CDE Detailed Report

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CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C12026 Written Verbal Fluency Test (WVFT) - write four letter C word four minute count WVFTWrite4LtrCWord4MinCt Count of legitimate words exactly 4 letters long and beginning with the letter C that the participant/subject was able to write in 4 minutes Count of legitimate words exactly 4 letters long and beginning with the letter C that the participant/subject was able to write in 4 minutes Scoring Numeric Values

Write as many words consisting of four letters only beginning with the letter C in four minutes.

Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grise D, Goldstein LH. Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia 38(2000):734-747. Abrahams, S., Goldstein, LH., Al-Chalabi, A., Pickering, A., Morris, RG., Passingham, RE., Brooks, DJ. and Leigh PN. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62, 464-472. Abrahams, S., Goldstein, L.H., Simmons, A., Brammer, M. J., Williams, S. C. R. Giampietro, V. and Leigh, P.N (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127, 1507 - 1517. Abrahams, S., Goldstein, L.H., Suckling, J., Ng, V., Simmons, A., Giampietro, V. Atkins, L., Williams, S.C.R. and Leigh, P.N.. (2005a) Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology. 252, 321-331. Abrahams, S., Goldstein, L.H. and Leigh, P.N. (2005b) Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64 1222-1226 Adult;Pediatric Exploratory 3.00 2013-07-22 16:57:17.79 Written Verbal Fluency Test [php] [php_1]

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C12027 Written Verbal Fluency Test (WVFT) - copy previous word rapid text WVFTCopyPrevWordRapidTxt Text of previously generated words copied by the participant/subject as fast as possible as part of Written Verbal Fluency Test Text of previously generated words copied by the participant/subject as fast as possible as part of Written Verbal Fluency Test The participant/subject copies the words previously generated as fast as possible Alphanumeric

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Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26. Adult;Pediatric Exploratory 3.00 2013-07-22 16:57:17.79 Written Verbal Fluency Test [php] [php_1] 255

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C12028 Written Verbal Fluency Test (WVFT) - copy word fast possible duration WVFTCopyWordFastPossDur Duration required by the participant/subject to copy the legitimate words from both the intial-S list and the 4-letter initial-C list as fast as possible Duration required by the participant/subject to copy the legitimate words from both the initial-S list and the 4-letter initial-C list as fast as possible Scoring Numeric Values

Following a delay (which reduces fatigue), the patient is timed as they copy the words they previously generated as fast as possible.

Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26. Adult;Pediatric Exploratory 3.00 2013-07-22 16:57:17.79 Written Verbal Fluency Test [php] [php_1]

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C12029 Written Verbal Fluency Test (WVFT) - index value WVFTIndexVal Value of the Written Verbal Fluency Index, calculated by subtracting the time taken to copy the words from 9 minutes, then dividing the resulting time by the number of legitimate words Value of the Written Verbal Fluency Index, calculated by subtracting the time taken to copy the words from 9 minutes, then dividing the resulting time by the number of legitimate words Scoring Numeric Values

The patient is timed as they copy the words they previously generated as fast as possible, from which a Written Verbal Fluency Index is calculated. This consists of an estimate of the average time to 'think' of each word [(the time allowed for the test: 9 minutes minus the time taken to copy the words], divided by the total number of correct words].

Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26. Adult;Pediatric Exploratory 3.00 2013-07-22 16:57:17.79 Written Verbal Fluency Test [php] [php_1]

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C12025 Written Verbal Fluency Test (WVFT) - write letter S word five minute count WVFTWriteLtrSWord5MinCt Count of legitimate words beginning with the letter S written by the participant/subject in 5 minutes Count of legitimate words beginning with the letter S written by the participant/subject in 5 minutes Scoring Numeric Values

Write as many words as possible beginning with the letter S in 5 minutes.

Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26. Adult;Pediatric Exploratory 3.00 2013-07-22 16:57:17.79 Written Verbal Fluency Test [php] [php_1]

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