CDE Detailed Report
Disease: Spinal Muscular Atrophy
Subdomain Name: Laboratory Tests and Biospecimens/Biomarkers
CRF: Muscle Biopsy and Autopsy Tissue
Displaying 51 - 68 of 68
Subdomain Name: Laboratory Tests and Biospecimens/Biomarkers
CRF: Muscle Biopsy and Autopsy Tissue
Displaying 51 - 68 of 68
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guideline) | Subdomain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C17898 | Laboratory director unknown indicator | LabDirectorUnknownInd | Indicator of unknown laboratory director | Indicator of unknown laboratory director | Name of laboratory director | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12258 | Biopsy and autopsy central cores type | BpApCentrlCoreTyp | The composition of the central cores | The composition of the central core | Central cores, Specify | Structured;Unstructured | Structured;Unstructured | Alphanumeric |
Only answered if "Central cores" is answered for "Myopathy-associated pathological structures" |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12232 | Laboratory director name | LabDirectorName | Name of laboratory director where assessment was performed | Name of laboratory director where assessment was performed | Name of laboratory director | Alphanumeric |
No instructions available |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
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| C12269 | Biopsy and autopsy immunohistochemical immunofluorescence assays performed | BpApImnhschmImnflrsncAssyPerf | List of stains used | List of stains used | Immunohistochemical/ Immunofluorescence assays performed | Alphanumeric |
List the stains used based upon answers in question 3 |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
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| C12247 | Biopsy and Autopsy tissue collection method type | BpApTissCollMethdTyp | The type of method used for collection of the tissue specimen | The type of method used for collection of the tissue specimen | Biopsy method | Punch biopsy;Blister biopsy;Open biopsy;Open;Needle | Punch biopsy;Blister biopsy;Open biopsy;Open;Needle | Alphanumeric |
No instructions available |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12520 | Specimen type 1 fiber muscle biopsy percent result number | SpecTyp1FibMuscBpPctResltNum | Result for type 1 fiber muscle biopsy percent | Result for type 1 fiber muscle biopsy percent | Numeric Values |
Only record Type 1 fiber percentage if Type 1 predominance is completed |
No references available | Adult | Supplemental | 3.00 | 2013-07-25 08:54:08.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Free-Form Entry |
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| C17899 | Preservation technique not used indicator | PreservTechNotUseInd | Indicates preservation technique used is not known | Indicates preservation technique used is not known | Freezing or Fixation Used? | Yes;No:Unknown | Yes;No:Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12259 | Biopsy and autopsy inflammation type | BpApInflamTyp | Perivascular inflammation is focused around blood vessels, whereas diffuse inflammation also spreads across the muscle tissue. Inflammatory cells identified include lymphocytes, neutrophils, macrophages, and eosinophils. At times, microorganisms can be identified and should be mentioned | Perivascular inflammation is focused around blood vessels, whereas diffuse inflammation also spreads across the muscle tissue. Inflammatory cells identified include lymphocytes, neutrophils, macrophages, and eosinophils. At times, microorganisms can be identified and should be mentione | Specify | Perivascular;Diffuse;Associated with myofiber damage;Inflammatory cells identified;Microorganisms identified | Perivascular;Diffuse;Associated with myofiber damage;Inflammatory cells identified;Microorganisms identified | Alphanumeric |
Only answered if "Inflammation" is answered for "Which of the following diagnostic abnormalities were noted on histochemical stains?" |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12233 | Preservation technique used type | PresrvtnTechnqUseTyp | Type of preservation technique used to preserve the specimen | Type of preservation technique used to preserve the specimen | Freezing or Fixation Used? | Frozen;Formalin-fixed;Paraffin-embedded;Epon-embedded | Frozen;Formalin-fixed;Paraffin-embedded;Epon-embedded | Alphanumeric |
No instructions available |
No references available | Adult;Pediatric | Core | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12270 | Biopsy and autopsy antibodies used name | BpApAntibodUseName | List the names of antibodies used | List the names of antibodies used | Name of antibodies used | Alphanumeric |
If names of antibodies used is not known, select Not known. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
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| C12248 | Pathologist name | PathologistName | Name of pathologist who diagnosed the case | Name of pathologist who diagnosed the case | Name of pathologist who diagnosed the case | Alphanumeric |
No instructions available |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
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| C12521 | Specimen type 2 fiber muscle biopsy percent result number | SpecTyp2FibMuscBiopPctResltNum | Result for type 2 fiber muscle biopsy percent | Result for type 2 fiber muscle biopsy percent | Numeric Values |
Only record Type 2 fiber percentage if Type 2 predominance is completed |
No references available | Adult | Supplemental | 3.00 | 2013-07-25 08:54:08.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Free-Form Entry |
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| C17900 | Age presentation year value | AgePresentYearVal | Age (in years) of participant/subject at presentation | Age (in years) of participant/subject at presentation | Age at presentation | Numeric Values | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Free-Form Entry |
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| C12260 | Biopsy and autopsy perivascular inflammation type | BpApPerivasInflamTyp | Evidence of vascular damage includes damaged vessels in association with perivascular inflammation and the presence of fibrin thrombi located within vascular spaces | Evidence of vascular damage includes damaged vessels in association with perivascular inflammation and the presence of fibrin thrombi located within vascular space | Perivascular, Specify | Evidence of vascular damage;Thrombi identified in blood vessels | Evidence of vascular damage;Thrombi identified in blood vessels | Alphanumeric |
Only answered if "Perivascular" is answered for "Inflammation" |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C12234 | Preservation technique used amount value | PresrvtnTechnqUseAmntVal | Value of the amount of preservation solution or material used to preserve the specimen | Value of the amount of preservation solution or material used to preserve the specimen | Amount | Alphanumeric |
Answer for the freezing or fixation technique used. Answer should be recorded in milligrams (mg). If amount used is not known, select Not known. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
milligram | ||||||||
| C12271 | Western Blot assay performed name | WstBlotAssyPerfName | Name(s) of the assay performed | Name(s) of the assay performed | List the Western Blot assays performed and corresponding results | Alphanumeric |
No instructions available |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations | 255 |
Free-Form Entry |
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| C12249 | Biopsy and Autopsy histochemical stains diagnostic abnormalities present type | BpApHschmStnDiagnAbnrmlyPrsTyp | The diagnostic abnormalities present on the histochenmical stains for the participant's/subject's tissue | The diagnostic abnormalities present on the histochemical stains for the participant's/subject's tissue | Which of the following diagnostic abnormalities were noted on histochemical stains? | Fatty replacement;Endomysial fibrosis;Myofiber degeneration;Myofiber regeneration;Abnormalities of fiber type;Hypertrophic fibers;Atrophy/Hypotrophy;Myopathy-associated pathological structures;Inflammation;Abnormal storage material | Fatty replacement;Endomysial fibrosis;Myofiber degeneration;Myofiber regeneration;Abnormalities of fiber type;Hypertrophic fibers;Atrophy/Hypotrophy;Myopathy-associated pathological structures;Inflammation;Abnormal storage material | Alphanumeric |
Choose all that apply |
No references available | Adult;Pediatric | Core | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C12524 | Inflammation severity status | InflamSeverStat | Severity of Inflammation muscle diagnostic abnormalities | Severity of Inflammation muscle diagnostic abnormalities | Inflammation | Mild;Moderate;Severe | Mild;Moderate;Severe | Alphanumeric |
No instructions available |
No references available | Adult | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Muscle Biopsy and Autopsy Tissue | Laboratory Tests and Biospecimens/Biomarkers | Assessments and Examinations |
Single Pre-Defined Value Selected |
