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CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease: Epilepsy
Sub-Domain: Classification
CRF: Classification of Etiology
Item count: 11 (11 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C14422
Epilepsy etiology general classification type
EpilepsyEtioGenClassTyp
The categorization for general etiology of epilepsy as linked to either identifed structural or metabolic causes or presumed genetic or unknown causes. Genetic (or presumed) causes of epilepsy are understood to be the direct result of a known or presumed genetic defect(s) in which seizures are the core symptom of the disorder. Unknown cause is meant to be taken neutrally and to designate that the nature of the underlying cause is not yet unknown. Structural or metabolic causes are due to a distinct condition that has been associated with substantially increased risk of developing epilepsy as demonstrated in appropriately designed studies.
Etiology Classification
Genetic or presumed genetic OR epilepsy of unknown cause;Structural or metabolic;
Genetic or presumed genetic OR epilepsy of unknown cause;Structural or metabolic;
Alphanumeric
Choose one. Only one of "Genetic or presumed genetic OR epilepsy of unknown cause" and "Structural or metabolic" should be recorded as present.
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology classification genetic or unknown likelihood type
 
Single Pre-Defined Value Selected
       
C14423
Epilepsy etiology general attribution confidence type
EpilepsyEtioGenAttrbConfidTyp
The level of confidence attributed to the categorizing of general etiology of epilepsy to either structural or metabolic causes versus genetic or unknown factors.
Present
No;Possible;Probable;Definite;Unknown;N/A;
No;Possible;Probable;Definite;Unknown;N/A;
Alphanumeric
Choose one. One attribution should be assigned for either "Genetic or presumed genetic OR epilepsy of unknown cause" or "Structural or metabolic", not both.
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology classification structural or metabolic likelihood type
 
Single Pre-Defined Value Selected
       
C18928
Epilepsy etiology specific classification other text
EpilepsyEtioSpecClassOTH
The free-text field related to 'Epilepsy etiology specific classification type' specifying other text. The specific etiologies preceeding the development of epilepsy in the participant/subject, as described by the International League Against Epilepsy (ILAE).
Other, specify
  
Alphanumeric
Specific etiologies are listed, However, where evidence is lacking that a specific etiology proceeds the development of epilepsy, it is not assumed that such pathology causes epilepsy. A response needs to be completed for each etiology - choose one.
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
 
4000
Free-Form Entry
       
C14424
Epilepsy etiology specific classification type
EpilepsyEtioSpecClassTyp
The specific etiologies preceeding the development of epilepsy in the participant/subject, as described by the International League Against Epilepsy (ILAE).
Specific Etiologies
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause as evidenced by the presence of mental retardation, cerebral palsy, or autism with no evidence of a specific insult or disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Alphanumeric
Specific etiologies are listed, However, where evidence is lacking that a specific etiology proceeds the development of epilepsy, it is not assumed that such pathology causes epilepsy. A response needs to be completed for each etiology - choose one.
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Core
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology specific type
 
Single Pre-Defined Value Selected
       
C18501
Epilepsy etiology specific genetic presumed text
EpilEtioSpecGenPresTxt
The free text field to describe the genetic or presumed genetic etiology for epilepsy in the participant/subject.
Genetic or presumed genetic, if known specify
  
Alphanumeric
No instructions available
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. Epub 2010 Feb 26. Freely available online at: http://www.ilae.org/Visitors/Centre/ctf/ctfoverview.cfm http://www.ilae-epilepsy.org/Visitors/Documents/ClassificationSummaryReportwebAug2009.pdf.
Adult;Pediatric
Supplemental–Highly Recommended
3.0
7/30/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
 
255
Free-Form Entry
       
C14425
Epilepsy etiology specific attribution confidence type
EpilepsyEtioSpecAttrbConfidTyp
The level of confidence that a specific etiology contributed to the development of epilepsy in the participant/subject.
Present
No;Possible;Probable;Definite;Unknown;N/A;
No;Possible;Probable;Definite;Unknown;N/A;
Alphanumeric
Choose one for each specific etiology type
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology specific present likelihood type
 
Single Pre-Defined Value Selected
       
C14426
Epilepsy etiology primary type
EpilEtioPrimryTyp
Primary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Primary Cause
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause as evidenced by the presence of mental retardation, cerebral palsy, or autism with no evidence of a specific insult or disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a primary cause must be selected. Choose the letter corresponding to the etiology for the primary cause (e.g., c would be chosen if the primary cause was stroke).
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology primary type
 
Single Pre-Defined Value Selected
       
C18929
Epilepsy etiology primary other text
EpilepsyEtioPrimryOTH
The free-text field related to 'Epilepsy etiology primary type' specifying other text. Primary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Other, specify
  
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a primary cause must be selected. Choose the letter corresponding to the etiology for the primary cause (e.g., c would be chosen if the primary cause was stroke).
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
 
4000
Free-Form Entry
       
C14427
Epilepsy etiology secondary type
EpilEtioSecondaryTyp
Secondary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Secondary Cause
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Viral, bacterial and parasitic infections;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Genetic and chromosomal development encephalopathies;Developmental encephalopathy of unknown cause as evidenced by the presence of mental retardation, cerebral palsy, or autism with no evidence of a specific insult or disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Genetic or presumed genetic;Epilepsy of unknown cause, without relevant abnormalities on examination, cognition, history, or imaging;Other, specify;
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a secondary cause must be selected. Choose the letter corresponding to the etiology for the secondary cause (e.g., b would be chosen if the secondary cause was traumatic brain injury).
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology secondary type
 
Single Pre-Defined Value Selected
       
C18930
Epilepsy etiology secondary other text
EpilepsyEtioSecondaryOTH
The free-text field related to 'Epilepsy etiology secondary type' specifying other text. Secondary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Other, specify
  
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a secondary cause must be selected. Choose the letter corresponding to the etiology for the secondary cause (e.g., b would be chosen if the secondary cause was traumatic brain injury).
EPILEPSY: Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
 
4000
Free-Form Entry
       
C20332
Epilepsy etiology multiple etiologies specify text
EpilEtioMultEtioSpecTxt
The free text field to describe the specific etiologies that are selected by the participant/subject.
If more than one specific etiology is selected, specify:
  
Alphanumeric
No instructions available
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Mosh顓L, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. Epub 2010 Feb 26. Freely available online at: http://www.ilae.org/Visitors/Centre/ctf/ctfoverview.cfm http://www.ilae-epilepsy.org/Visitors/Documents/ClassificationSummaryReportwebAug2009.pdf.
Adult;Pediatric
Supplemental–Highly Recommended
1.0
3/4/2015
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
 
255
Free-Form Entry
       
09-25-2017
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