CDE Detailed Report

Disease: Parkinson's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology

Displaying 1 - 50 of 83
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C08186 Other angiopathy type indicator OthrAngpthyTypInd Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present Is another type of angiopathy (e.g., CADASIL or arteritis) present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Choose one

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18032 Other major pathologic disorder name OthrMjrPathlgcDisordrNam Names of the other major pathologic disorders present. Names of the other major pathologic disorders present. List other disorders Alphanumeric No references available Adult Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C08152 Brain tissue frozen indicator BrainTissFrozenInd Indicator of whether banked frozen brain tissue is accessible Indicator of whether banked frozen brain tissue is accessible Is banked frozen brain tissue accessible? Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08164 ADRDA Khachaturian neuropathological criteria result ADRDAKhachtrnNeuropthCritrRes ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease ADRDA/Khachaturian neuropathological critera Alzheimer's disease;Criteria not met;Not assessed;Unknown Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric KHACHATURIAN, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch Neurol, 42, 1097-105. Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08198 Tauopathy not specified incompletely characterized indicator TpthyNtSpcfdIncmpltChrctrzdInd Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized Other Tauopathies Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

Choose one

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are one or more cortical microinfarcts (including "granular atrophy") present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Infarcts meeting these criteria are included regardless of the histologic age and include acute lesions as well as chronic cystic lesions. 'Microinfarcts in non-cortical areas should not be included in this category. 'Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08211 Pathologic disorder other indicator PatholgcDisordrOthrInd Whether or not there are other major pathologic disorders that are present Whether or not there are other major pathologic disorders that are present Are other major pathologic disorders present (not addressed)? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

Choose one. If YES is answered then specify the other major pathologic disorder.

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08187 Lewy body pathology indicator LewyBdyPathlgyInd Whether or not Lewy body pathology is present Whether or not Lewy body pathology is present Is Lewy body pathology present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no,skip to Question 31

BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18667 Data source other text DataSourcOTH The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form Other, specify Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08153 Brain tissue formalin-fixed indicator BrainTissFormalinFixedInd Indicator of whether formalin-fixed brain tissue is accessible Indicator of whether formalin-fixed brain tissue is accessible Is formalin-fixed brain tissue accessible? Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08165 Other unspecific neuropathological criteria result OthrUnspcfcNeuropthCritrReslt Other or unspecified neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease Other or unspecified neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease Other or unspecified criteria Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown Alphanumeric No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08200 Abnormal TPD-43 pathology indicator AbnrmlTPD43PathlgyInd Whether or not abnormal TPD-43 pathology is present Whether or not abnormal TPD-43 pathology is present Is abnormal TDP-43 pathology present Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Choose one

CAIRNS, N. J., BIGIO, E. H., MACKENZIE, I. R., NEUMANN, M., LEE, V. M., HATANPAA, K. J., WHITE, C. L., 3RD, SCHNEIDER, J. A., GRINBERG, L. T., HALLIDAY, G., DUYCKAERTS, C., LOWE, J. S., HOLM, I. E., TOLNAY, M., OKAMOTO, K., YOKOO, H., MURAYAMA, S., WOULFE, J., MUNOZ, D. G., DICKSON, D. W., INCE, P. G., TROJANOWSKI, J. Q. & MANN, D. M. 2007. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (Berl), 114, 5-22. Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08176 Lacunes single or multiple indicator LacunesSingMultiInd Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matter Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels. Are one or more lacunes (small artery infarcts and/or hemorrhages) present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08213 Pathologic diagnosis responsible cognitive status type PthgcDgnsisRspCgntvStatTyp Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status What are the primary and contributing pathologic diagnoses or features which you judge to be responsible for the subject's cognitive status? No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Vascular disease;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Other, specify No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Vascular disease;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Other, specify Alphanumeric

Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2.

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C08188 Lewy related pathology anatomic site LewyReltPathlgyAntmicSite Brain region where Lewy body pathology was assessed Brain region where Lewy body pathology was assessed Density of "Lewy related pathology present" by regions Sympathetic ganglia (paravertebral);Parasympathetic ganglia (GI, GU);Spinal Cord;Olfactory bulb;Dorsal motor nucleus/glossopharyngeal;Locus ceruleus;Raphe;Substantia nigra;pars compacta;Amygdala;Basal nucleus/diagonal band;Hypothalamus;Caudate/putamen;Entorhinal cortex;Cingulate cortex;Hippocampus;Temporal cortex;Frontal cortex;Parietal cortex;Primary cortex (motor and/or visual) Sympathetic ganglia (paravertebral);Parasympathetic ganglia (GI, GU);Spinal Cord;Olfactory bulb;Dorsal motor nucleus/glossopharyngeal;Locus ceruleus;Raphe;Substantia nigra;pars compacta;Amygdala;Basal nucleus/diagonal band;Hypothalamus;Caudate/putamen;Entorhinal cortex;Cingulate cortex;Hippocampus;Temporal cortex;Frontal cortex;Parietal cortex;Primary cortex (motor and/or visual) Alphanumeric

No instructions available

BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18669 Diagnosis final clinical death other text DiagnosFinalClinDeathOTH The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject Other, specify Alphanumeric No references available Adult Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08154 Brain tissue paraffin-embedded indicator BrainTissParaffinEmbeddedInd Indicator of whether paraffin-embedded blocks of brain tissue are accessible Indicator of whether paraffin-embedded blocks of brain tissue are accessible Are paraffin-embedded blocks of brain tissue accessible? Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08166 Brain atrophy Braak and Braak neurofibrillary stage BrAtBraakBraakNeurofibStage Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices. Braak and Braak Neurofibrillary Stage Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown Alphanumeric

Answer 'Not Assessed' if topographic staging has not been done.

BRAAK, H. & BRAAK, E. 1991. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl), 82, 239-59. BRAAK, H. & BRAAK, E. 1997. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging, 18, 351-7. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08201 Hippocampal sclerosis indicator HippcmplSclrsisInd Whether or not the participant/subject has hippocampal sclerosis of the elderly associated with TDP-43 pathology Whether or not the participant/subject has hippocampal sclerosis of the elderly associated with TDP-43 pathology Hippocampal sclerosis of the elderly associated with TDP-43 pathology Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Choose one

AMADOR-ORTIZ, C., LIN, W. L., AHMED, Z., PERSONETT, D., DAVIES, P., DUARA, R., GRAFF-RADFORD, N. R., HUTTON, M. L. & DICKSON, D. W. 2007. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol, 61, 435-45. Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08177 Hemorrhage indicator HemrrhgInd Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Are single or multiple hemorrhages present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08214 Pathologic diagnosis extrapyramidal movement type PthlgcDgnsisExtrpyrmdlMvmntTyp Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders What are the primary and contributing pathologic diagnoses or features which you judge to be responsible for the subject's extrapyramidal movement disorders, if present? No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Vascular Parkinsonism;Idiopathic nigral degeneration;Hippocampal sclerosis;Other, specify No significant pathology;AD pathology present but insufficient for AD diagnosis;Alzheimer disease (AD);Lewy body disease;Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;FTLD-TDP;FTLD-Taupathies;Hydrocephalus;Prion-associated disease;Huntington's disease (HD);Neurodegeneration with brain iron accumulation;Vascular Parkinsonism;Idiopathic nigral degeneration;Hippocampal sclerosis;Other, specify Alphanumeric

Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2.

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C00035 Gender type GenderTyp Self-reported gender of the participant/subject. Self-reported gender of the participant/subject.. Gender Alphanumeric

Choose one. Response is obtained by report of the participant/subject or caretaker.

The NIH Guidelines on Inclusion of Women and Minorities as Subjects in Clinical Research: The Office of Management and Budget (OMB) Directive No. 15 - http://grants.nih.gov/grants/funding/women_min/women_min.htm Adult;Pediatric Core 3.00 2013-08-28 16:08:00.453 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

2200604
C08155 CSF postmortem indicator CSFPstmortemInd Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible Is banked postmortem cerebrospinal fluid accessible? Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08189 Lewy related pathology severity scale LewyReltPathlgySevrtyScale Severity of the density of "Lewy related pathology" by region Severity of the density of "Lewy related pathology" by region None, Mild, Moderate, Severe, Not assessed, Unknown None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

No instructions available

BEACH, T. G., WHITE, C. L., HAMILTON, R. L., DUDA, J. E., IWATSUBO, T., DICKSON, D. W., LEVERENZ, J. B., RONCAROLI, F., BUTTINI, M., HLADIK, C. L., SUE, L. I., NOORIGIAN, J. V. & ADLER, C. H. 2008. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol, 116, 277-88. ALAFUZOFF, I., PARKKINEN, L., AL-SARRAJ, S., ARZBERGER, T., BELL, J., BODI, I., BOGDANOVIC, N., BUDKA, H., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., KAMPHORST, W., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., LARIONOV, S., MEYRONET, D., MONORANU, C., MORRIS, J., PARCHI, P., PATSOURIS, E., ROGGENDORF, W., SEILHEAN, D., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2008. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol, 67, 125-43. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18741 Other pathology ischemic vascular disease specify text OthrPathlgyIschmcVasclrDisST The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously The free-text field related to 'Other pathology ischemic vascular disease indicator'. Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Other, specify Alphanumeric

Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08167 Brain abnormality microscopic type BrainAbnrmlyMicroscpcTyp Type of microscopic brain abnormality identified through staining Type of microscopic brain abnormality identified through staining Staining methods used for tangles, plaques, Lewy Bodies, and TDP-43 Tangles;Plaques;Lewy bodies;TDP-43 Tangles;Plaques;Lewy bodies;TDP-43 Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08202 Motor neuron disease indicator MotrNrnDisInd Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons Whether or not the participant/subject has a neurological disorder that selectively affects motor neurons Motor Neuron Disease Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Choose one

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08178 Subcortical arteriosclerotic leukoencephalopathy indicator SubcortclArtrsclrtcLkecphInd Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts Indicator of the presence of multifocal or diffuse white matter pathology attributable to arteriosclerotic small vessel disease and will be associated with axonal and myelin loss in the centrum ovale, often associated with brain infarcts Is subcortical aeteriosclerotic leukoencephalopathy present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

White matter rarefaction confined to the immediate periventricular region (so-called periventricular capping) should not be included. Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08215 Pathologic diagnosis or feature status PthlgcDiagnsisFeatureStatus Extent to which the pathologic diagnosis or feature affected the participant/subject Extent to which the pathologic diagnosis or feature affected the participant/subject Primary cause;Contributing cause Primary cause;Contributing cause Alphanumeric

Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2.

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C02411 Laterality type LatTyp Laterality type relative to the anatomic site of the body examined or affected Laterality type relative to the anatomic site of the body examined or affected What hemisphere of brain was evaluated? Bilateral;Left;Right;N/A Bilateral;Left;Right;Not present Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08156 Specimen other postmortem indicator SpecmnOtherPstmortemInd Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Other banked postmortem specimen Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08190 Lewy body type LewyBdyTyp Type of Lewy body assessed Type of Lewy body assessed Lewy body type Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown Brainstem predominant type;Intermediate or transitional (limbic) type;Diffuse (neocortical) type;Amygdala predominant;Lewy body pathology, unspecified or not further assessed;Not assessed;Missing/Unknown Alphanumeric

Choose all that apply

MCKEITH, I. G., DICKSON, D. W., LOWE, J., EMRE, M., O'BRIEN, J. T., FELDMAN, H., CUMMINGS, J., DUDA, J. E., LIPPA, C., PERRY, E. K., AARSLAND, D., ARAI, H., BALLARD, C. G., BOEVE, B., BURN, D. J., COSTA, D., DEL SER, T., DUBOIS, B., GALASKO, D., GAUTHIER, S., GOETZ, C. G., GOMEZ-TORTOSA, E., HALLIDAY, G., HANSEN, L. A., HARDY, J., IWATSUBO, T., KALARIA, R. N., KAUFER, D., KENNY, R. A., KORCZYN, A., KOSAKA, K., LEE, V. M., LEES, A., LITVAN, I., LONDOS, E., LOPEZ, O. L., MINOSHIMA, S., MIZUNO, Y., MOLINA, J. A., MUKAETOVA-LADINSKA, E. B., PASQUIER, F., PERRY, R. H., SCHULZ, J. B., TROJANOWSKI, J. Q. & YAMADA, M. 2005. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 1863-72. ALAFUZOFF, I., INCE, P. G., ARZBERGER, T., AL-SARRAJ, S., BELL, J., BODI, I., BOGDANOVIC, N., BUGIANI, O., FERRER, I., GELPI, E., GENTLEMAN, S., GIACCONE, G., IRONSIDE, J. W., KAVANTZAS, N., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., MEYRONET, D., MONORANU, C., PARCHI, P., PARKKINEN, L., PATSOURIS, E., ROGGENDORF, W., ROZEMULLER, A., STADELMANN-NESSLER, C., STREICHENBERGER, N., THAL, D. R. & KRETZSCHMAR, H. 2009a. Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol, 117, 635-52. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C18742 Pathologic diagnosis extrapyramidal movement other text PthlgcDgnsisExtrpyrmdlMvmntOTH The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders The free-text field related to 'Pathologic diagnosis extrapyramidal movement type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's extrapyrimidal movement disorders Other, specify Alphanumeric

Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2.

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08168 Immunohistochemistry stain method name ImmunhistchmstryStainMethdName Name of staining method used for immunohistochemistry Name of staining method used for immunohistochemistry Immunohistorchemistry (IHC) Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C08203 Fuse in sarcoma abnormal pathology indicator FusInSarcmaAbnrmlPathlgyInd Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present Indicator of whether abnormal fused in sarcoma (FUS) protein pathology is present Is abnormal FUS pathology present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Choose one

MACKENZIE, I. R., NEUMANN, M., BIGIO, E. H., CAIRNS, N. J., ALAFUZOFF, I., KRIL, J., KOVACS, G. G., GHETTI, B., HALLIDAY, G., HOLM, I. E., INCE, P. G., KAMPHORST, W., REVESZ, T., ROZEMULLER, A. J., KUMAR-SINGH, S., AKIYAMA, H., BABORIE, A., SPINA, S., DICKSON, D. W., TROJANOWSKI, J. Q. & MANN, D. M. 2010. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol, 119, 1-4. MUNOZ, D. G., NEUMANN, M., KUSAKA, H., YOKOTA, O., ISHIHARA, K., TERADA, S., KURODA, S. & MACKENZIE, I. R. 2009. FUS pathology in basophilic inclusion body disease. Acta Neuropathol, 118, 617-27. NEUMANN, M., RADEMAKERS, R., ROEBER, S., BAKER, M., KRETZSCHMAR, H. A. & MACKENZIE, I. R. 2009a. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain, 132, 2922-31. NEUMANN, M., ROEBER, S., KRETZSCHMAR, H. A., RADEMAKERS, R., BAKER, M. & MACKENZIE, I. R. 2009b. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathol, 118, 605-16. Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08179 Cortical laminar necrosis indicator CortclLamnrNecrsisInd Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries Indicator of the presence of selective cortical necrosis of middle and lower cortical lamina most often associated with cerebral hypoperfusion and concentrated in border zones between major cerebral arteries Is cortical laminar necrosis present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17398 Specimen other postmortem text SpecOthPostmortText Text area to describe other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Description of other available banked postmortem specimens Yes, specify Alphanumeric Adult;Pediatric Supplemental 1.00 2012-12-20 00:00:00.0 Neuropathology Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C04802 Death date and time DeathDateTime Date (and time, if known) of participant's/subject's death Date (and time, if known) of participant's/subject's death Date of death Date or Date & Time

(DD/MMM/YYYY)

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult;Pediatric Supplemental 3.00 2013-07-24 11:38:01.2 Neuropathology Other Clinical Data Assessments and Examinations

Free-Form Entry

2004152
C08157 Photograph macroscopic indicator PhotographsMacroscopicInd Indicator of whether macroscopic photographs were taken Indicator of whether macroscopic photographs were taken Macroscopic photographs Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08191 Substantia nigral neuromelanin-containing neurons neuronal loss scale SbstntNgrlNromlnCntnNrnLssScl Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra Extent of neuronal loss (neuromelanin-containing neurons) in substantia nigra Estimate degree of substantia nigral neruomelanin-containing neuronal loss None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

Choose one

DICKSON, D. W., BRAAK, H., DUDA, J. E., DUYCKAERTS, C., GASSER, T., HALLIDAY, G. M., HARDY, J., LEVERENZ, J. B., DEL TREDICI, K., WSZOLEK, Z. K. & LITVAN, I. 2009. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol, 8, 1150-7. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18743 Pathologic diagnosis responsible cognitive status other text PthgcDgnsisRspCgntvStatOTH The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status The free-text field related to 'Pathologic diagnosis responsible cognitive status type' specifying other text. Type of pathologic diagnosis or feature which is assessed for its relationship to the participant's/subject's cognitive status Other, specify Alphanumeric

Code the primary diagnoses or features with a 1. Code the contributing diagnoses or features with a 2.

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08169 Antibody stain method name AntibdyStainMethdName Name of staining method used for antibodies Name of staining method used for antibodies Antibodies Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C08204 Frontotemporal Lobar Degeneration (FTLD) - other type indicator FTLDOthrTypInd Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present Is another type of FTLD present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no, skip to Question 40

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08180 Medial temporal lobe sclerosis indicator MedialTemprlLbeSclersisInd Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures Is medial temporal lobe sclerosis that is considered to be ischemic in nature present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

In the hippocampus, this is often limited to CA1 and the subiculum with variable involvement of endplate and CA2. The amygdala and entorhinal cortex may also be affected. In some cases there is a clear history of cerebral hypoperfusion. In others there may be a history of epilepsy. Similar pathology can also be seen in the setting of neurodegenerative disorders (e.g., FTD). Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17400 Other pathology ischemic vascular disease text OthrPathlgyIschmcVasclrDisTxt Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Yes, specify Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2012-12-20 00:00:00.0 Neuropathology Other Clinical Data Assessments and Examinations 255

Free-Form Entry

C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date form completed Date or Date & Time

(DD/MMM/YYYY)

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult;Pediatric Supplemental 3.00 2013-07-24 21:00:23.88 Neuropathology Other Clinical Data Assessments and Examinations

Free-Form Entry

C08158 Brain weight measurement BrainWgtMeasr Weight of the participant's/subject's brain in grams Weight of the participant's/subject's brain in grams Record brain weight (grams) Numeric Values No references available Adult;Pediatric Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations

Free-Form Entry

gram
C08192 Alpha-synuclein pathology type AlphaSynuclnPathlgyTyp Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) Alpha-synuclein pathology consistent with multiple system atrophy (MSA) Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown Alphanumeric

No instructions available

LANTOS, P. L. 1998. The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol, 57, 1099-111. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18744 Pathologic disorder other specify text PatholgcDisordrOthrST The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present Other, specify Alphanumeric

Choose one. If YES is answered then specify the other major pathologic disorder.

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08170 Neuritic plaque density category NeuriticPlaqDenstyCat Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). Neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores) No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown Alphanumeric MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

CSV