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NINDS CDE Notice of Copyright
Lille Apathy Rating Scale (LARS)
Availability
This instrument is available in English as a supplement to the paper (Sockeel et al., 2006): Lille Apathy Rating Scale. Additional versions are freely available for non-profit research: LARS.
Classification
Supplemental: Parkinson’s Disease (PD)
Short Description of Instrument
The Lille Apathy Rating Scale (LARS) is a structured, standardized interview questionnaire designed to distinguish between the various features of apathy. It allows detection of the syndrome and assessment of symptoms severity. Several versions of the scale have been validated: originally, a version based on an interview with the patient (Sockeel et al., 2006), one based on an interview with an informant for patients with cognitive disorders or unaware of their symptoms (LARS-i). A short form (sf-LARS) was also validated for screening apathy in everyday practice (Dujardin et al., 2013).
Comments
The LARS was created from the theoretical basis of the Marin’s apathy evaluation scale (AES). It is a 33-item questionnaire divided into nine domains. Eight of the domains focus on the clinical manifestations of apathy, which is described as reduction in everyday productivity; lack of interest; lack of initiative; extinction of novelty seeking and motivation; blunting of emotional responses; lack of concern; and poor social life. The ninth domain focuses on extinction of self awareness (Sockeel et al., 2006).
 
The LARS is in good agreement with the criteria for clinical diagnosis of apathy (Robert et al., 2009).
 
Administration takes about 10 minutes for the complete version and 5 minutes for the short-form scale
 
The LARS is available in different languages (see http://www.u1171-lille.fr/notre-recherche/lars-scale/)
Scoring
The first three questions of the questionnaire are coded on a five-point Likerttype scale (2,1,0,-1,-2). Other questions have a binary quotation. The nine domains are evaluated through subscales which contribute equal weight to the global score. The global score ranges from -36 to +36 with higher scores representing greater degrees of apathy (Sockeel et al., 2006). In Parkinson’s disease, the cut-off scores are -22/-21 for mild, -17/-16 for moderate and - 10/-9 for severe apathy
References
Dujardin K, Sockeel P, Carette AS, Delliaux M, Defebvre L. Assessing apathy in everyday clinical practice with the short-form Lille Apathy Rating Scale. Mov Disord. 2013;28(14):2014–2019.
 
Dujardin K, Sockeel P, Delliaux M, Destee A, Defebvre L. The Lille Apathy Rating Scale: validation of a caregiver-based version. Mov Disord. 2008;23(6):845–849.
 
Robert P, Onyike CU, Leentjens AF, Dujardin K, Aalten P, Starkstein S, Verhey FR, Yessavage J, Clement JP, Drapier D, Bayle F, Benoit M, Boyer P, Lorca PM, Thibaut F, Gauthier S, Grossberg G, Vellas B, Byrne J. Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. Eur Psychiatry. 2009;24(2):98–104.
 
Sockeel P, Dujardin K, Devos D, Deneve C, Destee A, Defebvre L. The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson’s disease. J Neurol Neurosurg Psych. 2006;77:579–584
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