CDE Detailed Report

Disease: content
Subdomain Name: Classification
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Displaying 51 - 88 of 88
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C14225 Trial of ORG 10172 in Acute Stroke Treatment (TOAST) - ischemic stroke sub type TOASTIschemStrokSubTyp Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System Identify the Ischemic Stroke Subtype based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification System. Large artery atherosclerosis;Cardioembolism;Stroke of other determined etiology;Stroke of undetermined etiology;Small artery occlusion Atherosclerotic lesion causing greater than 50% stenosis;Divided into high-risk and medium-risk sources based on their relative potential to cause stroke;Rare causes such as non-atherosclerotic vasculopathies, hematologic disorders, or hypercoagulable states;Including, a. Two or more causes, b. Negative evaluation (unknown), c. Incomplete evaluation;Lacunar syndrome with or without evidence of ischemic lesion less than 1.5 cm in diameter in the brain stem or subcortical white matter Alphanumeric

Choose one.

Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C19077 Sophia imaging stroke composite diagnosis method other text SophiaImgStrkCompDiaMthdOthTxt The free-text field related to 'Imaging stroke composite diagnosis method type' specifying other text. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification The free-text field related to 'Imaging stroke composite diagnosis method type' specifying other text. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context Other, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C14238 Intraventricular hemorrhage presumed cause type IVHPresumedCauseTyp Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowed Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowe Indicate the presumed cause(s) of the intraventricular hemorrhage (IVH). Hypertensive;Tumor;Anti-coagulant related IVH;Arteriovenous malformation;Other, specify (list);Undetermined Hypertensive ICH is defined as an IVH in the setting of known history of hypertension without another defined structural cause.;Tumor;Anti-coagulant related IVH;Arteriovenous malformation;Other, specify (list);Undetermined Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14254 Subarachnoid hemorrhage quadrigeminal cistern score SubarachHemQuadCisScore SAH Volume Scale (Hijdra) - Quadrigeminal cistern score SAH Volume Scale (Hijdra) - Quadrigeminal cistern score Quadrigeminal cistern score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13831 Graeb intraventricular hemorrhage (IVH) scale - right lateral ventricle score GraebIVHScaleRightLatVentScore Indicates Graeb IVH Scale - Right lateral ventricle score Indicates Graeb IVH Scale - Right lateral ventricle score Right lateral ventricle score 1;2;3;4 Trace amount of blood or mild bleeding;< Half of the ventricle filled with blood;> Half of the ventricle filled with blood;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14267 Sophia timing sub type SophiaTimeSubTyp Sophia classification of stroke subtype by timing of stroke Sophia classification of stroke subtype by timing of stroke Identify the Sophia classification of stroke subtype by timing of stroke. Fetal stroke;Neonatal stroke;Presumed fetal or neonatal stroke Fetal stroke;Neonatal stroke;Presumed fetal or neonatal stroke Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14226 Stroke causative classification standard sub type StrokCausClassStandSubTyp Ischemic Stroke Subtype based on The Causative Classification System's - standard causative subtypes Ischemic Stroke Subtype based on The Causative Classification System's - standard causative subtypes Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard causative subtypes. Large artery atherosclerosis;Cardio-aortic embolism;Small artery occlusion;Other uncommon causes;Undetermined causes Either occlusive, or stenotic (greater than or equal to 50% diameter reduction or <50% diameter reduction with plaque ulceration or thrombosis or plaque with <50% diameter reduction that is seated at the site of the origin of the penetrating artery supplying the region of an acute lacunar infarct) vascular disease judged to be due to atherosclerosis in the clinically-relevant extracranial or intracranial arteries;Cardiac sources of embolism are segregated into high- and low-risk categories with reference to an objective 2% primary stroke risk threshold;Imaging evidence of a single and clinically relevant acute infarction less than 20 mm in greatest diameter within the territory of basal or brainstem penetrating arteries in the absence of any focal pathology in the parent artery at the site of the origin of the penetrating artery (focal atheroma, parent vessel dissection, vasculitis, vasospasm, etc.);Specific disease processes not included in the first 3 categories that involve clinically-appropriate brain arteries, including, a. Unknown-cryptogenic embolism: Angiographic evidence of abrupt cut-off in an otherwise normal looking artery or subsequent complete recanalization of a previously occluded artery, b. Unknown: Other cryptogenic strokes that do not fulfill the criteria for cryptogenic embolism, c. Unclassified: Multiple competing etiologies, d. Incomplete evaluation: Failure to investigate for a relevant etiology in the absence of positive evidence;Undetermined causes Alphanumeric

Choose one (the most likely mechanism).

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /><br />Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /><br />Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14244 Subarachnoid hemorrhage etiology type SAHEtiologyTyp Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowed Indicates the presumed cause(s) of the subarachnoid hemorrhage (SAH). Multiple responses are allowe Indicate the presumed cause(s) of the subarachnoid hemorrhage (SAH). Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Saccular aneurysm;Mycotic aneurysm;Cerebral AVM or other vascular malformation;Cerebral tumor;Illicit drug Use;Antithrombotic use;Spinal cord AVM;Spinal cord tumor;Other, specify;Undetermined;Fusiform aneurysm;Presumed amyloid angiopathy Alphanumeric

Select all that apply.

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14255 Subarachnoid hemorrhage volume total measurement SubarachHemVolTotalMeasr Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures Subarachnoid hemorrhage (SAH) volume scale (Hijdra) - total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissure Total amount of subarachnoid blood. Sum of the scores of the 10 basal cisterns and fissures. Numeric Values

The total amount of subarachnoid blood (sum score) is calculated by adding the 10 sub-scores. The range for the total is 0 - 30 (integers). This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 30 milliliter
C13832 Graeb intraventricular hemorrhage (IVH) scale - left lateral ventricle score GraebIVHScaleLeftLatVentScore Indicates Graeb IVH Scale - Left lateral ventricle score Indicates Graeb IVH Scale - Left lateral ventricle score Left lateral ventricle score 1;2;3;4 Trace amount of blood or mild bleeding;< Half of the ventricle filled with blood;> Half of the ventricle filled with blood;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14268 Sophia time detection type SophiaTimeDetTyp Time of detection of the stroke event in the participant/subject Time of detection of the stroke event in the participant/subject Identify the time of detection of the stroke event in the participant/subject. Fetal;Neonatal early/late (day after birth);Presumed fetal or perinatal Fetal;Neonatal early/late (day after birth);Presumed fetal or perinatal Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14228 Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) - standard sub type BWCYSSStandardSubTyp Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System Identify the Ischemic Stroke Subtype based on the Baltimore-Washington Cooperative Young Stroke Study (BWCYSS) Classification System. Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Atherosclerotic vasculopathy;Non-atherosclerotic vasculopathy;Vasculopathy of uncertain cause (lacunar);Cardiac/transcardiac embolism;Hematologic/ Other;Migrainous;Oral contraceptive and exogenous estrogen use;Other drug related;Indeterminate Alphanumeric

Choose all that apply, following the additional coding instructions. Two "Probable" diagnoses are allowed if criteria were met for two conditions of equal priority. [High priority diagnoses = Atherosclerotic vasculopathy, Non-atherosclerotic vasculopathy, Cardiac/transcardiac embolism, and Hematologic/other. Lower priority diagnoses = Vasculopathy of uncertain cause (lacunar), Migrainous, Oral contraceptive and exogenous estrogen use, Other drug related, and Indeterminate.] However, a lower priority diagnosis cannot be coded as probable when a higher priority probable or possible diagnosis is present; the lower priority diagnosis has to be assigned a possible label.

Johnson CJ, Kittner SJ, McCarter RJ, Sloan MA, Stern BJ, Buchholz D, Price TR. Interrater reliability of an etiologic classification of ischemic stroke. Stroke. 1995;26(1):46-51. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14245 Hunt and Hess scale HuntHessScale This is a 5 level scale for classifying the severity of Subarachnoid Hemorrhage (SAH), the higher the score the lower the likelihood of survival This is a 5 level scale for classifying the severity of Subarachnoid Hemorrhage (SAH), the higher the score the lower the likelihood of surviva Hunt Hess scale 1;2;3;4;5 Asymptomatic, mild headache, slight nuchal rigidity;Moderate to severe headache, nuchal rigidity, no neurologic deficit other than cranial nerve palsy;Drowsiness/confusion, mild focal neurologic deficit;Stupor, moderate-severe hemiparesis;Coma, decerebrate posturing Numeric values

Choose the best score

Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968;28(1):14-20. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14256 World Federation of Neurological Surgeons (WFNS) - grading system subarachnoid hemorrhage scale WFNSGraSySubHemScale World Federation of Neurological Surgeons (WFNS) Grading System for Subarachnoid Hemorrhage Scale World Federation of Neurological Surgeons (WFNS) Grading System for Subarachnoid Hemorrhage Scale World Federation of Neurological Surgeons (WFNS) Grading System for subarachnoid hemorrhage scale. 1;2;3;4;5 Glasgow Coma Scale of 15 AND a major focal deficit is absent;Glasgow Coma Scale of 13 - 14 AND a major focal deficit is absent;Glasgow Coma Scale of 13 - 14 AND a major focal deficit is present;Glasgow Coma Scale of 7 - 12 AND a major focal deficit is present/absent;Glasgow Coma Scale of 3 - 6 AND a major focal deficit is present/absent Numeric values

Glasgow Coma Scale = (Score for eye opening) + (score for best verbal response) + (score for best motor response)

Drake CG, Hunt WE, Sano K, et al. Report of World Federation of Neurological Surgeons Committee on a universal subarachnoid hemorrhage grading scale. J Neurosurg. 1988; 68(6):985-986. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13833 Graeb intraventricular hemorrhage (IVH) scale - third ventricle score GraebIVHScaleThirdVentScore Indicates Graeb IVH Scale - Third ventricle score Indicates Graeb IVH Scale - Third ventricle score Third ventricle score 1;2 Blood present without dilatation;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14269 Sophia signs symptoms presentation type SophiaSignSymPresTyp Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification Signs and symptoms exhibited by the neonate at presentation. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classificatio Identify the signs and symptoms exhibited by the neonate at presentation. Seizures;Other neurological signs, specify;Focal EEG changes;Chance findings during routine imaging, specify Seizures;Other neurological signs, specify;Focal EEG changes;Chance findings during routine imaging, specify Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14230 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - atherothrombotic grade ASCOSystemAtherothrGrade The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A) The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A Evaluate the patients for the predefined phenotype of atherosclerosis (A). 0;1;2;3;9 0=No disease is present.;1=Definitely a potential cause of the index stroke defined as: (a) Patients with any atherosclerotic stenosis 70–99% in an intra-/or extracranial artery supplying the ischemic field diagnosed by level A or B evidence| or (b) Any atherosclerotic stenosis <70% in an intra-/or extracranial artery supplying the ischemic field with attached luminal thrombus diagnosed by level A or B evidence| or (c) A mobile thrombus in the aortic arch| or (d) Occlusion with imaging evidence of atherosclerosis in an intra-/or extracranial artery supplying the ischemic field.;2=Causality uncertain: (a) Patients with any atherosclerotic stenosis 70–99% in an intra-/or extracranial artery supplying the ischemic field diagnosed by level C evidence| or (b) Any atherosclerotic stenosis <70% in an intra-/or extracranial artery supplying the ischemic field with attached luminal thrombus diagnosed by level C evidence| or (c) Aortic arch plaques >4 mm in thickness without a mobile component.;3=Unlikely a direct cause of index stroke (but disease is present): (a) Presence of carotid or vertebral artery plaque without stenosis| or (b) Aortic arch plaque <4 mm| or (c) Stenosis (any degree) in a brain artery, contralateral to the brain infarction or in the opposite circulation (either posterior or anterior circulation)| or (d) History of myocardial infarction or coronary revascularization or peripheral arterial disease.;9=Cannot be graded because no tests were performed. Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14246 Fisher scale FisherScale Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Fisher scale 1;2;3;4 No blood detected;Diffuse deposition of thin layer w/ all vertical layers of blood (interhemispheric fissure, insular cistern, ambient cistern) < 1 mm thick;Vertical Layers of blood 1 mm thick or localized clots (clots defined as > 3 x 5 mm);diffuse or no subarachnoid blood, but w/ intracerebral or intraventricular clots Numeric values

Choose the best score

Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 1980;6(1):1-9. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14257 Childhood stroke type ChildhoodStrokeTyp Indicates the type of clinical stroke suffered by the child Indicates the type of clinical stroke suffered by the chil Indicate the type of clinical stroke suffered by the child. Childhood arterial ischemic stroke;Childhood intracerebral hemorrhage;Childhood subarachnoid hemorrhage;Childhood intraventricular hemorrhage;Childhood TIA;Childhood Silent Stroke;Childhood cerebral venous thrombosis Childhood arterial ischemic stroke;Childhood intracerebral hemorrhage;Childhood subarachnoid hemorrhage;Childhood intraventricular hemorrhage;Childhood TIA;Childhood Silent Stroke;Childhood cerebral venous thrombosis Alphanumeric

Choose one per stroke event.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. Pediatric Supplemental-Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13834 Graeb intraventricular hemorrhage (IVH) scale - fourth ventricle score GraebIVHScaleFourVentScore Indicates Graeb IVH Scale - Fourth ventricle score Indicates Graeb IVH Scale - Fourth ventricle score Fourth ventricle score 1;2 Blood present without dilatation;Ventricle expanded and filled with blood Numeric values

No instructions available

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14270 Sophia stroke vessels affected type SophiaStrokVesselAffectTyp Vessel(s) affected by the stroke event. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification Vessel(s) affected by the stroke event. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classificatio Identify the vessel affected by the stroke event. Arterial cortical;Arterial perforator;Brainstem or spinal cord arteries;Sinus;Deep or Pial Vein;Lobar or Subarachnoid Arterial cortical;Arterial perforator;Brainstem or spinal cord arteries;Sinus;Deep or Pial Vein;Lobar or Subarachnoid Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14231 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - small vessel grade ASCOSystemSmallVesselGrade The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of small vessel disease (S) The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of small vessel disease (S Evaluate the patients for the predefined phenotype of small vessel disease (S). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke: Deep branch artery stroke: small, deep infarct with diameter <15 mm on MRI (or CT) in the territory corresponding to symptoms and either (b) One or several old or silent lacunar infarcts in territories different from the index stroke or (c) Leukoaraiosis on MRI (or CT), microbleeds on MRI (gradient echo imaging), dilatation of the perivascular spaces on MRI (or CT) or (d) Recent repeated similar TIAs – when they preceded the brain infarct by 1 month or less and attributable to the same territory as the subsequent BI (which increase the prediction for lacunar stroke from 57 to 80%, and are therefore supportive).;Causality uncertain: (a) Single, deep branch artery stroke or (b) Clinical syndrome suggestive of deep branch artery stroke with no MRI/CT evidence of stroke (clinical syndrome suggestive of a deep branch artery stroke – classic lacunar syndromes: pure motor hemiparesis, pure sensory syndrome, ataxic hemiparesis, dysarthria clumsy-hand syndrome, and sensorimotor syndrome or other 'nonlacunar' clinical syndromes. e.g. hemichorea, hemiballism, isolated dysarthria, etc.).;Unlikely a direct cause of index stroke (but disease is present): Leukoaraiosis on MRI (or CT), and/or microbleeds on MRI (gradient echo imaging), and/or dilatation of perivascular spaces on MRI (or CT), and/or one or several lacunar infarcts (silent or old) in territories different from the index stroke.;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14247 Modified fisher scale ModFisherScale Modified Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Modified Fisher scale characterizes the appearance of subarachnoid hemorrhage (SAH) on imaging Modified Fisher scale 0;1;2;3;4 No subarachnoid hemorrhage or intraventricular hemorrhage;subarachnoid hemorrhage less than 1 mm thick, no intraventricular hemorrhage;subarachnoid hemorrhage less than 1 mm thick, with intraventricular hemorrhage;subarachnoid hemorrhage more than 1 mm thick, no intraventricular hemorrhage;subarachnoid hemorrhage more than 1 mm thick, with intraventricular hemorrhage Numeric values

Choose the best score

Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, MacDonald RL, Mayer SA. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery. 2006 Jul;59(1):21-7; discussion 21-7. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14258 Perinatal stroke type PerinatalStrokeTyp Indicates the type of clinical stroke suffered by the neonate Indicates the type of clinical stroke suffered by the neonat Indicate the type of clinical stroke suffered by the neonate. Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Alphanumeric

Choose one per stroke event.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. Pediatric Supplemental-Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13835 Graeb intraventricular hemorrhage (IVH) scale - total score GraebIVHScaleTotaScore Indicates Graeb IVH Scale - total Score Indicates Graeb IVH Scale - total Score Total score Numeric Values

To calculate the total, sum the scores for the ventricles. Maximum score is 12.

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 12
C14271 Sophia imaging stroke composite diagnosis method type SophiaImgStrokCompDiaMethTyp Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classificatio Identify the imaging method at detection. Ultrasound;MRI/MRA/MRV;CT;Other, specify Ultrasound;MRI/magnetic resonance angiography/magnetic resonance venography;CT;Other, specify Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14232 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - cardioembolic grade ASCOSystemCardioembGrade The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C) The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C Evaluate the patients for the predefined phenotype of cardiac source (C). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke: (a) Mitral stenosis, (b) Prosthetic heart valve, (c) Myocardial infarction within the past 4 weeks, (d) Mural thrombus in left cavities, (e) Left ventricular aneurysm, (f) Any documented history or permanent or transient atrial fibrillation or flutter with or without spontaneous echo contrast or left atrial thrombus, (g) Sick sinus syndrome, (h) Dilated cardiomyopathy, (i) Ejection fraction <35%, (j) Endocarditis, (k) Intracardiac mass, (l) PFO plus in situ thrombosis, (m) PFO plus concomitant PE or DVT preceding the brain infarction.;Causality uncertain: (a) PFO and ASA, (b) PFO and concomitant DVT or PE (but not preceding the index stroke), (c) Spontaneous echo contrast, (d) Apical akinesia of the left ventricle and impaired ejection fraction (but >35%), (e) Only suggested by history of myocardial infarction or palpitation and multiple repeated brain infarcts on both sides or in both the anterior and posterior circulation, (f) Only suggested by abdominal CT/MRI or autopsy demonstration of the presence of systemic infarction (e.g. kidney, splenic, mesenteric) or lower limb embolism (in addition to the index stroke).;Unlikely a direct cause of index stroke: One of the following abnormalities: PFO, ASA, valvular strands, mitral annulus calcification, calcified aortic valve, nonapical akinesia of the left ventricle.;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14248 Ogilvy subarachnoid hemorrhage grade OgilvySubarachnoidHemGrade Ogilvy comprehensive grading system for classifying severity of SAH. In the system, 1 point is assigned for Hunt and Hess Grade 4 or 5, Fisher Scale score of 3 or 4, aneurysm size greater than 10 mm, patient age older than 50 years, and if the lesion is a giant (>= 25 mm) posterior circulation lesion. By adding the total points, the 5-point grading system is obtained Ogilvy comprehensive grading system for classifying severity of SAH. In the system, 1 point is assigned for Hunt and Hess Grade 4 or 5, Fisher Scale score of 3 or 4, aneurysm size greater than 10 mm, patient age older than 50 years, and if the lesion is Ogilvy subarachnoid hemorrhage (SAH) grading system 1;2;3;4;5 Dead;Poor;Fair;Good;Excellent Numeric values

Add the total points as described in the definition to calculate the Ogilvy grade.

Ogilvy CS, Carter BS. A proposed comprehensive grading system to predict outcome for surgical management of intracranial aneurysms. Neurosurgery 1998;42(5):959-968. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14259 Pediatric Stroke Classification (PSC) - sub type PSCSubTyp Pediatric Stroke Classification (PSC) system (Wraige, 2005) subtype Pediatric Stroke Classification (PSC) system (Wraige, 2005) subtype Indicate the Pediatric Stroke Classification (PSC) system subtype Sickle cell disease;Cardioembolic;Moyamoya Syndrome;Cervical arterial dissection;Steno-occlusive cerebral arteriopathy;Other determined etiology;Multiple probable/ possible etiologies;Undetermined etiology Sickle cell disease;Cardioembolic;Moyamoya Syndrome;Cervical arterial dissection;Steno-occlusive cerebral arteriopathy;Other determined etiology;Multiple probable/ possible etiologies;Undetermined etiology Alphanumeric

No instructions available

Wraige E, Pohl KR, Ganesan V. A proposed classification for subtypes of arterial ischemic stroke in children. Dev Med Child Neurol. 2005;47(4):252-256. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14219 Clinical stroke time-based definition indicator ClinStrokeTimeBasedDefinInd Indicates whether the patient suffered a clinical stroke according to the following, "time-based" definition: Stroke is a sudden focal neurological deficit of presumed vascular origin lasting >= 24 hours (or fatal within 24 hours) Indicates whether the patient suffered a clinical stroke according to the following, "time-based" definition: Stroke is a sudden focal neurological deficit of presumed vascular origin lasting >= 24 hours (or fatal within 24 hours Has the patient suffered a stroke according to the "time-based" definition? Yes;No;Unknown Yes;No;Unknown Alphanumeric

A clinical study should at a minimum use either the "time-based" or the "tissue-based" definition for clinical stroke. Some clinical studies may find it appropriate to use both definitions.

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089. Available at: http://stroke.ahajournals.org. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14626 Sophia delivery mode type SophiaDelModeTyp Mother's mode of delivery of the neonate. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification Mother's mode of delivery of the neonate. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classificatio Identify the mother's mode of delivery of the neonate. Spontaneous cephalic vaginal;Cephalic vaginal with instrumental traction (vacuum, forceps or both);Breech vaginal;Elective caesarean;Emergency caesarean Spontaneous cephalic vaginal;Cephalic vaginal with instrumental traction (vacuum, forceps or both);Breech vaginal;Elective caesarean;Emergency caesarean Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14233 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - other grade ASCOSystemOtherGrade The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of other cause (O) The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of other cause (O) Evaluate the patients for the predefined phenotype of other cause (O). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke (examples): (a) Arterial dissection by A or B evidence (table 3), (b) Dolichoectasia with complicated aneurysm, (c) Polycythemia vera, thrombocythemia >800,000/mm3, (d) Lupus erythematosus, (e) Disseminated intravascular coagulation, (f) Criteria for antiphospholipid antibody syndrome, (g) Fabry's disease, (h) Concomitant meningitis, (i) Sickle cell disease, (j) Ruptured cerebral aneurysm with or without demonstration of spasm in the territory of the brain infarct, (k) Homozygote for hyperhomocystinuria;Causality uncertain: (a) Arterial dissection diagnosed by level C evidence, (b) Fibromuscular dysplasia;Unlikely a direct cause of index stroke (but disease is present): (a) Kinking or dolichoectasia without complicated aneurysm or plicature, (b) Arteriovenous malformation or saccular aneurysm, (c) Thrombocytosis >450,000 and <800,000/mm3, (d) Antiphospholipid antibodies <100 GPL units, (e) Mild hyperhomocysteinemia heterozygote;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14249 Subarachnoid hemorrhage interhemispheric fissure score SubarachHemInterhemFisScore Subarachnoid hemorrhage column scale (Hijdra) for the interhemispheric fissure score SAH Volume Scale (Hijdra) - Interhemispheric fissure score Column scale (Hijdra) for the interhemispheric fissure score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14260 Sebire-International Pediatric Stroke Study (IPSS) - sub type SebireIPSSSubTyp The subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classification The subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classificatio Indicate the subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classification. Arteriopathy associated with sickle cell disease;Transient cerebral arteriopathy;Moyamoya Syndrome;Arterial dissection;Chronic inflammatory vasculitis;Neurofibromatosis type 1 (NF1);Fibromuscular dysplasia;Post irradiation arteriopathy;Metabolic arteriopathies;Cryptogenic arteriopathy Arteriopathy associated with sickle cell disease;Transient cerebral arteriopathy;Moyamoya Syndrome;Arterial dissection;Chronic inflammatory vasculitis;Neurofibromatosis type 1 (NF1);Fibromuscular dysplasia;Post irradiation arteriopathy;Metabolic arteriopathies;Cryptogenic arteriopathy Alphanumeric

No instructions available

Sebire G, Fullerton H, Riou E, deVeber G. Toward the definition of cerebral arteriopathies of childhood. Curr Opin Pediatr. 2004;16(6):617-622. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14220 Clinical stroke tissue-based definition indicator ClinStrokeTissBasedDefinInd Indicates whether the patient suffered a clinical stroke according to the following, "tissue-based" definition: Symptomatic stroke is a sudden focal neurological deficit, of any duration, due to focal brain, spinal cord, or retinal infarction or hemorrhage. Infarction or hemorrhage may be demonstrated either 1) directly by imaging/laboratory/pathologic examination in patients with symptom duration less than 24 hours, or 2) inferred by symptoms lasting >= 24 hours (or fatal within 24 hours) that cannot be attributed to another cause Indicates whether the patient suffered a clinical stroke according to a "tissue-based" definition Has the patient suffered a clinical stroke according to the "tissue-based" definition? Yes;No;Unknown Yes;No;Unknown Alphanumeric

A clinical study should at a minimum use either the "time-based" or the "tissue-based" definition for clinical stroke. Some clinical studies may find it appropriate to use both definitions.

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089. <br />Available at: http://stroke.ahajournals.org. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C18909 Intracerebral hemorrhage presumed cause other text ICHPresumedCauseOTH The free-text field related to 'Intracerebral hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowed The free-text field related to 'Intracerebral hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowe Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C14234 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - diagnostic evidence level type ASCOSystemDiagEvidLevTyp Levels of diagnostic evidence for the ASCO Grades Levels of diagnostic evidence for the ASCO Grades Identify the levels of diagnostic evidence for the ASCO grades. Level A;Level B;Level C Direct demonstration by gold standard diagnostic tests or criteria;Indirect evidence or less sensitive or specific tests or criteria;Weak evidence Alphanumeric

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14250 Subarachnoid hemorrhage Sylvian fissure lateral part score SubaracHemSylvianFisLatPaScore SAH Volume Scale (Hijdra) - Sylvian fissure lateral part left score SAH Volume Scale (Hijdra) - Sylvian fissure lateral part left score Sylvian fissure lateral part left score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

CSV