of0
Export
 
CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease: Epilepsy
Sub-Domain: Classification
CRF: Classification of Etiology
Item count: 8 (8 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C58580
Specific epilepsy etiology classification type
SpecEpilepsyEtioClassTyp
The categorization for etiology of epilepsy as linked to identified genetic or presumed genetic, structural, metabolic, immune, infectious or unknown causes. Genetic (or presumed) causes of epilepsy are understood to be the direct result of a known or presumed genetic defect(s) in which seizures are the core symptom of the disorder. Unknown cause is meant to be taken neutrally and to designate that the nature of the underlying cause is not yet unknown. Structural, metabolic, immune or infectious causes are due to a distinct condition that has been associated with substantially increased risk of developing epilepsy as demonstrated in appropriately designed studies.
Specific Etiology
Genetic or presumed genetic;Structural;Metabolic/toxic;Other;
Genetic or presumed genetic;Structural;Metabolic/toxic;Other;
Alphanumeric
No instructions available.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x
Adult;Pediatric
Core
1.0
10/9/2018
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Null
Null
Single Pre-Defined Value Selected
Null
Null
Null
    
C14425
Epilepsy etiology specific attribution confidence type
EpilepsyEtioSpecAttrbConfidTyp
The level of confidence attributed to the categorizing of specific etiology of epilepsy to genetic or presumed genetic, structural, metabolic, immune, infectious or unknown factors.
Present?
No;Possible;Probable;Definite;Unknown;N/A;
No;Possible;Probable;Definite;Unknown;N/A;
Alphanumeric
If more than one etiology is present, please identify each plausible etiology (e.g., patient had a traumatic brain injury with loss of consciousness, but also had a known CNS abscess
If one etiology could be considered as fitting in two different categories, please check boxes for BOTH categories. Examples include 1) Tuberous Sclerosis Complex, which is both structural and genetic and 2) Glut-1 deficiency which is both metabolic and genetic

No = Not present; Possible = The summary of evidence suggests less than 50% confidence level; Probable = the summary of evidence sugests greater than 50% confidence level; Definite = The summary of evidence suggests 100% confidence level; Unknown = The summary of evidence is not suffiecient to support a finding; N/A = Not Applicable; to be used at the discretion fo the Principal Investigator based on study design.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
3.0
8/28/2013
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology specific present likelihood type
 
Single Pre-Defined Value Selected
       
C14426
Epilepsy etiology primary type
EpilEtioPrimryTyp
Primary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Primary Cause
Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other;
Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other (e.g., encephalocele, structural abnormality of unknown cause);
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a primary cause must be selected. Choose the letter corresponding to the etiology for the primary cause (e.g., c would be chosen if the primary cause was stroke).
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology primary type
 
Single Pre-Defined Value Selected
       
C14427
Epilepsy etiology secondary type
EpilEtioSecondaryTyp
Secondary etiologic cause for epilepsy when multiple etiologies are present (i.e., more than one etiology, as described by the International League Against Epilepsy, is coded as definite or possible).
Secondary Cause
Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other;
Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified;Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Mesial Temporal Sclerosis;Dementia;Other degenerative neurologic diseases;Structural, other (e.g., encephalocele, structural abnormality of unknown cause);
Alphanumeric
If more than one specific etiology is selected, specify:
If more than one etiology has been coded as definite or possible, then a secondary cause must be selected. Choose the letter corresponding to the etiology for the secondary cause (e.g., b would be chosen if the secondary cause was traumatic brain injury).
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ilae-epilepsy.org/Visitors/Centre/ctf/ctfoverview.cfm
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/5/2012
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Epilepsy etiology secondary type
 
Single Pre-Defined Value Selected
       
C58582
Genetic presumed genetic epilepsy etiology type
GeneticPresumeGenEpilEtioTyp
The categorization for genetic or presumed genetic etiology of epilepsy
Genetic or presumed genetic
Idiopathic generalized with known syndrome;Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome;Known genetic mutation with or without developmental /epileptic encephalopathy or known disease/syndrome linked to genetic mutation;Focal epilepsy with or without a known proven mutation;Genetic epilepsies not otherwise specified;
Idiopathic generalized with known syndrome (childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy, generalized GTCS alone);Other generalized epilepsy known or presumed to be genetic but not meeting criteria for an idiopathic generalized epilepsy syndrome (e.g., Doose Syndrome);Known genetic mutation with or without developmental /epileptic encephalopathy (e.g., CDKL5) or known disease/syndrome linked to genetic mutation (e.g., Dravet syndrome);Focal epilepsy with or without a known proven mutation (e.g., LGI1, ADNFL);Genetic epilepsies not otherwise specified;
Alphanumeric
If genetic or presumed genetic etiology, specify type. Etiologies that are both genetic and structural will be captured under genetic, not otherwise specified
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/10/2018
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Null
Null
Single Pre-Defined Value Selected
Null
Null
Null
    
C58587
Structural epilepsy etiology type
StructuralEpilEtioTyp
The categorization for structural etiology of epilepsy
Structural
Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes;Inborn errors of metabolism;Developmental/epileptic encephalopathy of unknown cause;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Dementia;Other degenerative neurologic diseases;Mesial Temporal Sclerosis;Structural, other;
Traumatic brain injury;Stroke;Intraventricular hemorrhage;Hypoxic-ischemic encephalopathy;Other metabolic or toxic insults;Neurocutaneous syndromes (e.g., tuberous sclerosis, neurofibromatosis);Inborn errors of metabolism;Developmental/epileptic encephalopathy of unknown cause as evidenced by the presence of intellectual disability, cerebral palsy, or autism with no evidence of a specific insult of disorder to which cause can be attributed preceding the onset of epilepsy;Malformations of cortical or other brain development with or without known genetic determinants;Neoplasia;Dementia;Other degenerative neurologic diseases;Mesial Temporal Sclerosis;Structural, other (e.g., encephalocele, structural abnormality of unknown cause);
Alphanumeric
If structural etiology, select the specific type. Etiologies that are both genetic and structural will be captured under genetic, not otherwise specified
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/10/2018
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Null
Null
Single Pre-Defined Value Selected
Null
Null
Null
    
C58605
Metabolic toxic epilepsy etiology type
MetabolToxicEpilEtioTyp
The categorization for metabolic toxic etiology of epilepsy
Metabolic/toxic
Inborn errors of metabolism;Other metabolic or toxic insults;
Inborn errors of metabolism;Other metabolic or toxic insults;
Alphanumeric
If metabolic toxic etiology, select the specific type.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/10/2018
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Null
Null
Single Pre-Defined Value Selected
Null
Null
Null
    
C58606
Other epilepsy etiology type
OtherEpilEtioTyp
The categorization for other etiology of epilepsy
Other
Immune;Infectious;Unknown;
Immune;Infectious(viral, bacterial, parasitic);Unknown (epilepsy of unknown cause, without relevant abnormalities on examination, coginition, history or imaging);
Alphanumeric
If other etiology, select the specific type.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02522.x
Adult;Pediatric
Supplemental–Highly Recommended
1.0
10/10/2018
Aliases for variable name not defined
Classification of Etiology
Classification
Disease/Injury Related Events
Null
Null
Single Pre-Defined Value Selected
Null
Null
Null
    
12-17-2018
Page 1 of 1