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NINDS CDE Notice of Copyright
Maximum Voluntary Isometric Contraction Testing (MVICT)
Availability
The instrument is freely available here:
 
Classification
Supplemental-Highly Recommended: Facioscapulohumeral Muscular Dystrophy (FSHD)
 
Supplemental: Amyotrophic Lateral Sclerosis, (ALS), Cerebral Palsy (CP), Congenital Muscular Dystrophy (CMD), Duchenne Muscular Dystrophy (DMD), Mitochondrial Disease (Mito), Myotonic Dystrophy (DM), Neuromuscular Disease (NMD), Spinal Muscular Atrophy (SMA)
Short Description of Instrument
The Maximum Voluntary Isometric Contraction Testing (MVICT) uses a digital force transducer to test isometric force utilizing standardized positions to isolate individual muscles. An inelastic strap is attached to the patient's arm or leg and connected to a force transducer, and fixed metal frame. The quality of testing is greatly dependent on training of the evaluators who follow a detailed, standardized written testing protocol as well as photographs that illustrate patient position, strap placement, examiner fixation, and common substitutions will be used by the evaluators to ensure standardization of testing.
Scoring
Each muscle is tested twice while the patient is encouraged by the evaluator to exert maximal effort. The maximum force generated by the patient is recorded for each trial, and the maximum over the two trials is used as the final measurement for each muscle.
 
MVICT testing can be measured in Newtons, kilogram-force or pounds-force.
References
Andres PL, Hedlund W, Finison L, Conlon T, Felmus M, Munsat TL. Quantitative motor assessment in amyotrophic lateral sclerosis. Neurol. 1986;36(7):937–941.
 
FSH-DY Group. Randomized pilot trial of high-dose betaINF-1a in patients with inclusion body myositis. Neurol. 2004;63(4):718–720.
 
Personius KE, Pandya S, King WM, Tawil R, McDermott MP. Facioscapulohumeral dystrophy natural history study: standardization of testing procedures and reliability of measurements. The FSH DY Group. Phys Ther. 1994;74(3):253–263.
 
MVICT Observational Study in FSHD:
 
FSH-DY Group. A prospective, quantitative study of the natural history of facioscapulohumeral muscular dystrophy (FSHD): implications for therapeutic trials. The FSH-DY Group. Neurol. 1997;48(1):38–46.
 
MVICT in Clinical Trials:
 
Kissel JT, McDermott MP, Mendell JR, King WM, Pandya S, Griggs RC, Tawil R. Randomized, double-blind, placebo-controlled trial of albuterol in facioscapulohumeral dystrophy. Neurol. 2001;57(8):1434–1440.
 
Payan CA, Hogrel JY, Hammouda EH, Lacomblez L, Ollivier G, Doppler V, Eymard B, Attarian S, Pouget J, Desnuelle C, Laforet P. Periodic salbutamol in facioscapulohumeral muscular dystrophy: a randomized controlled trial. Arch Phys Med Rehab. 2009;90(7):1094–1101.
 
van der Kooi EL, Vogels OJ, van Asseldonk RJ, Lindeman E, Hendriks JC, Wohlgemuth M, van der Maarel SM, Padberg GW. Strength training and albuterol in facioscapulohumeral muscular dystrophy. Neurol. 2004;63(4):702–708.
 
Wagner KR, Fleckenstein JL, Amato AA, Barohn RJ, Bushby K, Escolar DM, Flanigan KM, Pestronk A, Tawil R, Wolfe GI, Eagle M, Florence JM, King WM, Pandya S, Straub V, Juneau P, Meyers K, Csimma C, Araujo T, Allen R, Parsons SA, Wozney JM, Lavallie ER, Mendell JR. A phase I/II trial of MYO-029 in adult subjects with muscular dystrophy. Ann Neurol. 2008;63(5):561–571.
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