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CDE Detailed Report
This report contains detailed information about the selected CDEs.
Note: If at least one CDE was selected from a copyright- or trademark-protected instrument/scale then all of the CDEs from that instrument/scale are included in this report.
Disease:
Sub-Domain: Laboratory Tests and Biospecimens/Biomarkers
CRF: Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Item count: 28 (28 distinct CDEs)
CDE ID
CDE Name
Variable Name
Definition / Description
Question Text
Permissible Value
Description
Data Type
Instructions
References
Population
Classification (e.g., Core)
Version #
Version Date
Aliases for Variable Name
CRF Module / Guideline
© or TM
Sub-Domain
Domain
Previous Title
Size
Input Restrictions
Min Value
Max Value
Measurement Type
LOINC ID
SNOMED
caDSR ID
CDISC ID
C12226
Specimen source type
SpecmnSourcTyp
Type of specimen collection source
Is this a biopsy or autopsy specimen?
Biopsy;Autopsy;
Biopsy;Autopsy;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Specimen source type
 
Single Pre-Defined Value Selected
       
C12227
Postmortem interval for autopsy specimen value
PstmrtmIntrvlApSpecmnVal
Interval in hours of time elapsed between death and the autopsy at which the tissue specimen was collected
If this is an autopsy specimen, what is the approximate postmortem interval?
  
Numeric Values
Only answered if "Autopsy" is answered for "Is this a biopsy or autopsy specimen?"
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Postmortem interval for autopsy specimen value
 
Free-Form Entry
  
hour
    
C12247
Biopsy and Autopsy tissue collection method type
BpApTissCollMethdTyp
The type of method used for collection of the tissue specimen
Method of tissue collection
Punch biopsy;Blister biopsy;Open biopsy;
Punch biopsy;Blister biopsy;Open biopsy;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy and Autopsy tissue collection method type
 
Single Pre-Defined Value Selected
       
C12285
Tissue specimen collection anatomic site
TissSpecmnCollAntmicSite
Anatomic site from which the tissue specimen was collected
Site of tissue collection
10cm above lateral malleolus;Other, specify;
10cm above lateral malleolus;Other, specify;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy and Autopsy tissue collection site
 
Single Pre-Defined Value Selected
       
C18830
Tissue specimen collection anatomic site other text
TissSpecmnCollAntmicOTH
The free-text field related to 'Tissue specimen collection anatomic site' specifying other text. Anatomic site from which the tissue specimen was collected
Other, specify
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
 
4000
Free-Form Entry
       
C12230
Tissue specimen collection date and time
TissSpecmnCollctnDateTime
Date (and time if applicable and known) when the tissue specimen was collected
Date of tissue collection
  
Date or Date & Time
Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).
No references available
Adult;Pediatric
Core
3.0
7/25/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Tissue specimen collection date and time
 
Free-Form Entry
       
C12229
Tissue specimen size measurement
TissSpecmnSizeMeasr
Measurement of the size of the tissue specimen collected
Size of tissue collected
  
Numeric Values
Answer should be recorded as a dimension (AAxAAxAA) in centimeters (cm).
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Tissue specimen measurement
 
Free-Form Entry
  
centimeter
    
C12231
Laboratory name
LabName
Name of laboratory where assessment was performed
Name of Laboratory where pathology was performed
  
Alphanumeric
Record the laboratory name where pathology was performed
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Laboratory name
255
Free-Form Entry
       
C12232
Laboratory director name
LabDirectorName
Name of laboratory director where assessment was performed
Name of Laboratory Director
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Laboratory director name
255
Free-Form Entry
       
C12233
Preservation technique used type
PresrvtnTechnqUseTyp
Type of preservation technique used to preserve the specimen
Freezing or Fixation Used?
Frozen;Formalin-fixed;Parformaldehyde-fixed;Zamboni’s solution-fixed;
Frozen;Formalin-fixed;Parformaldehyde-fixed;Zamboni’s solution-fixed;
Alphanumeric
Choose only one
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Preservation technique used type
 
Single Pre-Defined Value Selected
       
C12234
Preservation technique used amount value
PresrvtnTechnqUseAmntVal
Value of the amount of preservation solution or material used to preserve the specimen
Amount
  
Alphanumeric
Answer for the freezing or fixation technique used. Answer should be recorded in milligrams (mg). If amount used is not known, select Not known.
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Preservation technique used amount value
255
Free-Form Entry
  
milligram
    
C12235
Histochemical stains used type
HistchmclStainUseTyp
Type of standard histochemical stains used on the tissue specimen
Which standard histochemical stains were used?
H and E;anti-PGP 9.5;Other, specify;
H and E;anti-PGP 9.5;Other, specify;
Alphanumeric
Choose all that apply
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Histochemical stains used type
 
Multiple Pre-Defined Values Selected
       
C18828
Histochemical stains used other text
HistchmclStainUseOTH
The free-text field related to 'Histochemical stains used type' specifying other text. Type of standard histochemical stains used on the tissue specimen
Other, specify
  
Alphanumeric
Choose all that apply
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
 
4000
Free-Form Entry
       
C12286
Tissue specimen section thickness measurement
TissSpecmnSectnThickMeasr
Measurement in microns of the thickness of the section taken from the tissue specimen
Section Thickness
Unknown;
Unknown;
Alphanumeric
If thickness is not known, select Not known.
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy section thickness
 
Single Pre-Defined Value Selected
  
micron
    
C12287
Tissue specimen section count
TissSpecmnSectnCt
Count of the number of sections from the tissue specimen that were taken and evaluated
Number of sections quantified
Unknown;
Unknown;
Alphanumeric
If number of sections is not known, then select Not known.
No references available
Adult;Pediatric
Core
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy sections quantified number
 
Single Pre-Defined Value Selected
       
C12288
Tissue specimen section microscopy type
TissSpecmnSectnMicroscpyType
Type of microscopy used to view the sections taken from the tissue specimen
Microscopy technique
Brightfield;Fluorescence;
Brightfield;Fluorescence;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy microscopy technique type
 
Single Pre-Defined Value Selected
       
C12289
Tissue specimen section quantify type
TissSpecmnSectnQuantfyTyp
Type of quantification used in evaluating the sections taken from the tissue specimen
Quantification method used
Manual counting;Stereology;Computer-assisted;Other, specify;
Manual counting;Stereology;Computer-assisted;Other, specify;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy quantification method type
 
Single Pre-Defined Value Selected
       
C18831
Tissue specimen section quantify other text
TissSpecmnSectnQuantfyOTH
The free-text field related to 'Tissue specimen section quantify type' specifying other text. Type of quantification used in evaluating the sections taken from the tissue specimen
Other, specify
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
 
4000
Free-Form Entry
       
C18832
Tissue specimen section quantify volume normalize other text
TissSpecmnSectnQuantVolNormOTH
The free-text field related to 'Tissue specimen section quantify volume normalize type' specifying other text. Type of method used to normalize the volume of the tissue specimen
Other, specify
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
 
4000
Free-Form Entry
       
C12290
Tissue specimen section quantify volume normalize type
TissSpecmnSectnQuantVolNormTyp
Type of method used to normalize the volume of the tissue specimen
Method for normalizing specimen volume
Section length;Using grid;Other, specify;Not known;
Section length;Using grid;Other, specify;Not known;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy normalizing specimen value method
 
Single Pre-Defined Value Selected
       
C12291
Tissue specimen counting threshold type
TissSpcmnSctnQuantCtThrshldTyp
Type of threshold for counting in the tissue specimen
Threshold for counting
All immunoreactive profiles;Only nerves crossing the dermal/epidermal border;
All immunoreactive profiles (including nerve fragments);Only nerves crossing the dermal/epidermal border;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy counting threshold type
 
Single Pre-Defined Value Selected
       
C12292
Tissue specimen Langerhans cell process result type
TissSpcmnLngrhnsCelProcRsltTyp
Result for the number of Burden of Langerhans cell processes in the tissue specimen
Burden of Langerhans cell processes
Low;Moderate;High;Not known;
Low;Moderate;High;Not known;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/25/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy langerhans cell process rating result
 
Single Pre-Defined Value Selected
       
C12293
Tissue specimen intraepidermal nerve fiber density value
TisIntraepdrmlNrvFibrDnsityVal
Value of the intraepidermal nerve fiber density in the tissue specimen
Intraepidermal nerve fiber density
  
Numeric Values
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy intraepidermal nerve fiber density value
 
Free-Form Entry
       
C12294
Laboratory pathology normal range
LabPatholNrmlRng
Range of intraepidermal nerve fiber density that is considered normal at the pathology laboratory examining the tissue specimen
Normal range for this laboratory
  
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy lab normal range
255
Free-Form Entry
       
C12295
Laboratory pathology normal range age match indicator
LabPatholNrmlRngAgeMatchInd
Indicator of whether the pathology laboratory's normal range of intraepidermal nerve fiber density is age-matched to the patient from whom the tissue specimen was taken
Is the normal range approximately age-matched to the patient
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy lab normal range age matched indicator
 
Single Pre-Defined Value Selected
       
C12296
Tissue specimen sweat gland innervation evaluate indicator
TissSpcmnSwtGlndInnrvtnEvalInd
Indicator of whether sweat gland innervation was evaluated for the tissue specimen
Was sweat gland innervation evaluated?
Yes;No;Unknown;
Yes;No;Unknown;
Alphanumeric
No instructions available
No references available
Adult;Pediatric
Supplemental
3.0
7/24/2013
Aliases for variable name not defined
Skin Biopsies for Qualification of Intraepidermal Nerve Fibers
Laboratory Tests and Biospecimens/Biomarkers
Assessments and Examinations
Biopsy sweat gland innervation evaluated indicator
 
Single Pre-Defined Value Selected
       
12-17-2018
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