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Composite Autonomic Severity Scale (CASS)
Composite Autonomic Severity Scale (CASS)
| Availability |
Please email the author for information about obtaining the instrument: low@mayo.edu
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| Classification |
Supplemental: Parkinson's Disease (PD)
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| Short Description of Instrument |
The Composite Autonomic Scoring Scale (CASS) is a 10-point scoring system of autonomic function. The scale rates adrenergic deficits by one of four grades, and sudomotor and cardiovagal deficits each by one of three grades. |
| Scoring |
Each score is normalized for the compounding effects of age and sex. The score ranges from 0 (no deficit) to 10 (maximal deficit).
Patients with a score of 3 or less have only mild autonomic failure, patients scoring 7–10 have severe autonomic failure and patients scoring 0–2 have moderate autonomic failure.
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| References |
Cohen J, Low P, Fealey R, et al. Somatic and autonomic function in progressive autonomic failure and multiple systems atrophy. Ann Neurol 1987; 22: 692-699.
Low PA. Composite autonomic scores scale for laboratory quantification of generalized autonomic failure. Mayo Clin Proc 1993; 68: 748-752.
Low PA. Laboratory evaluation of autonomic dysfunction, In: Low PA, ed. Clinical autonomic disorders: evaluation and management. 2nd ed. Philadelphia: Lippincott-Raven, 1997: 179-208.
Document last updated April 2020
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