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CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease: Parkinson's Disease
Sub-Domain: Other Clinical Data
CRF: Neuropathology
Item count: 83 (83 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C08147
Data source
DataSource
Source of the data provided on the case report form
Data Source
Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Unknown;Spouse;Other, specify;
Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Unknown;Spouse;Other, specify;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/20/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Data source
 
Multiple Pre-Defined Values Selected
       
C18667
Data source other text
DataSourcOTH
The free-text field related to 'Data source' specifying other text. Source of the data provided on the case report form
Other, specify
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
1.0
5/27/2014
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
 
4000
Free-Form Entry
       
C19247
Subject ID
SubIDNam
Subject identification ID
MDS/UDS Patient ID
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
1.0
6/5/2014
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
 
255
Free-Form Entry
       
C06005
Data collected date and time
DataCollDateTime
Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed.
Date form completed
  
Date or Date & Time
(DD/MMM/YYYY)
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Data collected date and time
 
Free-Form Entry
       
C08148
Neuropath specimen identifier number
NeuropthSpecmnIDNum
Unique identification number given to the neuropathology specimen
Neuropath ID
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Neuropathology specimen identifier
255
Free-Form Entry
       
C00035
Gender type
GenderTyp
Self-reported gender of the participant/subject. Gender is the socially constructed identity of sex. Gender is equated with phenotypic sex. Gender may differ from the sex of an individual determined genetically.
Gender
Female;Male;Unknown;Unspecified;Not reported;
Female;Male;Unknown;Undifferentiated/Indeterminant/Intersex;Not reported;
Alphanumeric
Choose one. Response is obtained by report of the participant/subject or caretaker.
The NIH Guidelines on Inclusion of Women and Minorities as Subjects in Clinical Research: The Office of Management and Budget (OMB) Directive No. 15 - http://grants.nih.gov/grants/funding/women_min/women_min.htm
Adult;Pediatric
Core
3.0
8/28/2013
caBIG: PRSN_GENDER_TXT_TP; SCI CDEs: GENDER
Neuropathology
Other Clinical Data
Assessments and Examinations
Gender type
 
Single Pre-Defined Value Selected
     
2200604
 
C04802
Death date and time
DeathDateTime
Date (and time, if known) of participant's/subject's death
Date of death
  
Date or Date & Time
(DD/MMM/YYYY)
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Death date and time
 
Free-Form Entry
     
2004152
 
C18669
Diagnosis final clinical death other text
DiagnosFinalClinDeathOTH
The free-text field related to 'Diagnosis final clinical death type' specifying other text. Physician's final clinical diagnosis for the participant/subject
Other, specify
  
Alphanumeric
No instructions available
No references available
Adult
Supplemental
1.0
5/27/2014
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
 
4000
Free-Form Entry
       
C08149
Diagnosis final clinical death type
DiagnosFinalClinDeathTyp
Physician's final clinical diagnosis for the participant/subject
Final Clinical Diagnosis Before Death
Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Corticobasal degeneration;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Multiple system atrophy;Neuroacanthocytosis;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Pick disease;Progressive supranuclear palsy;Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Chorea gravidarum;Other, specify;
Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Corticobasal degeneration;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Multiple system atrophy;Neuroacanthocytosis;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Pick disease;Progressive supranuclear palsy;Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Chorea gravidarum;Other, specify;
Alphanumeric
No instructions available
No references available
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Diagnosis Parkinsonian final type
 
Multiple Pre-Defined Values Selected
       
C08151
Diagnosis final clinical death date
DiagnosFinalClinDeathDate
Date of participant's/subject's final clinical diagnosis
Date of final diagnosis
  
Date or Date & Time
No instructions available
ISO 8601 - http://www.iso.org/iso/iso_catalogue.htm
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Diagnosis final date and time
 
Free-Form Entry
       
C08152
Brain tissue frozen indicator
BrainTissFrozenInd
Indicator of whether banked frozen brain tissue is accessible
Is banked frozen brain tissue accessible?
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Brain tissue frozen indicator
 
Single Pre-Defined Value Selected
       
C08153
Brain tissue formalin-fixed indicator
BrainTissFormalinFixedInd
Indicator of whether formalin-fixed brain tissue is accessible
Is formalin-fixed brain tissue accessible?
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Brain tissue formalin-fixed indicator
 
Single Pre-Defined Value Selected
       
C08154
Brain tissue paraffin-embedded indicator
BrainTissParaffinEmbeddedInd
Indicator of whether paraffin-embedded blocks of brain tissue are accessible
Are paraffin-embedded blocks of brain tissue accessible?
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Brain tissue paraffin-embedded indicator
 
Single Pre-Defined Value Selected
       
C08155
CSF postmortem indicator
CSFPstmortemInd
Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible
Is banked postmortem cerebrospinal fluid accessible?
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
CSF postmortem indicator
 
Single Pre-Defined Value Selected
       
C08156
Specimen other postmortem indicator
SpecmnOtherPstmortemInd
Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist
Other banked postmortem specimen
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Specimen other postmortem indicator
 
Single Pre-Defined Value Selected
       
C17398
Specimen other postmortem text
SpecOthPostmortText
Text area to describe other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist
Yes, specify
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
1.0
12/20/2012
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Specimen other postmortem text
255
Free-Form Entry
       
C08157
Photograph macroscopic indicator
PhotographsMacroscopicInd
Indicator of whether macroscopic photographs were taken
Macroscopic photographs
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Photographs macroscopic indicator
 
Single Pre-Defined Value Selected
       
C08158
Brain weight measurement
BrainWgtMeasr
Weight of the participant's/subject's brain in grams
Record brain weight (grams)
  
Numeric Values
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/20/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Brain weight measurement
 
Free-Form Entry
  
gram
    
C02411
Laterality type
LatTyp
Laterality type relative to the anatomic site of the body examined or affected
What hemisphere of brain was evaluated?
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
8/28/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Laterality type
 
Single Pre-Defined Value Selected
       
C08160
Brain tissue weigh type
BrainTissWeighedTyp
Type of brain tissue weighed
Type of tissue weighed
Fresh whole brain;Fresh left half;Fresh right half;Fresh not available;Fixed whole brain;Fixed left half;Fixed right half;Fixed not available;Other;
Fresh whole brain;Fresh left half;Fresh right half;Fresh not available;Fixed whole brain;Fixed left half;Fixed right half;Fixed not available;Other;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Brain tissue weighed type
 
Single Pre-Defined Value Selected
       
C08161
Hydrocephalus severity scale
HydrcephlsSevrtyScale
Scale of the severity of the hydrocephalus
Hydrocephalus
None;Mild;Moderate;Severe;Not assessed;Unknown;
None;Mild;Moderate;Severe;Not assessed;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Hydrocephalus severity scale
 
Single Pre-Defined Value Selected
       
C08162
National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale
NIAReaganInNeuropathCritScale
National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease.
NIA/Reagan Institute neuropathological criteria
Low likelihood of dementia being due to Alzheimer’s disease;Intermediate likelihood of dementia being due to Alzheimer’s disease;High likelihood of dementia being due to Alzheimer’s disease;Criteria not met;Not assessed;Unknown;
Low likelihood of dementia being due to Alzheimer’s disease;Intermediate likelihood of dementia being due to Alzheimer’s disease;High likelihood of dementia being due to Alzheimer’s disease;Criteria not met;Not assessed;Unknown;
Alphanumeric
No instructions available
HYMAN, B. T. & TROJANOWSKI, J. Q. 1997. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
NIA or Reagan Institute neuropathological criteria scale
 
Single Pre-Defined Value Selected
       
C08163
CERAD neuropathological criteria scale
CERADNeuropathCritScale
CERAD neuropathological criteria used to determine the probability of the participant/subject having Alzheimer's disease
CERAD neuropathological criteria
Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer’s disease;Criteria not met;Not assessed;Unknown;
Possible Alzheimer's disease;Probable Alzheimer's disease;Definite Alzheimer’s disease;Criteria not met;Not assessed;Unknown;
Alphanumeric
No instructions available
MIRRA, S. S., HEYMAN, A., MCKEEL, D., SUMI, S. M., CRAIN, B. J., BROWNLEE, L. M., VOGEL, F. S., HUGHES, J. P., VAN BELLE, G. & BERG, L. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropath
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
CERAD neuropathological criteria scale
 
Single Pre-Defined Value Selected
       
C08164
ADRDA Khachaturian neuropathological criteria result
ADRDAKhachtrnNeuropthCritrRes
ADRDA/Khachaturian neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease
ADRDA/Khachaturian neuropathological critera
Alzheimer's disease;Criteria not met;Not assessed;Unknown;
Alzheimer's disease;Criteria not met;Not assessed;Unknown;
Alphanumeric
No instructions available
KHACHATURIAN, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch Neurol, 42, 1097-105.
Adult;Pediatric
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
ADRDA or Khachaturian neuropathological criteria result
 
Single Pre-Defined Value Selected
       
C08165
Other unspecific neuropathological criteria result
OthrUnspcfcNeuropthCritrReslt
Other or unspecified neuropathological criteria used to determine whether or not the participant/subject has Alzheimer's disease
Other or unspecified criteria
Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown;
Alzheimer's disease, unspecified;Criteria not met;Not assessed;Unknown;
Alphanumeric
No instructions available
No references available
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Other or unspecified neuropathological criteria result
 
Single Pre-Defined Value Selected
       
C08166
Brain atrophy Braak and Braak neurofibrillary stage
BrAtBraakBraakNeurofibStage
Stages I and II correspond to NFT limited to the transentorhinal/entorhinal region; Stages III and IV to limbic stages; and Stages V and VI to neocortical stages. Stage VI implies involvement of primary cortices.
Braak and Braak Neurofibrillary Stage
Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown;
Stage I;Stage II;Stage III;Stage IV;Stage V;Stage VI;Neurofibrillary degeneration not present;Not assessed;Unknown;
Alphanumeric
Answer 'Not Assessed' if topographic staging has not been done.
BRAAK, H. & BRAAK, E. 1991. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl), 82, 239-59. BRAAK, H. & BRAAK, E. 1997. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging, 18, 351-7.
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Neuropathology
Other Clinical Data
Assessments and Examinations
Braak and Braak neurofibrillary stage
 
Single Pre-Defined Value Selected
       
07-20-2019
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