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Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC)
Please visit this website for more information about the instrument: Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change.
Supplemental: Parkinson's Disease (PD)
Short Description of Instrument
Construct measured: A means whereby the clinician can address clinically relevant change (global measure).
Means of administration: Organized but unstructured clinical interview with patient and caregiver.
Intended respondent: patient & caregiver.
Comprises two parts (I & II). Part I is baseline evaluation (information from both subject and informant). Part II has forms for both subject and informant.
Part 1 records baseline information and serves as a reference for future ratings. Part II uses informant and subject derived information, obtained separately, from which an impression of change score is made.
At baseline:
Parts I and II share a similar format with columns headed "Area" (various areas that might be evaluated for potential change) and "Probes" (sample items that the clinician might find helpful in assessing an area). A third column provides space for taking notes.
At follow up:
Part II is administered, with order of interview (subject or informant) kept consistent throughout. The clinician may refer to baseline data to enable a change on the Likert scale (see below) to be completed. The clinician alone must make decisions regarding change, and not consult other staff.
Seven-point categorical scale that gives a global rating of change in symptoms from a baseline level. The instrument can reflect change in several domains (e.g. cognition, attention and wakefulness, psychiatric symptoms). A score of:
1 = substantial improvement. 2 = moderate improvement. 3 = minimum improvement. 4 = no change. 5 = minimum worsening. 6 = moderate worsening. 7 = substantial worsening.
Schneider LS, Olin JT, Doody RS, et al. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11:S22-32.


Document last updated April 2020