CDE Detailed Report
Disease: Parkinson's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology
Displaying 1 - 50 of 83
Sub-Domain: Other Clinical Data
CRF: Neuropathology
Displaying 1 - 50 of 83
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guideline) | Sub Domain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C08202 | Motor neuron disease indicator | MotrNrnDisInd | Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons | Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons | Motor Neuron Disease | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08167 | Brain abnormality microscopic type | BrainAbnrmlyMicroscpcTyp | Type of microscopic brain abnormality identified through staining | Type of microscopic brain abnormality identified through staining | Staining methods used for tangles, plaques, Lewy Bodies, and TDP-43 | Tangles;Plaques;Lewy bodies;TDP-43 | Tangles;Plaques;Lewy bodies;TDP-43 | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08215 | Pathologic diagnosis or feature status | PthlgcDiagnsisFeatureStatus | Extent to which the pathologic diagnosis or feature affected the participant/subject | Extent to which the pathologic diagnosis or feature affected the participant/subject | Primary cause;Contributing cause | Primary cause;Contributing cause | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C02411 | Laterality type | LatTyp | Laterality type relative to the anatomic site of the body examined or affected | Laterality type relative to the anatomic site of the body examined or affected | What hemisphere of brain was evaluated? | Bilateral;Left;Right;N/A | Bilateral;Left;Right;Not present | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-08-28 16:08:00.453 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08178 | Subcortical arteriosclerotic leukoencephalopathy indicator | SubcortclArtrsclrtcLkecphInd | Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts | Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts | Is subcortical aeteriosclerotic leukoencephalopathy present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
White matter rarefaction confined to the immediate periventricular region (so-called periventricular capping) should not be included. Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18742 | Pathologic diagnosis extrapyramidal movement other text | PthlgcDgnsisExtrpyrmdlMvmntOTH | The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C08156 | Specimen other postmortem indicator | SpecmnOtherPstmortemInd | Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Other banked postmortem specimen | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08190 | Lewy body type | LewyBdyTyp | Type of Lewy body assessed | Type of Lewy body assessed | Lewy body type | Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown | Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown | Alphanumeric |
Choose all that apply |
MCKEITH, I. G., DICKSON, D. W., LOWE, J., EMRE, M., O'BRIEN, J. T., FELDMAN, H., CUMMINGS, J., DUDA, J. E., LIPPA, C., PERRY, E. K., AARSLAND, D., ARAI, H., BALLARD, C. G., BOEVE, B., BURN, D. J., COSTA, D., DEL SER, T., DUBOIS, B., GALASKO, D., GAUTHIER, S., GOETZ, C. G., GOMEZ-TORTOSA, E., HALLIDAY, G., HANSEN, L. A., HARDY, J., IWATSUBO, T., KALARIA, R. N., KAUFER, D., KENNY, R. A., KORCZYN, A., KOSAKA, K., LEE, V. M., LEES, A., LITVAN, I., LONDOS, E., LOPEZ, O. L., MINOSHIMA, S., MIZUNO, Y., MOLINA, J. A., MUKAETOVA-LADINSKA, E. B., PASQUIER, F., PERRY, R. H., SCHULZ, J. B., TROJANOWSKI, J. Q. & YAMADA, M. 2005. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 1863-72. ALAFUZOFF, I., INCE, P. G., ARZBERGER, T., AL-SARRAJ, S., BELL, J., BODI, I., BOGDANOVIC, N., BUGIANI, O., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., IRONSIDE, J. W., KAVANTZAS, N., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., MEYRONET, D., MONORANU, C., PARCHI, P., PARKKINEN, L., PATSOURIS, E., ROGGENDORF, W., ROZEMULLER, A., STADELMANN-NESSLER, C., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2009a. Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol, 117, 635-52. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C08203 | Fuse in sarcoma abnormal pathology indicator | FusInSarcmaAbnrmlPathlgyInd | Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present | Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present | Is abnormal FUS pathology present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
MACKENZIE, I. R., NEUMANN, M., BIGIO, E. H., CAIRNS, N. J., ALAFUZOFF, I., KRIL, J., KOVACS, G. G., GHETTI, B., HALLIDAY, G., HOLM, I. E., INCE, P. G., KAMPHORST, W., REVESZ, T., ROZEMULLER, A. J., KUMAR-SINGH, S., AKIYAMA, H., BABORIE, A., SPINA, S., DICKSON, D. W., TROJANOWSKI, J. Q. & MANN, D. M. 2010. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol, 119, 1-4. MUNOZ, D. G., NEUMANN, M., KUSAKA, H., YOKOTA, O., ISHIHARA, K., TERADA, S., KURODA, S. & MACKENZIE, I. R. 2009. FUS pathology in basophilic inclusion body disease. Acta Neuropathol, 118, 617-27. NEUMANN, M., RADEMAKERS, R., ROEBER, S., BAKER, M., KRETZSCHMAR, H. A. & MACKENZIE, I. R. 2009a. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain, 132, 2922-31. NEUMANN, M., ROEBER, S., KRETZSCHMAR, H. A., RADEMAKERS, R., BAKER, M. & MACKENZIE, I. R. 2009b. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathol, 118, 605-16. | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08168 | Immunohistochemistry stain method name | ImmunhistchmstryStainMethdName | Name of staining method used for immunohistochemistry | Name of staining method used for immunohistochemistry | Immunohistorchemistry (IHC) | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C17398 | Specimen other postmortem text | SpecOthPostmortText | Text area to describe other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Description of other available banked postmortem specimens | Yes, specify | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2012-12-20 00:00:00.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C04802 | Death date and time | DeathDateTime | Date (and time, if known) of participant's/subject's death | Date (and time, if known) of participant's/subject's death | Date of death | Date or Date & Time |
(DD/MMM/YYYY) |
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
2004152 | |||||||||
| C08179 | Cortical laminar necrosis indicator | CortclLamnrNecrsisInd | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Is cortical laminar necrosis present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18743 | Pathologic diagnosis responsible cognitive status other text | PthgcDgnsisRspCgntvStatOTH | The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C08157 | Photograph macroscopic indicator | PhotographsMacroscopicInd | Indicator of whether macroscopic photographs were taken | Indicator of whether macroscopic photographs were taken | Macroscopic photographs | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08191 | Substantia nigral neuromelanin-containing neurons neuronal loss scale | SbstntNgrlNromlnCntnNrnLssScl | Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra | Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra | Estimate degree of substantia nigral neruomelanin-containing neuronal loss | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric |
Choose one |
DICKSON, D. W., BRAAK, H., DUDA, J. E., DUYCKAERTS, C., GASSER, T., HALLIDAY, G. M., HARDY, J., LEVERENZ, J. B., DEL TREDICI, K., WSZOLEK, Z. K. & LITVAN, I. 2009. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol, 8, 1150-7. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08204 | Frontotemporal Lobar Degeneration (FTLD) - other type indicator | FTLDOthrTypInd | Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present | Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present | Is another type of FTLD present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no, skip to Question 40 |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08169 | Antibody stain method name | AntibdyStainMethdName | Name of staining method used for antibodies | Name of staining method used for antibodies | Antibodies | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C17400 | Other pathology ischemic vascular disease text | OthrPathlgyIschmcVasclrDisTxt | Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously | Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously | Yes, specify | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 1.00 | 2012-12-20 00:00:00.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C06005 | Data collected date and time | DataCollDateTime | Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. | Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. | Date form completed | Date or Date & Time |
(DD/MMM/YYYY) |
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 21:00:23.88 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
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| C08180 | Medial temporal lobe sclerosis indicator | MedialTemprlLbeSclersisInd | Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures | Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures | Is medial temporal lobe sclerosis that is considered to be ischemic in nature present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
In the hippocampus, this is often limited to CA1 and the subiculum with variable involvement of endplate and CA2. The amygdala and entorhinal cortex may also be affected. In some cases there is a clear history of cerebral hypoperfusion. In others there may be a history of epilepsy. Similar pathology can also be seen in the setting of neurodegenerative disorders (e.g., FTD). Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18744 | Pathologic disorder other specify text | PatholgcDisordrOthrST | The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present | The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present | Other, specify | Alphanumeric |
Choose one. If YES is answered then specify the other major pathologic disorder. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C08158 | Brain weight measurement | BrainWgtMeasr | Weight of the participant's/subject's brain in grams | Weight of the participant's/subject's brain in grams | Record brain weight (grams) | Numeric Values | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-20 10:46:24.96 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
gram | ||||||||||
| C08192 | Alpha-synuclein pathology type | AlphaSynuclnPathlgyTyp | Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown | Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown | Alphanumeric |
No instructions available |
LANTOS, P. L. 1998. The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol, 57, 1099-111. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08205 | Frontotemporal Lobar Degeneration (FTLD) - type | FTLDTyp | Types of Frontotemporal Lobar Degeneration (FTLD) assessed | Types of Frontotemporal Lobar Degeneration (FTLD) assessed | FTLD-OTHER | FTLD-UPS (ubiquitin-positive inclusions, but tau, TDP-43 and FUS negative);FTLD-NI (No inclusion);FTLD-NOS (Not otherwise specific or incompletely characterized) | FTLD-UPS (ubiquitin-positive inclusions, but tau, TDP-43 and FUS negative);FTLD-NI (No inclusion);FTLD-NOS (Not otherwise specific or incompletely characterized) | Alphanumeric |
Answered only if Question 39 (Is another type of FTLD present?) is answered YES. For each type of FTLD indicate whether it is present. |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08170 | Neuritic plaque density category | NeuriticPlaqDenstyCat | Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). | Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). | Neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores) | No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown | No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown | Alphanumeric | MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C17407 | Tauopathy not specified or incompletely characterized text | TauNotSpeIncomChTxt | Text field for a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain not specified or completely described. | Text field for a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain not specified or completely described. | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C08147 | Data source | DataSource | Source of the data provided on the case report form | Source of the data provided on the case report form | Data Source | Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse | Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-20 10:46:24.96 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C08181 | Other pathology ischemic vascular disease indicator | OthrPathlgyIschmcVasclrDisInd | Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously | Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously | Is there other pathology related to ischemic or vascular disease not previously specified present? | Yes, specify;No;Not assessed;Unknown | Yes, specify;No;Not assessed;Unknown | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18746 | Prion disease other specify text | PrionDisOthrST | The free-text field related to 'Prion disease other indicator'. Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present | The free-text field related to 'Prion disease other indicator'. Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present | Yes, specify | Alphanumeric |
Answered only if Question 40 (Is there pathology consistent with transmissible spongiform encephalopathy?) is answered YES. Choose one. If YES is answered then specify the other prion disease. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C08160 | Brain tissue weigh type | BrainTissWeighedTyp | Type of brain tissue weighed | Type of brain tissue weighed | Type of tissue weighed | Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half | Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08193 | Spinocerebellar degeneration indicator | SpinocrblrDegnrtnInd | Indicator of whether the participant/subject has spinocerebellar degenerations | Indicator of whether the participant/subject has spinocerebellar degenerations | Spinocerebellar degenerations | Yes, specify;No;Not assessed;Unknown | Yes, specify;No;Not assessed;Unknown | Alphanumeric |
No instructions available |
GWINN-HARDY, K., CHEN, J. Y., LIU, H. C., LIU, T. Y., BOSS, M., SELTZER, W., ADAM, A., SINGLETON, A., KOROSHETZ, W., WATERS, C., HARDY, J. & FARRER, M. 2000. Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese. Neurology, 55, 800-5. GWINN-HARDY, K., SINGLETON, A., O'SUILLEABHAIN, P., BOSS, M., NICHOLL, D., ADAM, A., HUSSEY, J., CRITCHLEY, P., HARDY, J. & FARRER, M. 2001. Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family. Arch Neurol, 58, 296-9. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08206 | Frontotemporal Lobar Degeneration (FTLD) - type indicator | FTLDTypInd | Whether the specific type of FTLD is present | Whether the specific type of FTLD is present | Is another type of FTLD present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Answered only if Question 39 (Is another type of FTLD present?) is answered YES. |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08171 | Diffuse plaques density category | DiffusePlaqDenstyCat | Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) | Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) | Diffuse Plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) | No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown | No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown | Alphanumeric |
Choose one |
MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C17423 | Spinocerebellar degeneration type text | SpinDegTypTxt | Text area to describe the type of spinocerebellar degenerations | Text area to describe the type of spinocerebellar degenerations | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C08148 | Neuropath specimen identifier number | NeuropthSpecmnIDNum | Unique identification number given to the neuropathology specimen | Unique identification number given to the neuropathology specimen | Neuropath ID | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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| C08183 | Atherosclerotic vascular pathology severity scale | AthrsclrtcVasclrPthlgySvrtyScl | Whether or not atherosclerotic vascular pathology (of the circle of Willis) is present and if so, its severity | Whether or not atherosclerotic vascular pathology (of the circle of Willis) is present and if so, its severity | Is atherosclerotic vascular pathology (of the circle of Willis) present? | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric |
Choose one |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08195 | Frontotemporal degeneration tau pathology indicator | FrntmprlDgnrtnTauPathlgyInd | Indicator of whether frontotemporal degeneration with tau pathology is present | Indicator of whether frontotemporal degeneration with tau pathology is present | Is frontotemporal degeneration with tau pathology present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no, skip to Question 35 |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18754 | Spinocerebellar degeneration specify text | SpinocrblrDegnrtnST | The free-text field related to 'Spinocerebellar degeneration indicator specify text'. Indicator of whether the participant/subject has spinocerebellar degenerations | The free-text field related to 'Spinocerebellar degeneration indicator specify text'. Indicator of whether the participant/subject has spinocerebellar degenerations | Yes, specify | Alphanumeric |
No instructions available |
GWINN-HARDY, K., CHEN, J. Y., LIU, H. C., LIU, T. Y., BOSS, M., SELTZER, W., ADAM, A., SINGLETON, A., KOROSHETZ, W., WATERS, C., HARDY, J. & FARRER, M. 2000. Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese. Neurology, 55, 800-5. GWINN-HARDY, K., SINGLETON, A., O'SUILLEABHAIN, P., BOSS, M., NICHOLL, D., ADAM, A., HUSSEY, J., CRITCHLEY, P., HARDY, J. & FARRER, M. 2001. Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family. Arch Neurol, 58, 296-9. | Adult | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
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| C08161 | Hydrocephalus severity scale | HydrcephlsSevrtyScale | Scale of the severity of the hydrocephalus | Scale of the severity of the hydrocephalus | Hydrocephalus | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08207 | Transmissible spongiform encephalopathy indicator | TransmssblSpngfrmEncphlpthyInd | Whether or not pathology is consistent with transmissible spongiform encephalopathy | Whether or not pathology is consistent with transmissible spongiform encephalopathy | Is there a pathology consistent with transmissible spongiform encephalopathy | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no, skip to Question 41 |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08172 | Beta-amyloidal plaque accumulation stage | BetaAmyldlPlaqAccmltnStage | Extent of beta-amyloidal plaque accumulation through the brain | Extent of beta-amyloidal plaque accumulation through the brain | Amyloid phase | Phase I (cortex);Phase 2 (cortex and hippocampus);Phase 3 (cortex, hippocampus, and basal ganglia);Phase 4 (cortex, hippocampus, basal ganglia, and brainstem);Phase 5 (cortex, hippocampus, basal ganglia, brainstem, and cerebellum);Amyloid plaques not present;Incompletely assessed;Not assessed;Unknown | Phase I (cortex);Phase 2 (cortex and hippocampus);Phase 3 (cortex, hippocampus, and basal ganglia);Phase 4 (cortex, hippocampus, basal ganglia, and brainstem);Phase 5 (cortex, hippocampus, basal ganglia, brainstem, and cerebellum);Amyloid plaques not present;Incompletely assessed;Not assessed;Unknown | Alphanumeric |
Choose one |
ALAFUZOFF, I., THAL, D. R., ARZBERGER, T., BOGDANOVIC, N., AL-SARRAJ, S., BODI, I., BOLUDA, S., BUGIANI, O., DUYCKAERTS, C., GELPI, E., GENTLEMAN, S., GIACCONE, G., GRAEBER, M., HORTOBAGYI, T., HOFTBERGER, R., INCE, P., IRONSIDE, J. W., KAVANTZAS, N., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., MEYRONET, D., MONORANU, C., NILSSON, T., PARCHI, P., PATSOURIS, E., PIKKARAINEN, M., REVESZ, T., ROZEMULLER, A., SEILHEAN, D., SCHULZ-SCHAEFFER, W., STREICHENBERGER, N., WHARTON, S. B. & KRETZSCHMAR, H. 2009b. Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol, 117, 309-20. THAL, D. R., RUB, U., ORANTES, M. & BRAAK, H. 2002. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology, 58, 1791-800. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18030 | Neuritic plaque brain region score anatomic site | NeurtcPlaqBrnRegnScoreAnatcSit | The anatomic site as it relates to the region in the brain where the neuritic plaques were scored | The anatomic site as it relates to the region in the brain where the neuritic plaques were scored | Region of brain neuritic plaques scored | Left;Right;Both;N/A | Left;Right;Both;N/A | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-20 10:46:24.96 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08149 | Diagnosis final clinical death type | DiagnosFinalClinDeathTyp | Physician's final clinical diagnosis for the participant/subject | Physician's final clinical diagnosis for the participant/subject | Final Clinical Diagnosis Before Death | Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease | Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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| C08184 | Arteriosclerosis severity scale | ArtrScalersisSevScl | Whether or not arteriosclerosis (small parenchymal arteriolar disease) is present and if so, its severity | Whether or not arteriosclerosis (small parenchymal arteriolar disease) is present and if so, its severity | Is arteriosclerosis (small parenchymal arteriolar disease) present? | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric |
Choose one |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08196 | Tauopathy disease type | TaupthyDisTyp | Presence of disease resulting from the pathological aggregation of tau protein | Presence of disease resulting from the pathological aggregation of tau protein | Tauopathies | Pick's Disease;Corticobasal degeneration;Progressive supranuclear palsy;Argyrophilic grain dementia (including diffuse AGD);Other 4R tauopathy (e.g., multisystem tauopathy);Tangle-predominant dementia (including Parkinson dementia complex) | Pick's Disease;Corticobasal degeneration;Progressive supranuclear palsy;Argyrophilic grain dementia (including diffuse AGD);Other 4R tauopathy (e.g., multisystem tauopathy);Tangle-predominant dementia (including Parkinson dementia complex) | Alphanumeric |
No instructions available |
DICKSON, D. W. 1998. Pick's disease: a modern approach. Brain Pathol, 8, 339-54. DICKSON, D. W., BERGERON, C., CHIN, S. S., DUYCKAERTS, C., HOROUPIAN, D., IKEDA, K., JELLINGER, K., LANTOS, P. L., LIPPA, C. F., MIRRA, S. S., TABATON, M., VONSATTEL, J. P., WAKABAYASHI, K. & LITVAN, I. 2002. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol, 61, 935-46. LANTOS, P. L. 1994. The neuropathology of progressive supranuclear palsy. J Neural Transm Suppl, 42, 137-52. TOLNAY, M. & CLAVAGUERA, F. 2004. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology, 24, 269-83. BIGIO, E. H., LIPTON, A. M., YEN, S. H., HUTTON, M. L., BAKER, M., NACHARAJU, P., WHITE, C. L., 3RD, DAVIES, P., LIN, W. & DICKSON, D. W. 2001. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. J Neuropathol Exp Neurol, 60, 328-41. KOVACS, G. G., MAJTENYI, K., SPINA, S., MURRELL, J. R., GELPI, E., HOFTBERGER, R., FRASER, G., CROWTHER, R. A., GOEDERT, M., BUDKA, H. & GHETTI, B. 2008. White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol, 67, 963-75. JELLINGER, K. A. & BANCHER, C. 1998. Senile dementia with tangles (tangle predominant form of senile dementia). Brain Pathol, 8, 367-76. HOF, P. R., PERL, D. P., LOERZEL, A. J. & MORRISON, J. H. 1991. Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease. Brain Res, 564, 306-13. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C18766 | Tauopathy not specified incompletely characterized specify text | TpthyNtSpcfdIncmpltChrctrzdST | The free-text field related to 'Tauopathy not specified incompletely characterized indicator'. Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized | The free-text field related to 'Tauopathy not specified incompletely characterized indicator'. Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized | Yes, specify | Alphanumeric |
Choose one |
No references available | Adult | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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| C08162 | National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale | NIAReaganInNeuropathCritScale | National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. | National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. | NIA/Reagan Institute neuropathological criteria | Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Unknown | Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Unknown | Alphanumeric | HYMAN, B. T. & TROJANOWSKI, J. Q. 1997. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08209 | Creutzfeldt-Jakob disease variant indicator | CrtzfldtJkbDisVarntInd | Whether or not Creutzfeldt-Jakob disease (CJD) or variant CJD is present | Whether or not Creutzfeldt-Jakob disease (CJD) or variant CJD is present | Is Creutzfeldt-Jakob disease or variant CJD present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Answered only if Question 40 (Is there pathology consistent with transmissible spongiform encephalopathy?) is answered YES. |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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| C08173 | Ischemic hemorrhagic or vascular pathology indicator | IschHemVasclPathInd | Indicator of the presence of ischemic, hemorrhagic, or vascular pathology | Indicator of the presence of ischemic, hemorrhagic, or vascular pathology | Is ischemic, hemorrhagic or vascular pathology present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no,skip to Question 24 |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
