallowing? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10077 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - fatigue limit activity frequency NMSSFatgLmtActFreq The frequency of fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does fatigue tiredness or lack of energy not slowness limit the patient's daytime activities? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10109 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - belief not true frequency NMSSBelfNotTrueFreq The frequency of the participant/subject having beliefs that you know are not true. For example, about being harmed, being robbed or being unfaithful as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having beliefs that you know are not true. For example, about being harmed, being robbed or being unfaithful as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have beliefs that you know are not true? For example about being harmed being robbed or being unfaithful? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10141 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - night urine severity score NMSSNightUrnSevScore The severity of the participant/subject having to get up regularly at night to pass urine. (nocturia) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject having to get up regularly at night to pass urine. (nocturia) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have to get up regularly at night to pass urine? Nocturia 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10152 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - pain severity score NMSSPainSevScore The severity of the participant/subject suffering from pain not explained by other known conditions. Related to intake of drugs and is relieved by antiparkinson drugs as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject suffering from pain not explained by other known conditions. Related to intake of drugs and is relieved by antiparkinson drugs as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient suffer from pain not explained by other known conditions? Is it related to intake of drugs and is it relieved by antiparkinson drugs? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10088 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - lost interest frequency severity value NMSSLostIntrstFreqSevVal The value of the frequency multiplied by severity for the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease. The value of the frequency multiplied by severity for the participant/subject losing interest in his/her surroundings as part of the Non-Motor Symptom assessment scale for Parkinson's Disease. Has the patient lost interest in his her surroundings Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10120 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - forget event frequency severity value NMSSFrgetEvntFreqSevVal The value of the frequency multiplied by severity for the participant/subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the subject forgetting things that he/she has been told a short time ago or events that happened in the last few days as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient forget things that he she has been told a short time ago or events that happened in the last few days? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10067 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - dizziness frequency NMSSDzyFreq The frequency of the participant/subject experiencing light-headedness, dizziness, weakness on standing from sitting or lying position as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject experiencing light-headedness, dizziness, weakness on standing from sitting or lying position as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience light-headedness dizziness weakness on standing from sitting or lying position? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10163 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - excess sweat frequency severity value NMSSExcsSweatFreqSevVal The value of the frequency multiplied by severity for the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject experiencing excessive sweating (not related to hot weather) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient experience excessive sweating not related to hot weather? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10099 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - flat mood frequency NMSSFlatMoodFreq The frequency of the participant/subject having flat moods without the normal "highs" and "lows" as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having flat moods without the normal "highs" and "lows" as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have flat moods without the normal highs and lows? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10131 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - suffer constipation severity score NMSSSffrConstptnSevScore The severity of the participant/subject suffering from constipation (bowel action less than 3 times weekly) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant/subject suffering from constipation (bowel action less than 3 times weekly) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient suffer from constipation? Bowel action less than three times weekly. 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10142 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - night urine frequency NMSSNightUrnFreq The frequency of the participant/subject having to get up regularly at night to pass urine. (nocturia) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject having to get up regularly at night to pass urine. (nocturia) as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have to get up regularly at night to pass urine? Nocturia 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10078 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - fatigue limit activity frequency severity value NMSSFatgLmtActFreqSevVal The value of the frequency multiplied by severity for the fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the fatigue (tiredness) or lack of energy (not slowness) that limits the participant/subject daytime activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does fatigue tiredness or lack of energy not slowness limit the patient's daytime activities? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10110 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - belief not true frequency severity value NMSSBelfNotTrueFreqSevVal The value of the frequency multiplied by severity for the participant/subject having beliefs that you know are not true. For example, about being harmed, being robbed or being unfaithful as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The value of the frequency multiplied by severity for the participant/subject having beliefs that you know are not true, as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient have beliefs that you know are not true? For example about being harmed being robbed or being unfaithful? Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Free-Form Entry

C10153 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - pain frequency NMSSPainFreq The frequency of the participant/subject suffering from pain not explained by other known conditions. Related to intake of drugs and is relieved by antiparkinson drugs as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The frequency of the participant/subject suffering from pain not explained by other known conditions. Related to intake of drugs and is relieved by antiparkinson drugs as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient suffer from pain not explained by other known conditions? Is it related to intake of drugs and is it relieved by antiparkinson drugs? 1;2;3;4 rarely (<1/wk);often (1/wk);frequent (several times per week);very frequent (daily or all the time) Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10089 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - lost interest activity severity score NMSSLostIntrstActSevScore The severity of the participant/subject losing interest in doing things or lacking motivation to start new activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease. The severity of the participant/subject losing interest in doing things or lacking motivation to start new activities as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Has the patient lost interest in doing things or lack motivation to start new activities? 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

C10121 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) - forget do thing severity score NMSSFrgetDoThngSevScore The severity of the participant forgetting to do things. For example, take tablets or turn off domestic appliances as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). The severity of the participant forgetting to do things. For example, take tablets or turn off domestic appliances as part of the Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS). Does the patient forget to do things? For example take tablets or turn off domestic appliances. 0;1;2;3 None;mild: symptoms present but causes little distress or disturbance to patient;moderate: some distress or disturbance to patient;severe: major source of distress or disturbance to patient Numeric Values Martinex-Martin P, Rodriguez-Blazquez C, Bhattacharya KB, et al. International Study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson Disease. Neurology 2009; 73:1584-1591. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Non-Motor Symptom assessment scale for Parkinson's Disease (NMSS) Other Non-Motor Outcomes and End Points

Single Pre-Defined Value Selected

CSV