CDE Detailed Report
Sub-Domain: Other Clinical Data
CRF: Neuropathology
Displaying 1 - 50 of 83
CDE ID | CDE Name | Variable Name | Definition | Short Description | Question Text | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guideline) | Sub Domain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | External Id Loinc | External Id Snomed | External Id caDSR | External Id CDISC |
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C08186 | Other angiopathy type indicator | OthrAngpthyTypInd | Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present | Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present | Is another type of angiopathy (e.g., CADASIL or arteritis) present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18032 | Other major pathologic disorder name | OthrMjrPathlgcDisordrNam | Names of the other major pathologic disorders present. | Names of the other major pathologic disorders present. | List other disorders | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-20 10:46:24.96 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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C08152 | Brain tissue frozen indicator | BrainTissFrozenInd | Indicator of whether banked frozen brain tissue is accessible | Indicator of whether banked frozen brain tissue is accessible | Is banked frozen brain tissue accessible? | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08164 | ADRDA Khachaturian neuropathological criteria result | ADRDAKhachtrnNeuropthCritrRes | ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease | ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease | ADRDA/Khachaturian neuropathological critera | Alzheimer's disease;Criteria not met;Not assessed;Unknown | Alzheimer's disease;Criteria not met;Not assessed;Unknown | Alphanumeric | KHACHATURIAN, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch Neurol, 42, 1097-105. | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08198 | Tauopathy not specified incompletely characterized indicator | TpthyNtSpcfdIncmpltChrctrzdInd | Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized | Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized | Other Tauopathies | Yes, specify;No;Not assessed;Unknown | Yes, specify;No;Not assessed;Unknown | Alphanumeric |
Choose one |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08175 | Cortical microinfarct indicator | CortclMicroinfarcInd | Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity | Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity | Are one or more cortical microinfarcts (including "granular atrophy") present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Infarcts meeting these criteria are included regardless of the histologic age and include acute lesions as well as chronic cystic lesions. 'Microinfarcts in non-cortical areas should not be included in this category. 'Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08211 | Pathologic disorder other indicator | PatholgcDisordrOthrInd | Whether or not there are other major pathologic disorders that are present | Whether or not there are other major pathologic disorders that are present | Are other major pathologic disorders present (not addressed)? | Yes, specify;No;Not assessed;Unknown | Yes, specify;No;Not assessed;Unknown | Alphanumeric |
Choose one. If YES is answered then specify the other major pathologic disorder. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08187 | Lewy body pathology indicator | LewyBdyPathlgyInd | Whether or not Lewy body pathology is present | Whether or not Lewy body pathology is present | Is Lewy body pathology present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no,skip to Question 31 |
BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18667 | Data source other text | DataSourcOTH | The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form | The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form | Other, specify | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08153 | Brain tissue formalin-fixed indicator | BrainTissFormalinFixedInd | Indicator of whether formalin-fixed brain tissue is accessible | Indicator of whether formalin-fixed brain tissue is accessible | Is formalin-fixed brain tissue accessible? | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08165 | Other unspecific neuropathological criteria result | OthrUnspcfcNeuropthCritrReslt | Other or unspecified neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease | Other or unspecified neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease | Other or unspecified criteria | Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown | Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown | Alphanumeric | No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08200 | Abnormal TPD-43 pathology indicator | AbnrmlTPD43PathlgyInd | Whether or not abnormal TPD-43 pathology is present | Whether or not abnormal TPD-43 pathology is present | Is abnormal TDP-43 pathology present | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
CAIRNS, N. J., BIGIO, E. H., MACKENZIE, I. R., NEUMANN, M., LEE, V. M., HATANPAA, K. J., WHITE, C. L., 3RD, SCHNEIDER, J. A., GRINBERG, L. T., HALLIDAY, G., DUYCKAERTS, C., LOWE, J. S., HOLM, I. E., TOLNAY, M., OKAMOTO, K., YOKOO, H., MURAYAMA, S., WOULFE, J., MUNOZ, D. G., DICKSON, D. W., INCE, P. G., TROJANOWSKI, J. Q. & MANN, D. M. 2007. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (Berl), 114, 5-22. | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08176 | Lacunes single or multiple indicator | LacunesSingMultiInd | Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matter | Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels. | Are one or more lacunes (small artery infarcts and/or hemorrhages) present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08213 | Pathologic diagnosis responsible cognitive status type | PthgcDgnsisRspCgntvStatTyp | Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | What are the primary and contributing pathologic diagnoses or features which you judge to be responsible for the subject's cognitive status? | No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Vascular disease;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Other, specify | No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Vascular disease;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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C08188 | Lewy related pathology anatomic site | LewyReltPathlgyAntmicSite | Brain region where Lewy body pathology was assessed | Brain region where Lewy body pathology was assessed | Density of "Lewy related pathology present" by regions | Sympathetic ganglia (paravertebral);Parasympathetic ganglia (GI, GU);Spinal Cord;Olfactory bulb;Dorsal motor nucleus/glossopharyngeal;Locus ceruleus;Raphe;Substantia nigra;pars compacta;Amygdala;Basal nucleus/diagonal band;Hypothalamus;Caudate/putamen;Entorhinal cortex;Cingulate cortex;Hippocampus;Temporal cortex;Frontal cortex;Parietal cortex;Primary cortex (motor and/or visual) | Sympathetic ganglia (paravertebral);Parasympathetic ganglia (GI, GU);Spinal Cord;Olfactory bulb;Dorsal motor nucleus/glossopharyngeal;Locus ceruleus;Raphe;Substantia nigra;pars compacta;Amygdala;Basal nucleus/diagonal band;Hypothalamus;Caudate/putamen;Entorhinal cortex;Cingulate cortex;Hippocampus;Temporal cortex;Frontal cortex;Parietal cortex;Primary cortex (motor and/or visual) | Alphanumeric |
No instructions available |
BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18669 | Diagnosis final clinical death other text | DiagnosFinalClinDeathOTH | The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject | The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject | Other, specify | Alphanumeric | No references available | Adult | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08154 | Brain tissue paraffin-embedded indicator | BrainTissParaffinEmbeddedInd | Indicator of whether paraffin-embedded blocks of brain tissue are accessible | Indicator of whether paraffin-embedded blocks of brain tissue are accessible | Are paraffin-embedded blocks of brain tissue accessible? | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08166 | Brain atrophy Braak and Braak neurofibrillary stage | BrAtBraakBraakNeurofibStage | Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. | Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. | Braak and Braak Neurofibrillary Stage | Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown | Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown | Alphanumeric |
Answer 'Not Assessed' if topographic staging has not been done. |
BRAAK, H. & BRAAK, E. 1991. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl), 82, 239-59. BRAAK, H. & BRAAK, E. 1997. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging, 18, 351-7. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08201 | Hippocampal sclerosis indicator | HippcmplSclrsisInd | Whether or not the participant/subject has hippocampal sclerosis of the elderly associated with TDP-43 pathology | Whether or not the participant/subject has hippocampal sclerosis of the elderly associated with TDP-43 pathology | Hippocampal sclerosis of the elderly associated with TDP-43 pathology | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
AMADOR-ORTIZ, C., LIN, W. L., AHMED, Z., PERSONETT, D., DAVIES, P., DUARA, R., GRAFF-RADFORD, N. R., HUTTON, M. L. & DICKSON, D. W. 2007. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol, 61, 435-45. | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08177 | Hemorrhage indicator | HemrrhgInd | Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain | Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain | Are single or multiple hemorrhages present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08214 | Pathologic diagnosis extrapyramidal movement type | PthlgcDgnsisExtrpyrmdlMvmntTyp | Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | What are the primary and contributing pathologic diagnoses or features which you judge to be responsible for the subject's extrapyramidal movement disorders, if present? | No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Vascular Parkinsonism;Idiopathic nigral degeneration;Hippocampal sclerosis;Other, specify | No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Vascular Parkinsonism;Idiopathic nigral degeneration;Hippocampal sclerosis;Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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C00035 | Gender type | GenderTyp | Self-reported gender of the participant/subject. | Self-reported gender of the participant/subject.. | Gender | Alphanumeric |
Choose one. Response is obtained by report of the participant/subject or caretaker. |
The NIH Guidelines on Inclusion of Women and Minorities as Subjects in Clinical Research: The Office of Management and Budget (OMB) Directive No. 15 - http://grants.nih.gov/grants/funding/women_min/women_min.htm | Adult;Pediatric | Core | 3.00 | 2013-08-28 16:08:00.453 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
2200604 | |||||||||
C08155 | CSF postmortem indicator | CSFPstmortemInd | Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible | Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible | Is banked postmortem cerebrospinal fluid accessible? | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08189 | Lewy related pathology severity scale | LewyReltPathlgySevrtyScale | Severity of the density of "Lewy related pathology" by region | Severity of the density of "Lewy related pathology" by region | None, Mild, Moderate, Severe, Not assessed, Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric |
No instructions available |
BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18741 | Other pathology ischemic vascular disease specify text | OthrPathlgyIschmcVasclrDisST | The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously | The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously | Other, specify | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08167 | Brain abnormality microscopic type | BrainAbnrmlyMicroscpcTyp | Type of microscopic brain abnormality identified through staining | Type of microscopic brain abnormality identified through staining | Staining methods used for tangles, plaques, Lewy Bodies, and TDP-43 | Tangles;Plaques;Lewy bodies;TDP-43 | Tangles;Plaques;Lewy bodies;TDP-43 | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08202 | Motor neuron disease indicator | MotrNrnDisInd | Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons | Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons | Motor Neuron Disease | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08178 | Subcortical arteriosclerotic leukoencephalopathy indicator | SubcortclArtrsclrtcLkecphInd | Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts | Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts | Is subcortical aeteriosclerotic leukoencephalopathy present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
White matter rarefaction confined to the immediate periventricular region (so-called periventricular capping) should not be included. Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08215 | Pathologic diagnosis or feature status | PthlgcDiagnsisFeatureStatus | Extent to which the pathologic diagnosis or feature affected the participant/subject | Extent to which the pathologic diagnosis or feature affected the participant/subject | Primary cause;Contributing cause | Primary cause;Contributing cause | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C02411 | Laterality type | LatTyp | Laterality type relative to the anatomic site of the body examined or affected | Laterality type relative to the anatomic site of the body examined or affected | What hemisphere of brain was evaluated? | Bilateral;Left;Right;N/A | Bilateral;Left;Right;Not present | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-08-28 16:08:00.453 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08156 | Specimen other postmortem indicator | SpecmnOtherPstmortemInd | Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Other banked postmortem specimen | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08190 | Lewy body type | LewyBdyTyp | Type of Lewy body assessed | Type of Lewy body assessed | Lewy body type | Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown | Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown | Alphanumeric |
Choose all that apply |
MCKEITH, I. G., DICKSON, D. W., LOWE, J., EMRE, M., O'BRIEN, J. T., FELDMAN, H., CUMMINGS, J., DUDA, J. E., LIPPA, C., PERRY, E. K., AARSLAND, D., ARAI, H., BALLARD, C. G., BOEVE, B., BURN, D. J., COSTA, D., DEL SER, T., DUBOIS, B., GALASKO, D., GAUTHIER, S., GOETZ, C. G., GOMEZ-TORTOSA, E., HALLIDAY, G., HANSEN, L. A., HARDY, J., IWATSUBO, T., KALARIA, R. N., KAUFER, D., KENNY, R. A., KORCZYN, A., KOSAKA, K., LEE, V. M., LEES, A., LITVAN, I., LONDOS, E., LOPEZ, O. L., MINOSHIMA, S., MIZUNO, Y., MOLINA, J. A., MUKAETOVA-LADINSKA, E. B., PASQUIER, F., PERRY, R. H., SCHULZ, J. B., TROJANOWSKI, J. Q. & YAMADA, M. 2005. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 1863-72. ALAFUZOFF, I., INCE, P. G., ARZBERGER, T., AL-SARRAJ, S., BELL, J., BODI, I., BOGDANOVIC, N., BUGIANI, O., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., IRONSIDE, J. W., KAVANTZAS, N., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., MEYRONET, D., MONORANU, C., PARCHI, P., PARKKINEN, L., PATSOURIS, E., ROGGENDORF, W., ROZEMULLER, A., STADELMANN-NESSLER, C., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2009a. Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol, 117, 635-52. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Multiple Pre-Defined Values Selected |
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C18742 | Pathologic diagnosis extrapyramidal movement other text | PthlgcDgnsisExtrpyrmdlMvmntOTH | The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders | Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08168 | Immunohistochemistry stain method name | ImmunhistchmstryStainMethdName | Name of staining method used for immunohistochemistry | Name of staining method used for immunohistochemistry | Immunohistorchemistry (IHC) | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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C08203 | Fuse in sarcoma abnormal pathology indicator | FusInSarcmaAbnrmlPathlgyInd | Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present | Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present | Is abnormal FUS pathology present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Choose one |
MACKENZIE, I. R., NEUMANN, M., BIGIO, E. H., CAIRNS, N. J., ALAFUZOFF, I., KRIL, J., KOVACS, G. G., GHETTI, B., HALLIDAY, G., HOLM, I. E., INCE, P. G., KAMPHORST, W., REVESZ, T., ROZEMULLER, A. J., KUMAR-SINGH, S., AKIYAMA, H., BABORIE, A., SPINA, S., DICKSON, D. W., TROJANOWSKI, J. Q. & MANN, D. M. 2010. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol, 119, 1-4. MUNOZ, D. G., NEUMANN, M., KUSAKA, H., YOKOTA, O., ISHIHARA, K., TERADA, S., KURODA, S. & MACKENZIE, I. R. 2009. FUS pathology in basophilic inclusion body disease. Acta Neuropathol, 118, 617-27. NEUMANN, M., RADEMAKERS, R., ROEBER, S., BAKER, M., KRETZSCHMAR, H. A. & MACKENZIE, I. R. 2009a. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain, 132, 2922-31. NEUMANN, M., ROEBER, S., KRETZSCHMAR, H. A., RADEMAKERS, R., BAKER, M. & MACKENZIE, I. R. 2009b. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathol, 118, 605-16. | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08179 | Cortical laminar necrosis indicator | CortclLamnrNecrsisInd | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries | Is cortical laminar necrosis present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C17398 | Specimen other postmortem text | SpecOthPostmortText | Text area to describe other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist | Description of other available banked postmortem specimens | Yes, specify | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2012-12-20 00:00:00.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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C04802 | Death date and time | DeathDateTime | Date (and time, if known) of participant's/subject's death | Date (and time, if known) of participant's/subject's death | Date of death | Date or Date & Time |
(DD/MMM/YYYY) |
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 11:38:01.2 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
2004152 | |||||||||
C08157 | Photograph macroscopic indicator | PhotographsMacroscopicInd | Indicator of whether macroscopic photographs were taken | Indicator of whether macroscopic photographs were taken | Macroscopic photographs | Yes;No;Unknown | Yes;No;Unknown | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08191 | Substantia nigral neuromelanin-containing neurons neuronal loss scale | SbstntNgrlNromlnCntnNrnLssScl | Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra | Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra | Estimate degree of substantia nigral neruomelanin-containing neuronal loss | None;Mild;Moderate;Severe;Not assessed;Unknown | None;Mild;Moderate;Severe;Not assessed;Unknown | Alphanumeric |
Choose one |
DICKSON, D. W., BRAAK, H., DUDA, J. E., DUYCKAERTS, C., GASSER, T., HALLIDAY, G. M., HARDY, J., LEVERENZ, J. B., DEL TREDICI, K., WSZOLEK, Z. K. & LITVAN, I. 2009. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol, 8, 1150-7. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18743 | Pathologic diagnosis responsible cognitive status other text | PthgcDgnsisRspCgntvStatOTH | The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status | Other, specify | Alphanumeric |
Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08169 | Antibody stain method name | AntibdyStainMethdName | Name of staining method used for antibodies | Name of staining method used for antibodies | Antibodies | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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C08204 | Frontotemporal Lobar Degeneration (FTLD) - other type indicator | FTLDOthrTypInd | Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present | Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present | Is another type of FTLD present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
If no, skip to Question 40 |
No references available | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C08180 | Medial temporal lobe sclerosis indicator | MedialTemprlLbeSclersisInd | Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures | Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures | Is medial temporal lobe sclerosis that is considered to be ischemic in nature present? | Yes;No;Unknown;Not assessed | Yes;No;Unknown;Not assessed | Alphanumeric |
In the hippocampus, this is often limited to CA1 and the subiculum with variable involvement of endplate and CA2. The amygdala and entorhinal cortex may also be affected. In some cases there is a clear history of cerebral hypoperfusion. In others there may be a history of epilepsy. Similar pathology can also be seen in the setting of neurodegenerative disorders (e.g., FTD). Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES |
No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C17400 | Other pathology ischemic vascular disease text | OthrPathlgyIschmcVasclrDisTxt | Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously | Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously | Yes, specify | Alphanumeric | No references available | Adult;Pediatric | Supplemental | 1.00 | 2012-12-20 00:00:00.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 255 |
Free-Form Entry |
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C06005 | Data collected date and time | DataCollDateTime | Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. | Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. | Date form completed | Date or Date & Time |
(DD/MMM/YYYY) |
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm | Adult;Pediatric | Supplemental | 3.00 | 2013-07-24 21:00:23.88 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
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C08158 | Brain weight measurement | BrainWgtMeasr | Weight of the participant's/subject's brain in grams | Weight of the participant's/subject's brain in grams | Record brain weight (grams) | Numeric Values | No references available | Adult;Pediatric | Supplemental | 3.00 | 2013-07-20 10:46:24.96 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Free-Form Entry |
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C08192 | Alpha-synuclein pathology type | AlphaSynuclnPathlgyTyp | Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Alpha-synuclein pathology consistent with multiple system atrophy (MSA) | Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown | Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown | Alphanumeric |
No instructions available |
LANTOS, P. L. 1998. The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol, 57, 1099-111. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |
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C18744 | Pathologic disorder other specify text | PatholgcDisordrOthrST | The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present | The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present | Other, specify | Alphanumeric |
Choose one. If YES is answered then specify the other major pathologic disorder. |
No references available | Adult;Pediatric | Supplemental | 1.00 | 2014-05-27 13:34:46.0 | Neuropathology | Other Clinical Data | Assessments and Examinations | 4000 |
Free-Form Entry |
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C08170 | Neuritic plaque density category | NeuriticPlaqDenstyCat | Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). | Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). | Neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores) | No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown | No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown | Alphanumeric | MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. | Adult | Supplemental | 3.00 | 2013-07-22 09:34:41.527 | Neuropathology | Other Clinical Data | Assessments and Examinations |
Single Pre-Defined Value Selected |