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CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Sub-Domain: Sleep
CRF: Sleep Focused Study Questionnaire
Item count: 19 (19 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C17402
Site name
SiteName
The name of the site for the study
Site Name
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental–Highly Recommended
3.0
6/21/2013
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
Site name
255
Free-Form Entry
       
C19247
Subject ID
SubIDNam
Subject identification ID
Subject ID
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental–Highly Recommended
1.0
6/5/2014
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
 
255
Free-Form Entry
       
C57101
MECFS prior history sleep problem indicator
MECFSPrHstSlpPrbInd
Indicator of whether the subject had a history of sleep problems prior to MECFS
Did the subject have a history of sleep problems prior to developing ME/CFS?
Yes;No;
Yes;No;
Alphanumeric
Researchers will have to account for and / or separate out the effects of sleep disorders from the effects of ME/CFS on sleep study results
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C57102
Sleep problem diagnosis type
SlpPrbDiagTyp
Type of diagnosis for sleep problem
If yes, what was the diagnosis?
  
Alphanumeric
No instructions available
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
 
255
Free-Form Entry
       
C57103
Issue present no diagnosis type
IssPrsntNoDiagTyp
Type of issues present without diagnosis
If no diagnosis, what issues were present (i.e., sleep disturbance, early wakening, staying asleep, other specify)
  
Alphanumeric
No instructions available
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
 
255
Free-Form Entry
       
C57104
Acclimation period before study indicator
AcclmPrdBfrStdyInd
Indicator of whether there was an acclimation period (e.g. a night when subjects were set up for a polysomnography (PSG) but no official measurements (taken) or instructions given to subjects before the study began to individual subjects
Was there an acclimation period (e.g. a night when subjects were set up for polysomnography (PSG) but no official measurements taken) or instructions given to subjects before the study began for individual subjects?
Yes;No;
Yes;No;
Alphanumeric
Acclimation in this CRF is defined as a night when subjects were set up for PSG but no official measurements taken. Without an acclimation periods, results from PSG could be a reflection of study participants' adaptation to PSG rather than effects of the ME/CFS itself. Instructions given before a sleep study may also impact results. For example, some researchers have asked study participants to avoid caffeine for 24 hours pre-study.

Use of prescription/ over-the-counter medications, herbal concoctions, and various supplements can affect sleep study results. Consequently it is important for researchers to communicate how these were accounted for in their studies.
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C57105
Acclimation process description text
AccPrcssDscrptnTxt
Free text field related to the description of the acclimation process used
If yes, describe the acclimation process and/or pre-study instructions. (free text)
  
Alphanumeric
No instructions available
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
 
255
Free-Form Entry
       
C57106
Medication help sleep problem indicator
MdHlpSlpPrbInd
Indicator of whether medication was taken regularly to help with sleep problems
Did the subject take any prescription/over the counter medication, supplements, or herbal preparations regularly to help with their sleep problems?
Yes;No;
Yes;No;
Alphanumeric
No instructions available
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C57107
Medication taken neurologic psychiatric affect sleep indicator
MdTknNrPsyAffSlpInd
Indicator of if the subject has taken any neurologic or psychiatric medication that is known to affect sleep
Did the subject take any neurologic, psychiatric medications, or other medication commonly known to affect sleep?
Yes;No;
Yes;No;
Alphanumeric
List medicines vs. specify drug categories in the medication log.
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C57108
Medication neurologic psychiatric type text
MdNrlPsycTypTxt
Free text field of medication (neurologic or psychiatric) type that was taken that is known to affect sleep
If yes, what medications did the subject take? (List medicines vs. specify drug categories)
  
Alphanumeric
List of medicines if the subject has taken any neurologic, psychiatric medications or other mediation commonly known to affect sleep.
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
 
255
Free-Form Entry
       
C57109
Medication affect sleep stop indicator
MdAffctSlpStpInd
Indicator of whether medications known to affect sleep were stopped before the sleep study
Were all medications that could affect sleep stopped before the sleep study?
Yes;No;Other instructions given, please specify;No specific instructions given to subject;
Yes;No;Other instructions given, please specify;No specific instructions given to subject;
Alphanumeric
No instructions available
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C58439
Medication stopped other instructions given specify text
MedStopOthrInstrucGivSpecTxt
Other instructions given to subject indicating if medications that could affect sleep were stopped prior to sleep study
Other instructions given, please specify
  
Alphanumeric
Specify if the subject was given other instructions regarding stopping medication that could affect sleep before the sleep study
No references available
Adult;Pediatric
Supplemental–Highly Recommended
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
C58438
Prior to study medication stopped duration
PriorToStdyMedStopDur
Yes or other instructions given indicating the duration of time prior to the sleep study that that subject stopped medications that could affect sleep
If ‘yes’ or ‘other instructions given’, how long prior to the study were medications stopped?
  
Numeric Values
Yes or other instructions given indicating how long prior to the sleep study subject stopped the medications that could affect sleep
No references available
Adult;Pediatric
Supplemental–Highly Recommended
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
C57110
Sleep wake time correspond subject sleep wake time indicator
SlpWkTmeCrrsSbjctSlpWkTmInd
Indicator of whether sleep/wake times correspond to the subjects' usual sleep/wake times
Did sleep/wake times correspond to the subjects' usual sleep/wake times?
Yes;No;
Yes;No;
Alphanumeric
Note: In prior sleep studies, subjects slept or woke up based on researcher-determined times, which might be very different from what the subject’s usual sleep/wake schedules.

If sleep and wake times in a study are very different from a study participant's usual schedule, these factors can impact results
1. Jackson ML, Bruck D. Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review. Journal of Clinical Sleep Medicine?: JCSM?: Official Publication of the American Academy of Sleep Medicine. 2012;8(6):719-728. doi:10.5664/jcsm.2276.

2. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

3. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C57111
Objective measure heart rate variability indicator
ObjctvMeasrHrtRtVrbltyInd
Indicator of whether objective measures related to heart rate variability were employed
Were objective measures related to heart rate variability employed
Yes;No;
Yes;No;
Alphanumeric
Were objective measures related to heart rate variability employed? - In a number of studies, ME/CFS study participants demonstrate lower heart rate variability (HRV) nocturnally compared to controls. Low heart rate variability may be linked to fatigue and unrefreshing sleep. More research to confirm and extend prior work is needed. HRV measures used in prior studies include HRV (heart rate variability), LF power (low-frequency power(ms²)), HF power (high-frequency power(ms²)), LF/HF ratio, TP (Total power(ms²)), RMSSD (root of the mean squares of differences between adjacent R–R intervals), SDNN (standard deviation on R–R intervals), COVR (coefficient of variation), PNN50 (number of pairs of adjacent R–R intervals differing by 450 ms divided by the total number of R–R intervals). Researchers should try to include one if not more of these measures when investigating HRV. HRV can be confounded by many factors and these should be taken into account when designing studies. Some factors that have been identified are age, gender, medication use, presence of a psychiatric condition, physical activity, breathing rate/ frequency, heart disease, and acute stress situations. The equipment used should have been validated against a gold standard like ECG.
1. Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I, De Wandele I, Da Silva H, Calders P. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013 Oct;43(2):279-87. doi: 10.1016/j.semarthrit.2013.03.004. Epub 2013 Jul 6.

2. Tak LM, Riese H, de Bock GH, Manoharan A, Kok IC, Rosmalen JG. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol. 2009 Oct;82(2):101-10. doi: 10.1016/j.biopsycho.2009.05.002. Epub 2009 May 20.
a. This is an older article. It is being referenced because it contains a table designating elements that should be reported in studies of heart rate variability.
Adult;Pediatric
Supplemental
1.0
12/27/2017
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Single Pre-Defined Value Selected
       
C58440
Objective measure taken what measure text
ObjMeasrTkenWhatMeasrTxt
Text indicating what objective measures were taken
What was measured
  
Alphanumeric
In a number of studies, ME/CFS study participants demonstrate lower heart rate variability (HRV) nocturnally compared to controls. Low heart rate variability may be linked to fatigue and unrefreshing sleep. More research to confirm and extend prior work is needed. HRV measures used in prior studies include HRV (heart rate variability), LF power (low-frequency power(ms²)), HF power (high-frequency power(ms²)), LF/HF ratio, TP (Total power(ms²)), RMSSD (root of the mean squares of differences between adjacent R–R intervals), SDNN (standard deviation on R–R intervals), COVR (coefficient of variation), PNN50 (number of pairs of adjacent R–R intervals differing by 450 ms divided by the total number of R–R intervals). Researchers should try to include one if not more of these measures when investigating HRV. HRV can be confounded by many factors and these should be taken into account when designing studies. Some factors that have been identified are age, gender, medication use, presence of a psychiatric condition, physical activity, breathing rate/ frequency, heart disease, and acute stress situations. The equipment used should have been validated against a gold standard like ECG.
No references available
Adult;Pediatric
Supplemental
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
C58441
Objective measure method of measurement text
ObjctMeasrMethOfMeasurmntTxt
Text indicating objective measures method of measurement
Method of measurement
  
Alphanumeric
In a number of studies, ME/CFS study participants demonstrate lower heart rate variability (HRV) nocturnally compared to controls. Low heart rate variability may be linked to fatigue and unrefreshing sleep. More research to confirm and extend prior work is needed. HRV measures used in prior studies include HRV (heart rate variability), LF power (low-frequency power(ms²)), HF power (high-frequency power(ms²)), LF/HF ratio, TP (Total power(ms²)), RMSSD (root of the mean squares of differences between adjacent R–R intervals), SDNN (standard deviation on R–R intervals), COVR (coefficient of variation), PNN50 (number of pairs of adjacent R–R intervals differing by 450 ms divided by the total number of R–R intervals). Researchers should try to include one if not more of these measures when investigating HRV. HRV can be confounded by many factors and these should be taken into account when designing studies. Some factors that have been identified are age, gender, medication use, presence of a psychiatric condition, physical activity, breathing rate/ frequency, heart disease, and acute stress situations. The equipment used should have been validated against a gold standard like ECG.
No references available
Adult;Pediatric
Supplemental
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
C58442
Objective measure when performed text
ObjctMeasrWhenPerfromTxt
Text indicating when the objective measures were performed
When measures were performed
  
Alphanumeric
In a number of studies, ME/CFS study participants demonstrate lower heart rate variability (HRV) nocturnally compared to controls. Low heart rate variability may be linked to fatigue and unrefreshing sleep. More research to confirm and extend prior work is needed. HRV measures used in prior studies include HRV (heart rate variability), LF power (low-frequency power(ms²)), HF power (high-frequency power(ms²)), LF/HF ratio, TP (Total power(ms²)), RMSSD (root of the mean squares of differences between adjacent R–R intervals), SDNN (standard deviation on R–R intervals), COVR (coefficient of variation), PNN50 (number of pairs of adjacent R–R intervals differing by 450 ms divided by the total number of R–R intervals). Researchers should try to include one if not more of these measures when investigating HRV. HRV can be confounded by many factors and these should be taken into account when designing studies. Some factors that have been identified are age, gender, medication use, presence of a psychiatric condition, physical activity, breathing rate/ frequency, heart disease, and acute stress situations. The equipment used should have been validated against a gold standard like ECG.
No references available
Adult;Pediatric
Supplemental
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
C58443
Objective measure describe equipment used text
ObjctMeasrDesEquipUseTxt
Text describing what objective measures equipment used
Describe equipment used
  
Alphanumeric
In a number of studies, ME/CFS study participants demonstrate lower heart rate variability (HRV) nocturnally compared to controls. Low heart rate variability may be linked to fatigue and unrefreshing sleep. More research to confirm and extend prior work is needed. HRV measures used in prior studies include HRV (heart rate variability), LF power (low-frequency power(ms²)), HF power (high-frequency power(ms²)), LF/HF ratio, TP (Total power(ms²)), RMSSD (root of the mean squares of differences between adjacent R–R intervals), SDNN (standard deviation on R–R intervals), COVR (coefficient of variation), PNN50 (number of pairs of adjacent R–R intervals differing by 450 ms divided by the total number of R–R intervals). Researchers should try to include one if not more of these measures when investigating HRV. HRV can be confounded by many factors and these should be taken into account when designing studies. Some factors that have been identified are age, gender, medication use, presence of a psychiatric condition, physical activity, breathing rate/ frequency, heart disease, and acute stress situations. The equipment used should have been validated against a gold standard like ECG.
No references available
Adult;Pediatric
Supplemental
1.0
2/14/2018
Aliases for variable name not defined
Sleep Focused Study Questionnaire
Sleep
Outcomes and End Points
  
Free-Form Entry
       
12-14-2018
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