CDE Detailed Report

Disease: content
Sub-Domain: Laboratory Tests and Biospecimens/Biomarkers
CRF: welcome

Displaying 51 - 68 of 68
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C12518 Endomysial fibrosis severity status EndomysFibroSeverStat Severity of the Endomysial fibrosis muscle diagnostic abnormalities Severity of the Endomysial fibrosis muscle diagnostic abnormalities Endomysial fibrosis Mild;Moderate;Severe Mild;Moderate;Severe Alphanumeric

No instructions available

No references available Adult Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12243 Microscopy epon embedded tissue abnormality type MicscpyEponEmbedTissAbnrmlyTyp Type of microscopy employed to view abnormalities in epon-embedded tissue specimen Type of microscopy employed to view abnormalities in epon-embedded tissue specimen Abnormalities seen on Light microscopy (Toluidine blue staining);Electron microscopy;Both - light microscopy and electron microscopy Light microscopy (Toluidine blue staining);Electron microscopy;Both - light microscopy and electron microscopy Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12531 Biopsy autopsy excessive glycogen severity result BpApExessGlycoSeverReslt Severe glycogen storage pathology involves excess PAS+ material that is easily identifiable on light microscopy and is evident on other stains including H and E. Mild glycogen storage pathology is difficult to determine at the light microscopic level and may only be evident on PAS stain or electron microscopy. Severe glycogen storage pathology has excess PAS+ material easily seen on light microscopy, evident on stains H and E. Mild glycogen storage pathology difficult to determine at light microscopic level, may only appear on PAS stain or electron microscopy. Excessive glycogen Specify severity Mild;Severe Mild;Severe Alphanumeric

Only answered if "Excessive glycogen" is answered for "Abnormal storage material"

No references available Adult;Pediatric Supplemental 3.00 2013-07-25 08:54:08.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12257 Biopsy and autopsy nemaline rod type BpApNemaRodTyp Rod-shaped structures, visible at high magnification, which are most visible on Gomori trichrome stain and on EM preparations Rod-shaped structures, visible at high magnification, which are most visible on Gomori trichrome stain and on EM preparations Nemaline rods, Specify Restricted to one fiber type;Nuclear rods present Restricted to one fiber type;Nuclear rods present Alphanumeric

Only answered if "Nemaline rods" is answered for "Myopathy-associated pathological structures"

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12268 Immunohistochemical stain used muscle biopsy and autopsy type ImmhistchmclStnUseMuscBpAp Which immunohistochemical stains were used on muscle biopsy? Which immunohistochemical stains were used on muscle biopsy? Which immunohistochemical stains were used? Myosin immunohistochemistry;Dystrophin panel;Other stains for limb-girdle or congenital muscular dystrophy;Inflammatory myopathy panel Myosin immunohistochemistry;Dystrophin panel;Other stains for limb-girdle or congenital muscular dystrophy;Inflammatory myopathy panel Alphanumeric

Choose all that apply. If dystrophin panel, Other stains for limb-girdle or congenital muscular dystrophy, or Inflammatory myopathy panel were answered for "Which immunohistochemical stains were performed?", specify stains used.

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Multiple Pre-Defined Values Selected

C12231 Laboratory name LabName Name of laboratory where assessment was performed Name of laboratory where assessment was performed Name of laboratory where pathology was performed Alphanumeric

Record the laboratory name where pathology was performed

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations 255

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C12519 Myofiber degeneration severity status MyofibDegenSeverStat Severity of the Myofiber degeneration muscle diagnostic abnormalities Severity of the Myofiber degeneration muscle diagnostic abnormalities Myofiber degeneration Mild;Moderate;Severe Mild;Moderate;Severe Alphanumeric

No instructions available

No references available Adult Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12245 Symptom presentation type SymptmPresentTyp Symptoms participant/ subject shows at presentation Symptoms participant/ subject shows at presentation Symptoms at presentation Weakness;Hypotonia (floppiness);Muscle pain;Cardiac disease;Central nervous system disease;Unknown Weakness;Hypotonia (floppiness);Muscle pain;Cardiac disease;Central nervous system disease;Unknown Alphanumeric

Check all that apply.

No references available Adult;Pediatric Supplemental 3.10 2017-05-12 12:45:20.0 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Multiple Pre-Defined Values Selected

C17898 Laboratory director unknown indicator LabDirectorUnknownInd Indicator of unknown laboratory director Indicator of unknown laboratory director Name of laboratory director Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12258 Biopsy and autopsy central cores type BpApCentrlCoreTyp The composition of the central cores. The composition of the central cores. Central cores, Specify Structured;Unstructured Structured;Unstructured Alphanumeric

Only answered if "Central cores" is answered for "Myopathy-associated pathological structures"

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12269 Biopsy and autopsy immunohistochemical immunofluorescence assays performed BpApImnhschmImnflrsncAssyPerf List of stains used List of stains used Immunohistochemical/ Immunofluorescence assays performed Alphanumeric

List the stains used based upon answers in question 3

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations 255

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C12232 Laboratory director name LabDirectorName Name of laboratory director where assessment was performed Name of laboratory director where assessment was performed Name of laboratory director Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations 255

Free-Form Entry

C12520 Specimen type 1 fiber muscle biopsy percent result number SpecTyp1FibMuscBpPctResltNum Result for type 1 fiber muscle biopsy percent Result for type 1 fiber muscle biopsy percent Numeric Values

Only record Type 1 fiber percentage if Type 1 predominance is completed

No references available Adult Supplemental 3.00 2013-07-25 08:54:08.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

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C12247 Biopsy and Autopsy tissue collection method type BpApTissCollMethdTyp The type of method used for collection of the tissue specimen The type of method used for collection of the tissue specimen Biopsy method Punch biopsy;Blister biopsy;Open biopsy;Open;Needle Punch biopsy;Blister biopsy;Open biopsy;Open;Needle Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C17899 Preservation technique not used indicator PreservTechNotUseInd Indicates preservation technique used is not known Indicates preservation technique used is not known Freezing or Fixation Used? Yes;No:Unknown Yes;No:Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12259 Biopsy and autopsy inflammation type BpApInflamTyp Perivascular inflammation is focused around blood vessels, whereas diffuse inflammation also spreads across the muscle tissue. Inflammatory cells identified include lymphocytes, neutrophils, macrophages, and eosinophils. At times, microorganisms can be identified and should be mentioned. Perivascular inflammation focused around blood vessels, diffuse inflammation spread across muscle tissue. Inflammatory cells identified: lymphocytes, neutrophils, macrophages, eosinophils. At times, microorganisms can be identified, should be mentioned. Specify Perivascular;Diffuse;Associated with myofiber damage;Inflammatory cells identified;Microorganisms identified Perivascular;Diffuse;Associated with myofiber damage;Inflammatory cells identified;Microorganisms identified Alphanumeric

Only answered if "Inflammation" is answered for "Which of the following diagnostic abnormalities were noted on histochemical stains?"

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

C12270 Biopsy and autopsy antibodies used name BpApAntibodUseName List the names of antibodies used List the names of antibodies used Name of antibodies used Alphanumeric

If names of antibodies used is not known, select Not known.

No references available Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations 255

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C12233 Preservation technique used type PresrvtnTechnqUseTyp Type of preservation technique used to preserve the specimen Type of preservation technique used to preserve the specimen Freezing or Fixation Used? Frozen;Formalin-fixed;Paraffin-embedded;Epon-embedded Frozen;Formalin-fixed;Paraffin-embedded;Epon-embedded Alphanumeric

No instructions available

No references available Adult;Pediatric Core 3.00 2013-07-24 11:38:01.2 Muscle Biopsy and Autopsy Tissue Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

Single Pre-Defined Value Selected

CSV