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CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease: Huntington's Disease
Sub-Domain: Cognitive
CRF: Written Verbal Fluency Test
Item count: 5 (5 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C12025
Written Verbal Fluency Test (WVFT) - write letter S word five minute count
WVFTWriteLtrSWord5MinCt
Count of legitimate words beginning with the letter S written by the participant/subject in 5 minutes
Scoring
  
Numeric Values
Write as many words as possible beginning with the letter S in 5 minutes.
Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26.
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Written Verbal Fluency Test
Cognitive
Outcomes and End Points
Abrahams Written Verbal Fluency Q1
 
Free-Form Entry
       
C12026
Written Verbal Fluency Test (WVFT) - write four letter C word four minute count
WVFTWrite4LtrCWord4MinCt
Count of legitimate words exactly 4 letters long and beginning with the letter C that the participant/subject was able to write in 4 minutes
Scoring
  
Numeric Values
Write as many words consisting of four letters only beginning with the letter C in four minutes.
Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grise D, Goldstein LH. Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia 38(2000):734-747. Abrahams, S., Goldstein, LH., Al-Chalabi, A., Pickering, A., Morris, RG., Passingham, RE., Brooks, DJ. and Leigh PN. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62, 464-472. Abrahams, S., Goldstein, L.H., Simmons, A., Brammer, M. J., Williams, S. C. R. Giampietro, V. and Leigh, P.N (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127, 1507 - 1517. Abrahams, S., Goldstein, L.H., Suckling, J., Ng, V., Simmons, A., Giampietro, V. Atkins, L., Williams, S.C.R. and Leigh, P.N.. (2005a) Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology. 252, 321-331. Abrahams, S., Goldstein, L.H. and Leigh, P.N. (2005b) Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64 1222-1226
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Written Verbal Fluency Test
Cognitive
Outcomes and End Points
Abrahams Written Verbal Fluency Q2
 
Free-Form Entry
       
C12027
Written Verbal Fluency Test (WVFT) - copy previous word rapid text
WVFTCopyPrevWordRapidTxt
Text of previously generated words copied by the participant/subject as fast as possible as part of Written Verbal Fluency Test
The participant/subject copies the words previously generated as fast as possible
  
Alphanumeric
No additional instructions
Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26.
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Written Verbal Fluency Test
Cognitive
Outcomes and End Points
Abrahams Written Verbal Fluency Q3
255
Free-Form Entry
       
C12028
Written Verbal Fluency Test (WVFT) - copy word fast possible duration
WVFTCopyWordFastPossDur
Duration required by the participant/subject to copy the legitimate words from both the intial-S list and the 4-letter initial-C list as fast as possible
Scoring
  
Numeric Values
Following a delay (which reduces fatigue), the patient is timed as they copy the words they previously generated as fast as possible.
Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26.
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Written Verbal Fluency Test
Cognitive
Outcomes and End Points
Abrahams Written Verbal Fluency Q4
 
Free-Form Entry
       
C12029
Written Verbal Fluency Test (WVFT) - index value
WVFTIndexVal
Value of the Written Verbal Fluency Index, calculated by subtracting the time taken to copy the words from 9 minutes, then dividing the resulting time by the number of legitimate words
Scoring
  
Numeric Values
The patient is timed as they copy the words they previously generated as fast as possible, from which a Written Verbal Fluency Index is calculated. This consists of an estimate of the average time to 'think' of each word [(the time allowed for the test: 9 minutes minus the time taken to copy the words], divided by the total number of correct words].
Abrahams S., Leigh P.N., Harvey A., Vythelingum G.N., Grise D., Goldstein L.H. (2000). Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia, 38:734-47. Abrahams S., Goldstein L.H., Al-Chalabi A., Pickering A., Morris R.G., Passingham R.E., Brooks D.J. and Leigh P.N. (1997). Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 62:464-72. Abrahams S., Goldstein L.H., Simmons A., Brammer M.J., Williams S.C.R., Giampietro V. and Leigh P.N. (2004). Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain, 127:1507-17. Abrahams S., Goldstein L.H., Suckling J., Ng V., Simmons A., Giampietro V., Atkins L., Williams S.C.R. and Leigh, P.N. (2005a). Fronto-temporal white matter changes in patients with amyotrophic lateral sclerosis. Journal of Neurology, 252:321-31. Abrahams S., Goldstein L.H. and Leigh P.N. (2005b). Cognitive change in amyotrophic lateral sclerosis: a prospective study. Neurology, 64:1222-26.
Adult
Supplemental
3.0
7/22/2013
Aliases for variable name not defined
Written Verbal Fluency Test
Cognitive
Outcomes and End Points
Abrahams Written Verbal Fluency Q5
 
Free-Form Entry
       
03-22-2017
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