CDE Detailed Report

Disease: Parkinson's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology

Displaying 1 - 50 of 83
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C08204 Frontotemporal Lobar Degeneration (FTLD) - other type indicator FTLDOthrTypInd Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present Whether another type of Frontotemporal Lobar Degeneration (FTLD) is present Is another type of FTLD present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no, skip to Question 40

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08169 Antibody stain method name AntibdyStainMethdName Name of staining method used for antibodies Name of staining method used for antibodies Antibodies Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

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C17400 Other pathology ischemic vascular disease text OthrPathlgyIschmcVasclrDisTxt Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Text field to describe the presence of another ischemic or vascular disease not specifically mentioned previously Yes, specify Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2012-12-20 00:00:00.0 Neuropathology Other Clinical Data Assessments and Examinations 255

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C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date form completed Date or Date & Time

(DD/MMM/YYYY)

ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult;Pediatric Supplemental 3.00 2013-07-24 21:00:23.88 Neuropathology Other Clinical Data Assessments and Examinations

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C08180 Medial temporal lobe sclerosis indicator MedialTemprlLbeSclersisInd Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures Indicator of the presence of selective neuronal loss and gliosis (sclerosis) of medial temporal lobe structures Is medial temporal lobe sclerosis that is considered to be ischemic in nature present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

In the hippocampus, this is often limited to CA1 and the subiculum with variable involvement of endplate and CA2. The amygdala and entorhinal cortex may also be affected. In some cases there is a clear history of cerebral hypoperfusion. In others there may be a history of epilepsy. Similar pathology can also be seen in the setting of neurodegenerative disorders (e.g., FTD). Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18744 Pathologic disorder other specify text PatholgcDisordrOthrST The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present The free-text field related to 'Pathologic disorder other indicator'. Whether or not there are other major pathologic disorders that are present Other, specify Alphanumeric

Choose one. If YES is answered then specify the other major pathologic disorder.

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08158 Brain weight measurement BrainWgtMeasr Weight of the participant's/subject's brain in grams Weight of the participant's/subject's brain in grams Record brain weight (grams) Numeric Values No references available Adult;Pediatric Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations

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gram
C08192 Alpha-synuclein pathology type AlphaSynuclnPathlgyTyp Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) Type of alpha-synuclein pathology consistent with multiple system atrophy (MSA) Alpha-synuclein pathology consistent with multiple system atrophy (MSA) Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown Striatonigral predominant;Olivopontocerebellar predominant;Mixed striatonigral and olivopontocerebellar;MSA (not specified or incompletely characterized);Not assessed;Unknown Alphanumeric

No instructions available

LANTOS, P. L. 1998. The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol, 57, 1099-111. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08205 Frontotemporal Lobar Degeneration (FTLD) - type FTLDTyp Types of Frontotemporal Lobar Degeneration (FTLD) assessed Types of Frontotemporal Lobar Degeneration (FTLD) assessed FTLD-OTHER FTLD-UPS (ubiquitin-positive inclusions, but tau, TDP-43 and FUS negative);FTLD-NI (No inclusion);FTLD-NOS (Not otherwise specific or incompletely characterized) FTLD-UPS (ubiquitin-positive inclusions, but tau, TDP-43 and FUS negative);FTLD-NI (No inclusion);FTLD-NOS (Not otherwise specific or incompletely characterized) Alphanumeric

Answered only if Question 39 (Is another type of FTLD present?) is answered YES. For each type of FTLD indicate whether it is present.

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08170 Neuritic plaque density category NeuriticPlaqDenstyCat Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores). Neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores) No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown Alphanumeric MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17407 Tauopathy not specified or incompletely characterized text TauNotSpeIncomChTxt Text field for a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain not specified or completely described. Text field for a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain not specified or completely described. Alphanumeric No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

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C08147 Data source DataSource Source of the data provided on the case report form Source of the data provided on the case report form Data Source Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C08181 Other pathology ischemic vascular disease indicator OthrPathlgyIschmcVasclrDisInd Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Indicator of the presence of another ischemic or vascular disease not specifically mentioned previously Is there other pathology related to ischemic or vascular disease not previously specified present? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18746 Prion disease other specify text PrionDisOthrST The free-text field related to 'Prion disease other indicator'. Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present The free-text field related to 'Prion disease other indicator'. Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present Yes, specify Alphanumeric

Answered only if Question 40 (Is there pathology consistent with transmissible spongiform encephalopathy?) is answered YES. Choose one. If YES is answered then specify the other prion disease.

No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

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C08160 Brain tissue weigh type BrainTissWeighedTyp Type of brain tissue weighed Type of brain tissue weighed Type of tissue weighed Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08193 Spinocerebellar degeneration indicator SpinocrblrDegnrtnInd Indicator of whether the participant/subject has spinocerebellar degenerations Indicator of whether the participant/subject has spinocerebellar degenerations Spinocerebellar degenerations Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

No instructions available

GWINN-HARDY, K., CHEN, J. Y., LIU, H. C., LIU, T. Y., BOSS, M., SELTZER, W., ADAM, A., SINGLETON, A., KOROSHETZ, W., WATERS, C., HARDY, J. & FARRER, M. 2000. Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese. Neurology, 55, 800-5. GWINN-HARDY, K., SINGLETON, A., O'SUILLEABHAIN, P., BOSS, M., NICHOLL, D., ADAM, A., HUSSEY, J., CRITCHLEY, P., HARDY, J. & FARRER, M. 2001. Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family. Arch Neurol, 58, 296-9. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08206 Frontotemporal Lobar Degeneration (FTLD) - type indicator FTLDTypInd Whether the specific type of FTLD is present Whether the specific type of FTLD is present Is another type of FTLD present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Answered only if Question 39 (Is another type of FTLD present?) is answered YES.

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08171 Diffuse plaques density category DiffusePlaqDenstyCat Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Diffuse Plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown Alphanumeric

Choose one

MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479-86. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C17423 Spinocerebellar degeneration type text SpinDegTypTxt Text area to describe the type of spinocerebellar degenerations Text area to describe the type of spinocerebellar degenerations Alphanumeric No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

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C08148 Neuropath specimen identifier number NeuropthSpecmnIDNum Unique identification number given to the neuropathology specimen Unique identification number given to the neuropathology specimen Neuropath ID Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations 255

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C08183 Atherosclerotic vascular pathology severity scale AthrsclrtcVasclrPthlgySvrtyScl Whether or not atherosclerotic vascular pathology (of the circle of Willis) is present and if so, its severity Whether or not atherosclerotic vascular pathology (of the circle of Willis) is present and if so, its severity Is atherosclerotic vascular pathology (of the circle of Willis) present? None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

Choose one

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18754 Spinocerebellar degeneration specify text SpinocrblrDegnrtnST The free-text field related to 'Spinocerebellar degeneration indicator specify text'. Indicator of whether the participant/subject has spinocerebellar degenerations The free-text field related to 'Spinocerebellar degeneration indicator specify text'. Indicator of whether the participant/subject has spinocerebellar degenerations Yes, specify Alphanumeric

No instructions available

GWINN-HARDY, K., CHEN, J. Y., LIU, H. C., LIU, T. Y., BOSS, M., SELTZER, W., ADAM, A., SINGLETON, A., KOROSHETZ, W., WATERS, C., HARDY, J. & FARRER, M. 2000. Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese. Neurology, 55, 800-5. GWINN-HARDY, K., SINGLETON, A., O'SUILLEABHAIN, P., BOSS, M., NICHOLL, D., ADAM, A., HUSSEY, J., CRITCHLEY, P., HARDY, J. & FARRER, M. 2001. Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family. Arch Neurol, 58, 296-9. Adult Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08161 Hydrocephalus severity scale HydrcephlsSevrtyScale Scale of the severity of the hydrocephalus Scale of the severity of the hydrocephalus Hydrocephalus None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08195 Frontotemporal degeneration tau pathology indicator FrntmprlDgnrtnTauPathlgyInd Indicator of whether frontotemporal degeneration with tau pathology is present Indicator of whether frontotemporal degeneration with tau pathology is present Is frontotemporal degeneration with tau pathology present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no, skip to Question 35

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08207 Transmissible spongiform encephalopathy indicator TransmssblSpngfrmEncphlpthyInd Whether or not pathology is consistent with transmissible spongiform encephalopathy Whether or not pathology is consistent with transmissible spongiform encephalopathy Is there a pathology consistent with transmissible spongiform encephalopathy Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no, skip to Question 41

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08172 Beta-amyloidal plaque accumulation stage BetaAmyldlPlaqAccmltnStage Extent of beta-amyloidal plaque accumulation through the brain Extent of beta-amyloidal plaque accumulation through the brain Amyloid phase Phase I (cortex);Phase 2 (cortex and hippocampus);Phase 3 (cortex, hippocampus, and basal ganglia);Phase 4 (cortex, hippocampus, basal ganglia, and brainstem);Phase 5 (cortex, hippocampus, basal ganglia, brainstem, and cerebellum);Amyloid plaques not present;Incompletely assessed;Not assessed;Unknown Phase I (cortex);Phase 2 (cortex and hippocampus);Phase 3 (cortex, hippocampus, and basal ganglia);Phase 4 (cortex, hippocampus, basal ganglia, and brainstem);Phase 5 (cortex, hippocampus, basal ganglia, brainstem, and cerebellum);Amyloid plaques not present;Incompletely assessed;Not assessed;Unknown Alphanumeric

Choose one

ALAFUZOFF, I., THAL, D. R., ARZBERGER, T., BOGDANOVIC, N., AL-SARRAJ, S., BODI, I., BOLUDA, S., BUGIANI, O., DUYCKAERTS, C., GELPI, E., GENTLEMAN, S., GIACCONE, G., GRAEBER, M., HORTOBAGYI, T., HOFTBERGER, R., INCE, P., IRONSIDE, J. W., KAVANTZAS, N., KING, A., KORKOLOPOULOU, P., KOVACS, G. G., MEYRONET, D., MONORANU, C., NILSSON, T., PARCHI, P., PATSOURIS, E., PIKKARAINEN, M., REVESZ, T., ROZEMULLER, A., SEILHEAN, D., SCHULZ-SCHAEFFER, W., STREICHENBERGER, N., WHARTON, S. B. & KRETZSCHMAR, H. 2009b. Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol, 117, 309-20. THAL, D. R., RUB, U., ORANTES, M. & BRAAK, H. 2002. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology, 58, 1791-800. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18030 Neuritic plaque brain region score anatomic site NeurtcPlaqBrnRegnScoreAnatcSit The anatomic site as it relates to the region in the brain where the neuritic plaques were scored The anatomic site as it relates to the region in the brain where the neuritic plaques were scored Region of brain neuritic plaques scored Left;Right;Both;N/A Left;Right;Both;N/A Alphanumeric No references available Adult Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08149 Diagnosis final clinical death type DiagnosFinalClinDeathTyp Physician's final clinical diagnosis for the participant/subject Physician's final clinical diagnosis for the participant/subject Final Clinical Diagnosis Before Death Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Alphanumeric No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Multiple Pre-Defined Values Selected

C08184 Arteriosclerosis severity scale ArtrScalersisSevScl Whether or not arteriosclerosis (small parenchymal arteriolar disease) is present and if so, its severity Whether or not arteriosclerosis (small parenchymal arteriolar disease) is present and if so, its severity Is arteriosclerosis (small parenchymal arteriolar disease) present? None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

Choose one

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18766 Tauopathy not specified incompletely characterized specify text TpthyNtSpcfdIncmpltChrctrzdST The free-text field related to 'Tauopathy not specified incompletely characterized indicator'. Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized The free-text field related to 'Tauopathy not specified incompletely characterized indicator'. Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized Yes, specify Alphanumeric

Choose one

No references available Adult Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

Free-Form Entry

C08162 National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale NIAReaganInNeuropathCritScale National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. NIA/Reagan Institute neuropathological criteria Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Unknown Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric HYMAN, B. T. & TROJANOWSKI, J. Q. 1997. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08196 Tauopathy disease type TaupthyDisTyp Presence of disease resulting from the pathological aggregation of tau protein Presence of disease resulting from the pathological aggregation of tau protein Tauopathies Pick's Disease;Corticobasal degeneration;Progressive supranuclear palsy;Argyrophilic grain dementia (including diffuse AGD);Other 4R tauopathy (e.g., multisystem tauopathy);Tangle-predominant dementia (including Parkinson dementia complex) Pick's Disease;Corticobasal degeneration;Progressive supranuclear palsy;Argyrophilic grain dementia (including diffuse AGD);Other 4R tauopathy (e.g., multisystem tauopathy);Tangle-predominant dementia (including Parkinson dementia complex) Alphanumeric

No instructions available

DICKSON, D. W. 1998. Pick's disease: a modern approach. Brain Pathol, 8, 339-54. DICKSON, D. W., BERGERON, C., CHIN, S. S., DUYCKAERTS, C., HOROUPIAN, D., IKEDA, K., JELLINGER, K., LANTOS, P. L., LIPPA, C. F., MIRRA, S. S., TABATON, M., VONSATTEL, J. P., WAKABAYASHI, K. & LITVAN, I. 2002. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol, 61, 935-46. LANTOS, P. L. 1994. The neuropathology of progressive supranuclear palsy. J Neural Transm Suppl, 42, 137-52. TOLNAY, M. & CLAVAGUERA, F. 2004. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology, 24, 269-83. BIGIO, E. H., LIPTON, A. M., YEN, S. H., HUTTON, M. L., BAKER, M., NACHARAJU, P., WHITE, C. L., 3RD, DAVIES, P., LIN, W. & DICKSON, D. W. 2001. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. J Neuropathol Exp Neurol, 60, 328-41. KOVACS, G. G., MAJTENYI, K., SPINA, S., MURRELL, J. R., GELPI, E., HOFTBERGER, R., FRASER, G., CROWTHER, R. A., GOEDERT, M., BUDKA, H. & GHETTI, B. 2008. White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol, 67, 963-75. JELLINGER, K. A. & BANCHER, C. 1998. Senile dementia with tangles (tangle predominant form of senile dementia). Brain Pathol, 8, 367-76. HOF, P. R., PERL, D. P., LOERZEL, A. J. & MORRISON, J. H. 1991. Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease. Brain Res, 564, 306-13. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08209 Creutzfeldt-Jakob disease variant indicator CrtzfldtJkbDisVarntInd Whether or not Creutzfeldt-Jakob disease (CJD) or variant CJD is present Whether or not Creutzfeldt-Jakob disease (CJD) or variant CJD is present Is Creutzfeldt-Jakob disease or variant CJD present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Answered only if Question 40 (Is there pathology consistent with transmissible spongiform encephalopathy?) is answered YES.

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08173 Ischemic hemorrhagic or vascular pathology indicator IschHemVasclPathInd Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Is ischemic, hemorrhagic or vascular pathology present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If no,skip to Question 24

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18031 Diffuse plaques brain region score anatomic site DiffsePlaqBrainRgnScorAntmSite The anatomic site as it relates to the region in the brain where the diffuse plaques were scored The anatomic site as it relates to the region in the brain where the diffuse plaques were scored Region of brain diffuse plaques scored Left;Right;Both;N/A Left;Right;Both;N/A Alphanumeric No references available Adult Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08151 Diagnosis final clinical death date DiagnosFinalClinDeathDate Date of participant's/subject's final clinical diagnosis Date of participant's/subject's final clinical diagnosis Date of final diagnosis Date or Date & Time ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Free-Form Entry

C08185 Amyloid angiopathy severity scale AmyldAngpthySevScale Whether or not amyloid deposits are present in the walls of the blood vessels of the central nervous system and if so, their severity. Whether or not amyloid deposits are present in the walls of the blood vessels of the central nervous system and if so, their severity. Is amyloid angiopathy present? None;Mild;Moderate;Severe;Not assessed;Unknown None;Mild;Moderate;Severe;Not assessed;Unknown Alphanumeric

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No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C19247 Subject ID SubIDNam Subject identification ID Subject identification ID MDS/UDS Patient ID Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2014-06-05 13:10:49.0 Neuropathology Other Clinical Data Assessments and Examinations 255

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C08163 CERAD neuropathological criteria scale CERADNeuropathCritScale CERAD neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease CERAD neuropathological criteria Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropath Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C08197 Tauopathy degeneration indicator TaupthyDegnrtnInd Indicator of whether degeneration was assessed for the specific type of Tauopathy disease Indicator of whether degeneration was assessed for the specific type of Tauopathy disease Yes, No, Not assessed, Unknown Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Answer for each type of taupathy if Question 34 (Is frontotemporal degeneration with tau pathology present?) is answered YES

DICKSON, D. W. 1998. Pick's disease: a modern approach. Brain Pathol, 8, 339-54. DICKSON, D. W., BERGERON, C., CHIN, S. S., DUYCKAERTS, C., HOROUPIAN, D., IKEDA, K., JELLINGER, K., LANTOS, P. L., LIPPA, C. F., MIRRA, S. S., TABATON, M., VONSATTEL, J. P., WAKABAYASHI, K. & LITVAN, I. 2002. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol, 61, 935-46. LANTOS, P. L. 1994. The neuropathology of progressive supranuclear palsy. J Neural Transm Suppl, 42, 137-52. TOLNAY, M. & CLAVAGUERA, F. 2004. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology, 24, 269-83. BIGIO, E. H., LIPTON, A. M., YEN, S. H., HUTTON, M. L., BAKER, M., NACHARAJU, P., WHITE, C. L., 3RD, DAVIES, P., LIN, W. & DICKSON, D. W. 2001. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. J Neuropathol Exp Neurol, 60, 328-41. KOVACS, G. G., MAJTENYI, K., SPINA, S., MURRELL, J. R., GELPI, E., HOFTBERGER, R., FRASER, G., CROWTHER, R. A., GOEDERT, M., BUDKA, H. & GHETTI, B. 2008. White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol, 67, 963-75. JELLINGER, K. A. & BANCHER, C. 1998. Senile dementia with tangles (tangle predominant form of senile dementia). Brain Pathol, 8, 367-76. HOF, P. R., PERL, D. P., LOERZEL, A. J. & MORRISON, J. H. 1991. Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease. Brain Res, 564, 306-13. Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C08210 Prion disease other indicator PrionDisOthrInd Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present Whether or not another prion disease (besides Creutzfeldt-Jakob disease or variant CJD) is present Are other prion diseases present (e.g., Gerstmann-Straussler syndrome)? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

Answered only if Question 40 (Is there pathology consistent with transmissible spongiform encephalopathy?) is answered YES. Choose one. If YES is answered then specify the other prion disease.

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C08174 Large artery cerebral infarct indicator LrgArtryCerbrlInfarcInd Indicator of the presence of one or more infarcts larger than 1 cm in diameter in the distribution of large and medium sized meningocerebral vessels rather than small parenchymal vessels Indicator of the presence of one or more infarcts larger than 1 cm in diameter in the distribution of large and medium sized meningocerebral vessels rather than small parenchymal vessels Are on ore more large artery cerebral infarcts present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Infarcts meeting these criteria are included regardless of the histologic age and include acute lesions as well as chronic cystic lesions 'Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C18032 Other major pathologic disorder name OthrMjrPathlgcDisordrNam Names of the other major pathologic disorders present. Names of the other major pathologic disorders present. List other disorders Alphanumeric No references available Adult Supplemental 3.00 2013-07-20 10:46:24.96 Neuropathology Other Clinical Data Assessments and Examinations 255

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C08152 Brain tissue frozen indicator BrainTissFrozenInd Indicator of whether banked frozen brain tissue is accessible Indicator of whether banked frozen brain tissue is accessible Is banked frozen brain tissue accessible? Yes;No;Unknown Yes;No;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C08186 Other angiopathy type indicator OthrAngpthyTypInd Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present Whether or not another type of angiopathy (e.g., CADASIL or arteritis) is present Is another type of angiopathy (e.g., CADASIL or arteritis) present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

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C08164 ADRDA Khachaturian neuropathological criteria result ADRDAKhachtrnNeuropthCritrRes ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease ADRDA/Khachaturian neuropathological critera Alzheimer's disease;Criteria not met;Not assessed;Unknown Alzheimer's disease;Criteria not met;Not assessed;Unknown Alphanumeric KHACHATURIAN, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch Neurol, 42, 1097-105. Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C08198 Tauopathy not specified incompletely characterized indicator TpthyNtSpcfdIncmpltChrctrzdInd Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized Whether or not there participant/subject has an tauopathy that is not specified or incompletely characterized Other Tauopathies Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

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C08211 Pathologic disorder other indicator PatholgcDisordrOthrInd Whether or not there are other major pathologic disorders that are present Whether or not there are other major pathologic disorders that are present Are other major pathologic disorders present (not addressed)? Yes, specify;No;Not assessed;Unknown Yes, specify;No;Not assessed;Unknown Alphanumeric

Choose one. If YES is answered then specify the other major pathologic disorder.

No references available Adult;Pediatric Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are one or more cortical microinfarcts (including "granular atrophy") present? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Infarcts meeting these criteria are included regardless of the histologic age and include acute lesions as well as chronic cystic lesions. 'Microinfarcts in non-cortical areas should not be included in this category. 'Only answered if Question 23 (Is ischemic, hemorrhagic or vascular pathology present?) was answered YES

No references available Adult Supplemental 3.00 2013-07-22 09:34:41.527 Neuropathology Other Clinical Data Assessments and Examinations

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C18667 Data source other text DataSourcOTH The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form Other, specify Alphanumeric No references available Adult;Pediatric Supplemental 1.00 2014-05-27 13:34:46.0 Neuropathology Other Clinical Data Assessments and Examinations 4000

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